ENSG00000128656

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000409597 ENSG00000128656 HEK293_OSMI2_2hA HEK293_TMG_2hB CHN1 protein_coding protein_coding 13.39305 11.08206 15.78518 0.1095836 0.5248106 0.5099578 2.4462326 4.4688993 0.5632830 0.4275847 0.5632830 -2.9658248 0.19601250 0.40276667 0.03526667 -0.36750000 0.02580512 0.0142037 FALSE TRUE
ENST00000443238 ENSG00000128656 HEK293_OSMI2_2hA HEK293_TMG_2hB CHN1 protein_coding protein_coding 13.39305 11.08206 15.78518 0.1095836 0.5248106 0.5099578 0.7900801 0.4248814 0.9270406 0.4248814 0.9270406 1.1074896 0.05020417 0.03903333 0.06263333 0.02360000 0.99048492 0.0142037 FALSE TRUE
ENST00000488080 ENSG00000128656 HEK293_OSMI2_2hA HEK293_TMG_2hB CHN1 protein_coding processed_transcript 13.39305 11.08206 15.78518 0.1095836 0.5248106 0.5099578 0.7981297 0.1621184 1.7467985 0.1621184 0.2741093 3.3514756 0.06296667 0.01463333 0.10973333 0.09510000 0.06515370 0.0142037 FALSE TRUE
ENST00000650770 ENSG00000128656 HEK293_OSMI2_2hA HEK293_TMG_2hB CHN1 protein_coding nonsense_mediated_decay 13.39305 11.08206 15.78518 0.1095836 0.5248106 0.5099578 0.6088189 0.2949605 1.4116944 0.2949605 0.2026699 2.2209169 0.04840833 0.02660000 0.08953333 0.06293333 0.18137613 0.0142037 FALSE FALSE
ENST00000651063 ENSG00000128656 HEK293_OSMI2_2hA HEK293_TMG_2hB CHN1 protein_coding processed_transcript 13.39305 11.08206 15.78518 0.1095836 0.5248106 0.5099578 1.8258048 0.4273001 1.7383609 0.4273001 0.8736838 1.9993075 0.12401667 0.03923333 0.10673333 0.06750000 0.55569418 0.0142037 FALSE FALSE
ENST00000651246 ENSG00000128656 HEK293_OSMI2_2hA HEK293_TMG_2hB CHN1 protein_coding protein_coding 13.39305 11.08206 15.78518 0.1095836 0.5248106 0.5099578 2.1751040 1.7610241 2.9619890 0.3681008 0.2733970 0.7468449 0.15286250 0.15826667 0.18696667 0.02870000 0.75668096 0.0142037 FALSE TRUE
MSTRG.19533.17 ENSG00000128656 HEK293_OSMI2_2hA HEK293_TMG_2hB CHN1 protein_coding   13.39305 11.08206 15.78518 0.1095836 0.5248106 0.5099578 0.5050265 0.0000000 1.1998078 0.0000000 0.7235590 6.9186340 0.03032083 0.00000000 0.07926667 0.07926667 0.24379452 0.0142037 FALSE TRUE
MSTRG.19533.2 ENSG00000128656 HEK293_OSMI2_2hA HEK293_TMG_2hB CHN1 protein_coding   13.39305 11.08206 15.78518 0.1095836 0.5248106 0.5099578 1.3885008 1.2351500 1.7793273 0.2540560 0.9734769 0.5230977 0.11565000 0.11163333 0.10883333 -0.00280000 0.88582146 0.0142037 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000128656 E001 0.4762024 0.2154679622 7.341082e-01 8.251489e-01 2 174798809 174799312 504 - 0.203 0.132 -0.743
ENSG00000128656 E002 0.1817044 0.0397516299 4.066965e-01   2 174799313 174799338 26 - 0.000 0.132 12.297
ENSG00000128656 E003 0.5514428 0.0198832875 5.863041e-02 1.242837e-01 2 174799339 174799394 56 - 0.000 0.315 13.882
ENSG00000128656 E004 5.0886716 0.0031641768 1.119665e-01 2.084382e-01 2 174799395 174799491 97 - 0.661 0.869 0.838
ENSG00000128656 E005 5.3573488 0.0060410850 8.582027e-01 9.125108e-01 2 174799492 174799494 3 - 0.783 0.802 0.074
ENSG00000128656 E006 6.6921764 0.0037850020 3.742029e-01 5.186268e-01 2 174799495 174799499 5 - 0.824 0.928 0.397
ENSG00000128656 E007 8.0583389 0.0048812119 1.432668e-01 2.524740e-01 2 174799500 174799511 12 - 0.861 1.025 0.616
ENSG00000128656 E008 7.7595744 0.0043198533 7.771422e-02 1.557944e-01 2 174799512 174799514 3 - 0.824 1.025 0.760
ENSG00000128656 E009 8.5816664 0.0496302693 4.609001e-02 1.021994e-01 2 174799515 174799523 9 - 0.805 1.096 1.092
