ENSG00000128596

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000460941 ENSG00000128596 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC136 protein_coding retained_intron 7.786156 8.425859 6.299107 0.3840133 0.1981995 -0.419099 0.5429825 0.3480966 0.56591171 0.09953455 0.17489022 0.6854990 0.07138333 0.04070000 0.090733333 0.05003333 0.3393259567 0.0006503817 FALSE FALSE
ENST00000464672 ENSG00000128596 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC136 protein_coding protein_coding 7.786156 8.425859 6.299107 0.3840133 0.1981995 -0.419099 0.3961733 0.8541644 0.15540498 0.35053127 0.06571437 -2.3853032 0.04658333 0.09833333 0.025266667 -0.07306667 0.2843428014 0.0006503817 FALSE TRUE
ENST00000471729 ENSG00000128596 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC136 protein_coding processed_transcript 7.786156 8.425859 6.299107 0.3840133 0.1981995 -0.419099 1.5077933 2.7116692 0.31630070 0.21872680 0.31630070 -3.0602177 0.16699167 0.32393333 0.051100000 -0.27283333 0.0659104027 0.0006503817 FALSE TRUE
ENST00000485832 ENSG00000128596 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC136 protein_coding retained_intron 7.786156 8.425859 6.299107 0.3840133 0.1981995 -0.419099 0.4253843 0.1444593 0.47877515 0.03388673 0.06173499 1.6619442 0.05752500 0.01726667 0.075833333 0.05856667 0.0009059751 0.0006503817 FALSE TRUE
ENST00000528772 ENSG00000128596 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC136 protein_coding retained_intron 7.786156 8.425859 6.299107 0.3840133 0.1981995 -0.419099 1.6388665 1.0557763 1.41065305 0.13517149 0.40920653 0.4146496 0.19879583 0.12450000 0.220400000 0.09590000 0.2994088756 0.0006503817   FALSE
MSTRG.30651.4 ENSG00000128596 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC136 protein_coding   7.786156 8.425859 6.299107 0.3840133 0.1981995 -0.419099 0.9267640 0.7877326 1.24047232 0.09203574 0.02029152 0.6484961 0.13052083 0.09333333 0.197133333 0.10380000 0.0006503817 0.0006503817 FALSE TRUE
MSTRG.30651.5 ENSG00000128596 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC136 protein_coding   7.786156 8.425859 6.299107 0.3840133 0.1981995 -0.419099 0.3527326 0.6678995 0.04532353 0.27423557 0.04532353 -3.6151063 0.04542500 0.07673333 0.007333333 -0.06940000 0.0978683762 0.0006503817 FALSE TRUE
MSTRG.30651.6 ENSG00000128596 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC136 protein_coding   7.786156 8.425859 6.299107 0.3840133 0.1981995 -0.419099 0.2983038 0.0000000 0.68514246 0.00000000 0.36069161 6.1192368 0.05359583 0.00000000 0.109200000 0.10920000 0.1579221206 0.0006503817 FALSE TRUE
MSTRG.30651.7 ENSG00000128596 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC136 protein_coding   7.786156 8.425859 6.299107 0.3840133 0.1981995 -0.419099 0.4218707 0.9004685 0.24208924 0.10877762 0.12118647 -1.8526745 0.05687917 0.10846667 0.037700000 -0.07076667 0.2915350242 0.0006503817 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000128596 E001 0.0000000       7 128790757 128790976 220 +      
ENSG00000128596 E002 0.0000000       7 128791364 128791409 46 +      
ENSG00000128596 E003 0.1472490 0.0429233673 3.831741e-01   7 128791410 128791418 9 + 0.136 0.000 -10.768
ENSG00000128596 E004 0.5503986 0.0207568011 7.266820e-01 8.196216e-01 7 128791419 128791422 4 + 0.136 0.197 0.638
ENSG00000128596 E005 0.6986918 0.0167317085 4.491743e-01 5.903781e-01 7 128791423 128791434 12 + 0.136 0.270 1.221
ENSG00000128596 E006 1.4360803 0.0132317065 7.326280e-01 8.240516e-01 7 128791435 128791442 8 + 0.324 0.387 0.375
ENSG00000128596 E007 1.4360803 0.0132317065 7.326280e-01 8.240516e-01 7 128791443 128791443 1 + 0.324 0.387 0.375
ENSG00000128596 E008 1.5833293 0.0142916935 9.588647e-01 9.782275e-01 7 128791444 128791449 6 + 0.394 0.387 -0.039
ENSG00000128596 E009 1.8757510 0.0129287437 4.746520e-01 6.134588e-01 7 128791450 128791457 8 + 0.507 0.387 -0.625
ENSG00000128596 E010 1.8757510 0.0129287437 4.746520e-01 6.134588e-01 7 128791458 128791469 12 + 0.507 0.387 -0.625
ENSG00000128596 E011 3.8204167 0.0743508906 8.171207e-02 1.622381e-01 7 128791470 128791474 5 + 0.839 0.519 -1.356
ENSG00000128596 E012 9.9336646 0.1086958342 1.411315e-01 2.495957e-01 7 128791475 128791551 77 + 1.165 0.896 -0.989
