ENSG00000128626

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000308018 ENSG00000128626 HEK293_OSMI2_2hA HEK293_TMG_2hB MRPS12 protein_coding protein_coding 179.5932 390.8231 73.40054 14.14004 1.478729 -2.412494 96.82139 209.77199 36.89978 5.351514 0.3649942 -2.506816 0.5281708 0.5372000 0.5031000 -0.0341 3.153076e-01 9.737508e-09 FALSE  
ENST00000402029 ENSG00000128626 HEK293_OSMI2_2hA HEK293_TMG_2hB MRPS12 protein_coding protein_coding 179.5932 390.8231 73.40054 14.14004 1.478729 -2.412494 47.82481 114.65189 15.81940 5.961299 0.4452503 -2.856707 0.2451708 0.2930667 0.2154667 -0.0776 3.222372e-08 9.737508e-09 FALSE  
ENST00000407800 ENSG00000128626 HEK293_OSMI2_2hA HEK293_TMG_2hB MRPS12 protein_coding protein_coding 179.5932 390.8231 73.40054 14.14004 1.478729 -2.412494 32.78649 63.76528 19.10246 3.043500 1.3460996 -1.738484 0.2088708 0.1630333 0.2598333 0.0968 1.148284e-06 9.737508e-09 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000128626 E001 79.55373 6.668762e-03 1.359285e-01 2.423875e-01 19 38930944 38930953 10 + 1.798 1.717 -0.275
ENSG00000128626 E002 867.86078 8.996033e-05 3.363271e-13 8.871647e-12 19 38930954 38930998 45 + 2.848 2.747 -0.335
ENSG00000128626 E003 996.41642 1.159287e-04 3.434575e-06 2.538506e-05 19 38930999 38931171 173 + 2.869 2.813 -0.185
ENSG00000128626 E004 166.20606 3.294347e-04 3.307157e-03 1.116851e-02 19 38931172 38931275 104 + 2.127 2.031 -0.321
ENSG00000128626 E005 1725.99688 2.705100e-04 1.437028e-01 2.530494e-01 19 38931276 38931343 68 + 3.028 3.065 0.120
ENSG00000128626 E006 41.21533 5.854665e-04 1.158979e-11 2.387097e-10 19 38931344 38931861 518 + 1.787 1.373 -1.413
ENSG00000128626 E007 5227.31469 3.297215e-04 4.404707e-11 8.248083e-10 19 38932333 38933168 836 + 3.490 3.550 0.198