ENSG00000128656 E010 32.7945085 0.0006647371 5.255672e-05 2.945250e-04 2 174799524 174799604 81 - 1.390 1.633 0.831
ENSG00000128656 E011 81.2363357 0.0004477121 2.211294e-08 2.557915e-07 2 174799605 174799772 168 - 1.797 2.012 0.723
ENSG00000128656 E012 80.3390133 0.0017254732 3.965056e-08 4.364210e-07 2 174799773 174799896 124 - 1.783 2.016 0.783
ENSG00000128656 E013 57.4272251 0.0005330571 1.783057e-05 1.118526e-04 2 174799897 174799937 41 - 1.663 1.857 0.657
ENSG00000128656 E014 48.9587556 0.0005301123 2.150529e-08 2.492117e-07 2 174799938 174799966 29 - 1.544 1.822 0.942
ENSG00000128656 E015 42.9939357 0.0005416779 1.534406e-09 2.198023e-08 2 174799967 174799988 22 - 1.458 1.780 1.096
ENSG00000128656 E016 92.3553538 0.0007539704 2.328287e-06 1.785561e-05 2 174799989 174800170 182 - 1.876 2.050 0.582
ENSG00000128656 E017 78.6665216 0.0003624428 8.532091e-02 1.679250e-01 2 174800171 174800259 89 - 1.871 1.934 0.210
ENSG00000128656 E018 52.7085761 0.0004356296 9.812602e-01 9.923165e-01 2 174800260 174800283 24 - 1.735 1.732 -0.013
ENSG00000128656 E019 40.6020740 0.0005453736 1.258897e-01 2.284165e-01 2 174800284 174800287 4 - 1.663 1.575 -0.300
ENSG00000128656 E020 87.5508309 0.0003354106 4.329305e-01 5.753788e-01 2 174801707 174801812 106 - 1.939 1.963 0.082
ENSG00000128656 E021 1.3995762 0.0096765512 4.689645e-01 6.082949e-01 2 174801813 174802057 245 - 0.445 0.315 -0.748
ENSG00000128656 E022 0.4396707 0.0286559904 1.191388e-01 2.187085e-01 2 174805525 174805653 129 - 0.277 0.000 -13.651
ENSG00000128656 E023 84.5434147 0.0003786991 8.895408e-01 9.333801e-01 2 174808905 174809042 138 - 1.940 1.930 -0.034
ENSG00000128656 E024 0.4482035 0.0280187398 1.190620e-01 2.186071e-01 2 174810900 174811510 611 - 0.278 0.000 -13.652
ENSG00000128656 E025 47.4852892 0.0025399438 5.871419e-01 7.104861e-01 2 174811511 174811532 22 - 1.703 1.667 -0.122
ENSG00000128656 E026 52.6270525 0.0032672109 9.564673e-01 9.767269e-01 2 174811533 174811588 56 - 1.730 1.726 -0.014
ENSG00000128656 E027 0.4031496 0.0250507938 1.524858e-01 2.650614e-01 2 174812098 174812308 211 - 0.000 0.233 13.300
ENSG00000128656 E028 64.8894278 0.0111362446 4.935367e-01 6.305488e-01 2 174812309 174812370 62 - 1.843 1.790 -0.177
ENSG00000128656 E029 70.1879357 0.0081218846 4.883285e-01 6.259082e-01 2 174812371 174812456 86 - 1.875 1.826 -0.167
ENSG00000128656 E030 33.7544044 0.0096422962 4.367523e-01 5.787854e-01 2 174812457 174812458 2 - 1.573 1.508 -0.223
ENSG00000128656 E031 40.4032441 0.0010879261 2.051236e-01 3.325664e-01 2 174812459 174812482 24 - 1.655 1.579 -0.257
ENSG00000128656 E032 3.5146812 0.0047315620 6.716872e-01 7.778682e-01 2 174821729 174821779 51 - 0.631 0.691 0.251
ENSG00000128656 E033 58.2632721 0.0004002238 7.278080e-02 1.479775e-01 2 174824434 174824490 57 - 1.816 1.729 -0.293
ENSG00000128656 E034 37.3305323 0.0005398492 2.057457e-01 3.333497e-01 2 174824491 174824491 1 - 1.622 1.545 -0.261
ENSG00000128656 E035 36.9189768 0.0005423459 1.570421e-01 2.711651e-01 2 174824492 174824492 1 - 1.622 1.536 -0.291
ENSG00000128656 E036 36.9189768 0.0005423459 1.570421e-01 2.711651e-01 2 174824493 174824493 1 - 1.622 1.536 -0.291
ENSG00000128656 E037 37.2489743 0.0005417766 2.056096e-01 3.331918e-01 2 174824494 174824494 1 - 1.622 1.545 -0.261
ENSG00000128656 E038 46.6091734 0.0004921118 6.341296e-03 1.951177e-02 2 174824495 174824515 21 - 1.747 1.603 -0.490