ENSG00000128596 E013 0.7770552 0.0149850461 8.795091e-01 9.266365e-01 7 128791618 128791886 269 + 0.240 0.269 0.218
ENSG00000128596 E014 0.2903454 0.3843008690 2.180641e-01   7 128791968 128792017 50 + 0.239 0.000 -11.766
ENSG00000128596 E015 0.2903454 0.3843008690 2.180641e-01   7 128792018 128792099 82 + 0.239 0.000 -11.766
ENSG00000128596 E016 0.8825757 0.0165354735 4.664156e-02 1.031918e-01 7 128792100 128792183 84 + 0.454 0.109 -2.688
ENSG00000128596 E017 0.5901540 0.0243880413 2.064725e-01 3.342927e-01 7 128792184 128792269 86 + 0.324 0.109 -1.952
ENSG00000128596 E018 0.1515154 0.0424686408 3.831189e-01   7 128792270 128792319 50 + 0.137 0.000 -10.772
ENSG00000128596 E019 16.2518559 0.0090114735 9.288450e-05 4.885527e-04 7 128792320 128792427 108 + 1.404 1.044 -1.274
ENSG00000128596 E020 0.0000000       7 128792428 128792428 1 +      
ENSG00000128596 E021 31.7731001 0.0051666934 6.869597e-03 2.088685e-02 7 128794348 128794602 255 + 1.604 1.424 -0.616
ENSG00000128596 E022 16.7835851 0.0026181941 3.253139e-01 4.687528e-01 7 128794694 128794768 75 + 1.281 1.202 -0.278
ENSG00000128596 E023 11.5625269 0.0024237612 1.903301e-01 3.141852e-01 7 128801186 128801209 24 + 1.155 1.032 -0.447
ENSG00000128596 E024 37.1299210 0.0008282428 1.055457e-01 1.989326e-01 7 128801210 128801473 264 + 1.615 1.528 -0.299
ENSG00000128596 E025 16.3594422 0.0011898418 6.263111e-01 7.422663e-01 7 128801474 128801509 36 + 1.246 1.210 -0.128
ENSG00000128596 E026 26.6445781 0.0016742095 2.036707e-01 3.307973e-01 7 128804650 128804761 112 + 1.372 1.464 0.320
ENSG00000128596 E027 33.6278300 0.0236562337 5.049826e-01 6.408289e-01 7 128805359 128805524 166 + 1.490 1.556 0.228
ENSG00000128596 E028 26.3486762 0.0067923990 9.788582e-01 9.908412e-01 7 128805761 128805847 87 + 1.423 1.432 0.031
ENSG00000128596 E029 23.7206066 0.0009279605 6.498997e-01 7.610315e-01 7 128805848 128805901 54 + 1.358 1.395 0.128
ENSG00000128596 E030 21.3867612 0.0009125834 6.323281e-02 1.320961e-01 7 128806237 128806374 138 + 1.417 1.287 -0.453
ENSG00000128596 E031 9.2051758 0.0155254353 3.185554e-01 4.615242e-01 7 128806375 128806395 21 + 1.069 0.955 -0.421
ENSG00000128596 E032 2.2678561 0.0086807774 8.484314e-03 2.499732e-02 7 128806396 128806687 292 + 0.704 0.270 -2.238
ENSG00000128596 E033 13.7150163 0.0157814713 5.617256e-01 6.894719e-01 7 128806688 128806746 59 + 1.121 1.184 0.227
ENSG00000128596 E034 14.1879597 0.0186051591 8.634641e-01 9.159360e-01 7 128806747 128806858 112 + 1.155 1.179 0.083
ENSG00000128596 E035 27.8901876 0.0017527603 2.250561e-01 3.564899e-01 7 128807360 128807545 186 + 1.398 1.485 0.298
ENSG00000128596 E036 4.3136862 0.0062000026 3.403722e-03 1.144910e-02 7 128807546 128807833 288 + 0.923 0.517 -1.688
ENSG00000128596 E037 4.7725079 0.0072383973 1.134536e-01 2.105631e-01 7 128809167 128809449 283 + 0.862 0.648 -0.866
ENSG00000128596 E038 20.6451223 0.0014524684 4.882882e-01 6.258735e-01 7 128809450 128809644 195 + 1.289 1.347 0.200
ENSG00000128596 E039 31.7967186 0.0074495969 4.145276e-01 5.579389e-01 7 128810139 128810366 228 + 1.530 1.476 -0.185
ENSG00000128596 E040 3.1762501 0.0051639696 7.350829e-01 8.259128e-01 7 128811262 128811352 91 + 0.636 0.588 -0.212
ENSG00000128596 E041 56.6125989 0.0038702905 8.785761e-01 9.260066e-01 7 128811800 128812312 513 + 1.746 1.742 -0.012
ENSG00000128596 E042 40.2236675 0.0006302954 1.616730e-01 2.772886e-01 7 128812708 128812929 222 + 1.553 1.635 0.280
ENSG00000128596 E043 14.1154822 0.0013614066 1.963871e-01 3.217085e-01 7 128814638 128814648 11 + 1.095 1.217 0.435
ENSG00000128596 E044 47.1756186 0.0005560693 2.191341e-01 3.493294e-01 7 128814649 128814919 271 + 1.627 1.694 0.229
ENSG00000128596 E045 28.1101361 0.0007582909 9.796137e-01 9.912981e-01 7 128815614 128815794 181 + 1.452 1.455 0.011
ENSG00000128596 E046 43.2387616 0.0015433527 7.467213e-03 2.243005e-02 7 128815795 128815931 137 + 1.539 1.694 0.526
ENSG00000128596 E047 6.2946798 0.0473781643 6.191443e-02 1.298407e-01 7 128817758 128817864 107 + 1.010 0.723 -1.108
ENSG00000128596 E048 14.6691728 0.0051020204 1.168898e-01 2.155355e-01 7 128817865 128818268 404 + 1.264 1.125 -0.493
ENSG00000128596 E049 59.9476693 0.0127010688 6.785213e-07 5.842370e-06 7 128821799 128822132 334 + 1.525 1.886 1.224