ENSG00000128607

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000335420 ENSG00000128607 HEK293_OSMI2_2hA HEK293_TMG_2hB KLHDC10 protein_coding protein_coding 11.95698 9.388622 14.37914 0.9777811 0.9427085 0.6144597 2.6333990 3.0999956 2.7319542 0.7288497 0.3529314 -0.1817081 0.2303542 0.34276667 0.19276667 -0.150000000 0.4058319131 0.0002164996 FALSE TRUE
ENST00000468226 ENSG00000128607 HEK293_OSMI2_2hA HEK293_TMG_2hB KLHDC10 protein_coding protein_coding 11.95698 9.388622 14.37914 0.9777811 0.9427085 0.6144597 0.3077104 0.0000000 0.8534107 0.0000000 0.4331358 6.4319751 0.0199000 0.00000000 0.05566667 0.055666667 0.2208462516 0.0002164996 FALSE FALSE
ENST00000495724 ENSG00000128607 HEK293_OSMI2_2hA HEK293_TMG_2hB KLHDC10 protein_coding processed_transcript 11.95698 9.388622 14.37914 0.9777811 0.9427085 0.6144597 1.0544865 1.8467468 1.1761593 0.1137556 0.3051530 -0.6464793 0.0955250 0.20056667 0.07983333 -0.120733333 0.0096039501 0.0002164996   FALSE
MSTRG.30681.1 ENSG00000128607 HEK293_OSMI2_2hA HEK293_TMG_2hB KLHDC10 protein_coding   11.95698 9.388622 14.37914 0.9777811 0.9427085 0.6144597 6.8436488 3.6368338 8.6105574 0.5776484 0.2347897 1.2411367 0.5531458 0.38276667 0.60216667 0.219400000 0.0002164996 0.0002164996 FALSE TRUE
MSTRG.30681.4 ENSG00000128607 HEK293_OSMI2_2hA HEK293_TMG_2hB KLHDC10 protein_coding   11.95698 9.388622 14.37914 0.9777811 0.9427085 0.6144597 1.1177317 0.8050458 1.0070630 0.8050458 0.2398496 0.3194561 0.1010750 0.07383333 0.06950000 -0.004333333 0.4153310345 0.0002164996 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000128607 E001 4.3941088 0.0116944272 0.782883326 0.860589747 7 130070534 130070549 16 + 0.697 0.763 0.272
ENSG00000128607 E002 7.3479858 0.0023095620 0.513602061 0.648394557 7 130070550 130070551 2 + 0.939 0.892 -0.177
ENSG00000128607 E003 24.2785147 0.0262043245 0.425148770 0.568093492 7 130070552 130070713 162 + 1.422 1.364 -0.202
ENSG00000128607 E004 15.7957880 0.0011672444 0.984593806 0.994430663 7 130070714 130070771 58 + 1.207 1.240 0.118
ENSG00000128607 E005 30.6155182 0.0129063738 0.284539106 0.424791673 7 130070772 130070809 38 + 1.523 1.463 -0.205
ENSG00000128607 E006 0.2966881 0.0270355531 0.316010191   7 130094895 130094931 37 + 0.185 0.000 -10.692
ENSG00000128607 E007 17.5827536 0.0515406143 0.335992328 0.479807773 7 130096921 130097007 87 + 1.186 1.344 0.558
ENSG00000128607 E008 72.3223944 0.0042282095 0.223989445 0.355180532 7 130116445 130116577 133 + 1.878 1.844 -0.114
ENSG00000128607 E009 70.1169464 0.0033575884 0.321405085 0.464647212 7 130116578 130116666 89 + 1.860 1.843 -0.060
ENSG00000128607 E010 7.7081036 0.0021691077 0.001594753 0.005943641 7 130117519 130117666 148 + 0.719 1.114 1.500
ENSG00000128607 E011 99.2528309 0.0003081530 0.171489316 0.290140001 7 130120749 130120903 155 + 2.009 1.995 -0.048
ENSG00000128607 E012 105.4309144 0.0004680815 0.019960963 0.051402730 7 130122054 130122202 149 + 2.048 2.000 -0.161
ENSG00000128607 E013 85.3524664 0.0017273113 0.086782991 0.170254306 7 130124451 130124535 85 + 1.953 1.912 -0.138
ENSG00000128607 E014 65.3737746 0.0006171565 0.102552149 0.194396664 7 130125865 130125931 67 + 1.836 1.796 -0.134
ENSG00000128607 E015 52.7854062 0.0005119282 0.335208677 0.478985648 7 130127404 130127451 48 + 1.734 1.721 -0.046
ENSG00000128607 E016 93.5490262 0.0003632839 0.380354630 0.524646462 7 130129437 130129576 140 + 1.945 2.011 0.220
ENSG00000128607 E017 1359.0053669 0.0064733036 0.217038488 0.346815221 7 130130537 130135705 5169 + 3.110 3.157 0.154