ENSG00000128602

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000249373 ENSG00000128602 HEK293_OSMI2_2hA HEK293_TMG_2hB SMO protein_coding protein_coding 37.25153 53.48882 27.0699 2.615183 0.3976688 -0.9822846 16.437313 21.8203466 13.9381690 2.7578390 0.4110499 -0.6462593 0.44393750 0.40520000 0.51556667 0.1103667 0.177174777 0.004661611 FALSE TRUE
ENST00000462420 ENSG00000128602 HEK293_OSMI2_2hA HEK293_TMG_2hB SMO protein_coding nonsense_mediated_decay 37.25153 53.48882 27.0699 2.615183 0.3976688 -0.9822846 2.113997 0.1954123 3.2121144 0.1954123 0.5131259 3.9714129 0.06907500 0.00370000 0.11820000 0.1145000 0.004661611 0.004661611 TRUE FALSE
ENST00000475779 ENSG00000128602 HEK293_OSMI2_2hA HEK293_TMG_2hB SMO protein_coding nonsense_mediated_decay 37.25153 53.48882 27.0699 2.615183 0.3976688 -0.9822846 4.299056 10.7775379 1.0094023 2.2163171 0.4105566 -3.4035702 0.09929167 0.20313333 0.03736667 -0.1657667 0.006048413 0.004661611 FALSE TRUE
MSTRG.30665.1 ENSG00000128602 HEK293_OSMI2_2hA HEK293_TMG_2hB SMO protein_coding   37.25153 53.48882 27.0699 2.615183 0.3976688 -0.9822846 5.209157 5.5975918 3.6964821 0.7367266 0.4705482 -0.5973308 0.14513750 0.10426667 0.13666667 0.0324000 0.517343506 0.004661611 FALSE TRUE
MSTRG.30665.5 ENSG00000128602 HEK293_OSMI2_2hA HEK293_TMG_2hB SMO protein_coding   37.25153 53.48882 27.0699 2.615183 0.3976688 -0.9822846 6.177738 12.5210717 3.3363328 1.0267516 0.3843118 -1.9048570 0.15337917 0.23690000 0.12293333 -0.1139667 0.018509393 0.004661611 FALSE TRUE
MSTRG.30665.6 ENSG00000128602 HEK293_OSMI2_2hA HEK293_TMG_2hB SMO protein_coding   37.25153 53.48882 27.0699 2.615183 0.3976688 -0.9822846 2.070307 1.8621854 0.8807813 0.8270947 0.1899082 -1.0715801 0.06190000 0.03353333 0.03263333 -0.0009000 0.942704840 0.004661611 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000128602 E001 14.641292 0.0012678335 1.592319e-01 2.740880e-01 7 129188480 129188597 118 + 1.217 1.117 -0.356
ENSG00000128602 E002 16.383653 0.0014539196 2.538287e-02 6.266725e-02 7 129188598 129188632 35 + 1.304 1.140 -0.580
ENSG00000128602 E003 30.741847 0.0173088640 3.455038e-04 1.561972e-03 7 129188633 129188694 62 + 1.637 1.355 -0.971
ENSG00000128602 E004 25.869384 0.0324374001 1.053170e-03 4.143459e-03 7 129188695 129188720 26 + 1.584 1.264 -1.106
ENSG00000128602 E005 24.333053 0.0176889946 8.968419e-04 3.603173e-03 7 129188721 129188812 92 + 1.535 1.255 -0.969
ENSG00000128602 E006 98.550053 0.0099967340 1.391743e-02 3.803872e-02 7 129188813 129189245 433 + 2.028 1.918 -0.367
ENSG00000128602 E007 23.731273 0.0539844489 4.188392e-05 2.402878e-04 7 129189246 129189293 48 + 1.637 1.139 -1.730
ENSG00000128602 E008 119.947311 0.0073641212 7.713445e-04 3.154905e-03 7 129189294 129189482 189 + 2.134 1.993 -0.473
ENSG00000128602 E009 2.526765 0.0385857842 6.454394e-03 1.980476e-02 7 129191898 129192097 200 + 0.779 0.335 -2.110
ENSG00000128602 E010 263.139312 0.0032064729 1.585854e-02 4.241998e-02 7 129203384 129203589 206 + 2.413 2.364 -0.165
ENSG00000128602 E011 198.133013 0.0004909209 2.003137e-03 7.236067e-03 7 129205203 129205282 80 + 2.291 2.236 -0.184
ENSG00000128602 E012 269.571215 0.0001866951 2.506235e-03 8.782143e-03 7 129205283 129205412 130 + 2.414 2.375 -0.129
ENSG00000128602 E013 349.047865 0.0001594136 1.554638e-05 9.885923e-05 7 129205610 129205782 173 + 2.539 2.483 -0.187
ENSG00000128602 E014 347.479459 0.0001405272 1.685928e-11 3.382693e-10 7 129206150 129206284 135 + 2.569 2.466 -0.343
ENSG00000128602 E015 306.537882 0.0001775360 5.029933e-04 2.171172e-03 7 129206285 129206369 85 + 2.474 2.430 -0.147
ENSG00000128602 E016 361.158960 0.0013394642 1.133933e-02 3.197579e-02 7 129206464 129206587 124 + 2.538 2.507 -0.104
ENSG00000128602 E017 296.604928 0.0022810903 4.773251e-01 6.158929e-01 7 129208759 129208851 93 + 2.422 2.435 0.043
ENSG00000128602 E018 8.587046 0.0359359925 5.184145e-03 1.642947e-02 7 129208852 129209281 430 + 1.153 0.805 -1.296
ENSG00000128602 E019 354.975372 0.0002666229 1.453903e-01 2.553895e-01 7 129209289 129209397 109 + 2.506 2.507 0.004
ENSG00000128602 E020 427.283541 0.0005910365 2.889040e-01 4.295535e-01 7 129210363 129210507 145 + 2.582 2.592 0.034
ENSG00000128602 E021 264.470651 0.0014417392 3.394581e-01 4.833833e-01 7 129210508 129210548 41 + 2.336 2.398 0.205
ENSG00000128602 E022 431.653854 0.0002028849 4.886114e-03 1.561320e-02 7 129210965 129211113 149 + 2.530 2.616 0.288
ENSG00000128602 E023 3.346527 0.0493932356 4.269186e-01 5.697511e-01 7 129211114 129211128 15 + 0.667 0.556 -0.488
ENSG00000128602 E024 6.624877 0.0024563704 1.949478e-03 7.070375e-03 7 129211383 129211510 128 + 1.060 0.715 -1.323
ENSG00000128602 E025 324.638641 0.0002033655 2.964570e-05 1.766518e-04 7 129211636 129211770 135 + 2.378 2.504 0.419
ENSG00000128602 E026 5.043243 0.1377947461 2.566263e-01 3.936096e-01 7 129211771 129211815 45 + 0.869 0.665 -0.822
ENSG00000128602 E027 147.912860 0.0002248647 5.368460e-02 1.156975e-01 7 129212024 129212032 9 + 2.060 2.154 0.316
ENSG00000128602 E028 120.838819 0.0002939193 7.045805e-02 1.440962e-01 7 129212033 129212034 2 + 1.973 2.069 0.324
ENSG00000128602 E029 1939.771978 0.0037055521 1.525639e-08 1.817670e-07 7 129212035 129213545 1511 + 3.121 3.293 0.570