ENSG00000128656 E039 36.5060093 0.0005574057 5.278042e-04 2.263621e-03 2 174824516 174824518 3 - 1.669 1.463 -0.702
ENSG00000128656 E040 0.0000000       2 174837113 174837336 224 -      
ENSG00000128656 E041 0.0000000       2 174846309 174846314 6 -      
ENSG00000128656 E042 0.0000000       2 174846315 174846418 104 -      
ENSG00000128656 E043 39.8639507 0.0005130546 2.094683e-03 7.517454e-03 2 174846880 174846913 34 - 1.693 1.518 -0.596
ENSG00000128656 E044 46.7470577 0.0005977136 4.141351e-03 1.353891e-02 2 174846914 174846957 44 - 1.754 1.603 -0.514
ENSG00000128656 E045 2.9883152 0.0124839180 2.749753e-01 4.142176e-01 2 174846958 174847312 355 - 0.490 0.659 0.772
ENSG00000128656 E046 2.5613325 0.2231059017 8.013043e-01 8.733961e-01 2 174847313 174847596 284 - 0.532 0.551 0.093
ENSG00000128656 E047 0.1515154 0.0424865645 5.831869e-01   2 174847719 174847801 83 - 0.113 0.000 -12.067
ENSG00000128656 E048 0.2903454 0.2797962432 3.338863e-01   2 174872020 174872114 95 - 0.203 0.000 -13.062
ENSG00000128656 E049 3.8761049 0.0040558327 1.791845e-01 3.001199e-01 2 174875788 174875865 78 - 0.783 0.584 -0.836
ENSG00000128656 E050 106.9497141 0.0032118604 4.322531e-03 1.404856e-02 2 174877840 174878128 289 - 2.094 1.965 -0.431
ENSG00000128656 E051 0.0000000       2 174878129 174878184 56 -      
ENSG00000128656 E052 0.0000000       2 174888567 174888723 157 -      
ENSG00000128656 E053 0.0000000       2 174893005 174893104 100 -      
ENSG00000128656 E054 0.0000000       2 174893182 174893731 550 -      
ENSG00000128656 E055 0.0000000       2 174909351 174909446 96 -      
ENSG00000128656 E056 51.0964384 0.0031052702 1.037564e-02 2.968654e-02 2 174915058 174915171 114 - 1.785 1.636 -0.502
ENSG00000128656 E057 0.0000000       2 174915172 174915253 82 -      
ENSG00000128656 E058 0.0000000       2 174915254 174915450 197 -      
ENSG00000128656 E059 0.0000000       2 174915451 174915572 122 -      
ENSG00000128656 E060 0.4407149 0.0213316369 6.815864e-01 7.852282e-01 2 174917325 174917431 107 - 0.203 0.132 -0.749
ENSG00000128656 E061 31.6057880 0.0090287445 7.218446e-03 2.179199e-02 2 174918534 174918565 32 - 1.606 1.390 -0.740
ENSG00000128656 E062 0.0000000       2 174938643 174940356 1714 -      
ENSG00000128656 E063 6.2314063 0.0026598890 3.926556e-01 5.365858e-01 2 174940816 174940894 79 - 0.911 0.801 -0.426
ENSG00000128656 E064 31.0551659 0.0086222001 6.067967e-04 2.557927e-03 2 174944888 174944943 56 - 1.621 1.349 -0.935
ENSG00000128656 E065 1.0361675 0.0117609592 8.232426e-02 1.631799e-01 2 174945170 174945261 92 - 0.445 0.132 -2.334
ENSG00000128656 E066 0.5244761 0.2387895122 7.497284e-01 8.365982e-01 2 174951743 174951837 95 - 0.204 0.134 -0.729
ENSG00000128656 E067 22.8381937 0.0266154838 9.621919e-03 2.783435e-02 2 174952164 174952202 39 - 1.496 1.206 -1.011
ENSG00000128656 E068 0.1451727 0.0427133186 5.841032e-01   2 174975862 174975931 70 - 0.113 0.000 -12.066
ENSG00000128656 E069 0.0000000       2 174997552 174997713 162 -      
ENSG00000128656 E070 0.2214452 0.0397039465 4.057054e-01   2 175004555 175004893 339 - 0.000 0.132 12.301
ENSG00000128656 E071 26.2812810 0.0008877591 4.029023e-06 2.928171e-05 2 175004894 175005080 187 - 1.573 1.248 -1.124
ENSG00000128656 E072 5.3798773 0.0385826471 9.463724e-01 9.703486e-01 2 175005081 175005205 125 - 0.824 0.819 -0.019
ENSG00000128656 E073 8.1212213 0.0045883816 3.450325e-03 1.158262e-02 2 175005206 175005432 227 - 1.101 0.750 -1.332