ENSG00000128595

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000249364 ENSG00000128595 HEK293_OSMI2_2hA HEK293_TMG_2hB CALU protein_coding protein_coding 84.04072 34.1694 131.4649 4.252923 2.450459 1.943589 10.934517 7.781900 17.20084 1.3171310 0.6727749 1.143270 0.16220833 0.22533333 0.1307333 -0.09460000 1.856864e-08 2.138315e-10 FALSE  
ENST00000449187 ENSG00000128595 HEK293_OSMI2_2hA HEK293_TMG_2hB CALU protein_coding protein_coding 84.04072 34.1694 131.4649 4.252923 2.450459 1.943589 39.339074 17.069319 56.90773 1.9893276 1.5632212 1.736628 0.47056250 0.50133333 0.4327667 -0.06856667 7.092784e-02 2.138315e-10 FALSE  
ENST00000479257 ENSG00000128595 HEK293_OSMI2_2hA HEK293_TMG_2hB CALU protein_coding protein_coding 84.04072 34.1694 131.4649 4.252923 2.450459 1.943589 5.547916 0.699878 13.62567 0.1581645 0.6996139 4.263671 0.04592083 0.02126667 0.1035000 0.08223333 3.902207e-07 2.138315e-10 FALSE  
ENST00000535011 ENSG00000128595 HEK293_OSMI2_2hA HEK293_TMG_2hB CALU protein_coding protein_coding 84.04072 34.1694 131.4649 4.252923 2.450459 1.943589 16.636568 6.719170 23.90588 1.0724339 0.7598629 1.829468 0.20673333 0.19570000 0.1818333 -0.01386667 8.286540e-01 2.138315e-10 FALSE  
MSTRG.30637.3 ENSG00000128595 HEK293_OSMI2_2hA HEK293_TMG_2hB CALU protein_coding   84.04072 34.1694 131.4649 4.252923 2.450459 1.943589 10.813715 1.811350 18.46481 0.2159612 0.4869662 3.342480 0.10515833 0.05356667 0.1407000 0.08713333 2.138315e-10 2.138315e-10 TRUE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000128595 E001 0.000000       7 128739292 128739311 20 +      
ENSG00000128595 E002 1.614668 0.0229342599 2.449433e-01 3.799723e-01 7 128739312 128739341 30 + 0.416 0.220 -1.284
ENSG00000128595 E003 6.285802 0.0027527670 5.528497e-01 6.820863e-01 7 128739342 128739358 17 + 0.810 0.797 -0.050
ENSG00000128595 E004 8.053015 0.0022845581 7.185608e-01 8.136247e-01 7 128739359 128739362 4 + 0.889 0.917 0.105
ENSG00000128595 E005 168.019372 0.0167629471 2.175992e-02 5.517655e-02 7 128739363 128739403 41 + 2.172 2.076 -0.322
ENSG00000128595 E006 231.282010 0.0124723574 9.697429e-04 3.854940e-03 7 128739404 128739432 29 + 2.317 2.183 -0.450
ENSG00000128595 E007 80.683631 0.0004343682 4.249734e-27 5.529528e-25 7 128747553 128748367 815 + 1.918 1.318 -2.046
ENSG00000128595 E008 769.789471 0.0075192574 3.061287e-06 2.285884e-05 7 128748573 128748804 232 + 2.838 2.702 -0.452
ENSG00000128595 E009 715.583637 0.0004075459 4.619408e-28 6.560217e-26 7 128754262 128754455 194 + 2.806 2.680 -0.420
ENSG00000128595 E010 187.490705 0.0001979769 1.867395e-05 1.166488e-04 7 128754529 128754722 194 + 2.212 2.159 -0.177
ENSG00000128595 E011 593.626360 0.0018978421 7.229607e-08 7.543662e-07 7 128758871 128758961 91 + 2.714 2.643 -0.236
ENSG00000128595 E012 565.510525 0.0022369962 1.754844e-06 1.382328e-05 7 128758962 128759037 76 + 2.691 2.627 -0.213
ENSG00000128595 E013 515.117861 0.0045198968 1.281416e-04 6.506928e-04 7 128759792 128759852 61 + 2.652 2.579 -0.243
ENSG00000128595 E014 1019.250812 0.0001252088 5.172208e-16 2.028694e-14 7 128767456 128767655 200 + 2.940 2.912 -0.095
ENSG00000128595 E015 773.093227 0.0001128135 2.250283e-05 1.378928e-04 7 128769063 128769196 134 + 2.811 2.830 0.063
ENSG00000128595 E016 4418.887348 0.0030423126 3.434493e-15 1.210745e-13 7 128769197 128771689 2493 + 3.514 3.717 0.672
ENSG00000128595 E017 100.427978 0.0006761173 5.472038e-04 2.336506e-03 7 128771690 128771788 99 + 1.874 2.096 0.746
ENSG00000128595 E018 210.699674 0.0001807879 1.571265e-12 3.726482e-11 7 128771789 128772511 723 + 2.175 2.447 0.908
ENSG00000128595 E019 283.280915 0.0088776634 4.155819e-10 6.605482e-09 7 128772512 128773400 889 + 2.248 2.657 1.363