ENSG00000128573

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000390668 ENSG00000128573 HEK293_OSMI2_2hA HEK293_TMG_2hB FOXP2 protein_coding protein_coding 2.436167 1.485407 3.643795 0.08285304 0.2833221 1.288857 0.07595657 0.00000000 0.2335184 0.00000000 0.23351838 4.60595879 0.01931667 0.00000000 0.05626667 0.05626667 9.452576e-01 2.031033e-13 FALSE TRUE
ENST00000393489 ENSG00000128573 HEK293_OSMI2_2hA HEK293_TMG_2hB FOXP2 protein_coding nonsense_mediated_decay 2.436167 1.485407 3.643795 0.08285304 0.2833221 1.288857 0.03613302 0.09209457 0.0000000 0.09209457 0.00000000 -3.35183425 0.01432500 0.06350000 0.00000000 -0.06350000 5.690509e-01 2.031033e-13 FALSE TRUE
ENST00000462331 ENSG00000128573 HEK293_OSMI2_2hA HEK293_TMG_2hB FOXP2 protein_coding protein_coding 2.436167 1.485407 3.643795 0.08285304 0.2833221 1.288857 0.10310487 0.11042445 0.2118807 0.01257804 0.09283707 0.88165592 0.05080000 0.07470000 0.05600000 -0.01870000 7.706829e-01 2.031033e-13   FALSE
ENST00000634664 ENSG00000128573 HEK293_OSMI2_2hA HEK293_TMG_2hB FOXP2 protein_coding processed_transcript 2.436167 1.485407 3.643795 0.08285304 0.2833221 1.288857 0.21268806 0.63278347 0.0000000 0.12660122 0.00000000 -6.00626093 0.15961667 0.42036667 0.00000000 -0.42036667 2.031033e-13 2.031033e-13   FALSE
ENST00000635638 ENSG00000128573 HEK293_OSMI2_2hA HEK293_TMG_2hB FOXP2 protein_coding protein_coding 2.436167 1.485407 3.643795 0.08285304 0.2833221 1.288857 0.05385625 0.00000000 0.3475553 0.00000000 0.34755526 5.16009431 0.01255833 0.00000000 0.08373333 0.08373333 9.509523e-01 2.031033e-13 FALSE TRUE
MSTRG.30535.10 ENSG00000128573 HEK293_OSMI2_2hA HEK293_TMG_2hB FOXP2 protein_coding   2.436167 1.485407 3.643795 0.08285304 0.2833221 1.288857 0.19424904 0.34449722 0.3542737 0.17401586 0.35427372 0.03924862 0.09727083 0.23300000 0.09813333 -0.13486667 5.260737e-01 2.031033e-13 FALSE TRUE
MSTRG.30535.2 ENSG00000128573 HEK293_OSMI2_2hA HEK293_TMG_2hB FOXP2 protein_coding   2.436167 1.485407 3.643795 0.08285304 0.2833221 1.288857 0.59005889 0.09000571 0.9401409 0.09000571 0.47371270 3.24805916 0.21046250 0.06206667 0.27976667 0.21770000 5.987830e-01 2.031033e-13 FALSE TRUE
MSTRG.30535.6 ENSG00000128573 HEK293_OSMI2_2hA HEK293_TMG_2hB FOXP2 protein_coding   2.436167 1.485407 3.643795 0.08285304 0.2833221 1.288857 0.27587755 0.00000000 0.4000575 0.00000000 0.20161066 5.35775446 0.10024167 0.00000000 0.11020000 0.11020000 3.283690e-01 2.031033e-13 FALSE TRUE
MSTRG.30535.7 ENSG00000128573 HEK293_OSMI2_2hA HEK293_TMG_2hB FOXP2 protein_coding   2.436167 1.485407 3.643795 0.08285304 0.2833221 1.288857 0.13721763 0.00000000 0.0910606 0.00000000 0.09106060 3.33714873 0.08504167 0.00000000 0.02523333 0.02523333 9.508031e-01 2.031033e-13 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000128573 E001 0.8114855 0.3483367803 5.232045e-01 6.569340e-01 7 114086327 114086398 72 + 0.199 0.322 0.920
ENSG00000128573 E002 0.9556140 0.3289443102 7.223240e-01 8.164706e-01 7 114086399 114086438 40 + 0.294 0.193 -0.790
ENSG00000128573 E003 0.5869198 0.2233274317 3.162433e-01 4.589941e-01 7 114086439 114086443 5 + 0.249 0.000 -13.480
ENSG00000128573 E004 1.1791501 0.0334447856 3.518585e-01 4.960598e-01 7 114086444 114086498 55 + 0.372 0.189 -1.313
ENSG00000128573 E005 0.4407149 0.0218070266 7.773150e-01 8.566957e-01 7 114086499 114086500 2 + 0.142 0.189 0.495
ENSG00000128573 E006 2.4293759 0.0449117559 2.085572e-01 3.367499e-01 7 114086501 114086559 59 + 0.569 0.321 -1.308
ENSG00000128573 E007 4.0450867 0.0697166021 5.037944e-01 6.397283e-01 7 114086560 114086611 52 + 0.704 0.574 -0.561
ENSG00000128573 E008 0.1515154 0.0423440837 1.000000e+00   7 114087747 114087771 25 + 0.077 0.000 -11.977
ENSG00000128573 E009 0.4783925 0.0208008698 7.741735e-01 8.543915e-01 7 114087772 114087838 67 + 0.142 0.189 0.497
ENSG00000128573 E010 0.2214452 0.0382333520 1.666191e-01   7 114088166 114088270 105 + 0.000 0.190 12.774
ENSG00000128573 E011 10.3384347 0.0379574075 9.396173e-01 9.660863e-01 7 114162944 114163040 97 + 1.012 1.018 0.021
ENSG00000128573 E012 9.1195438 0.0908584759 7.377783e-01 8.278588e-01 7 114163041 114163088 48 + 0.951 0.999 0.180
ENSG00000128573 E013 1.2596890 0.0109085507 9.349519e-01 9.630587e-01 7 114285405 114285456 52 + 0.335 0.321 -0.088
ENSG00000128573 E014 7.0490618 0.0640303436 6.650594e-01 7.727767e-01 7 114288019 114288030 12 + 0.890 0.815 -0.289
ENSG00000128573 E015 12.8254468 0.0016605396 7.531010e-01 8.391427e-01 7 114288031 114288109 79 + 1.108 1.077 -0.111
ENSG00000128573 E016 0.2924217 0.0276779454 6.659276e-01   7 114366505 114366640 136 + 0.142 0.000 -12.942
ENSG00000128573 E017 0.0000000       7 114414274 114414542 269 +      
ENSG00000128573 E018 0.0000000       7 114414815 114414996 182 +      
ENSG00000128573 E019 0.1451727 0.0428389116 1.000000e+00   7 114414997 114415057 61 + 0.077 0.000 -11.975
ENSG00000128573 E020 0.1451727 0.0428389116 1.000000e+00   7 114415058 114415111 54 + 0.077 0.000 -11.975
ENSG00000128573 E021 0.4355181 0.5794862992 6.797881e-01 7.838716e-01 7 114415112 114415219 108 + 0.198 0.000 -12.840
ENSG00000128573 E022 0.5870335 0.0962129639 2.823155e-01 4.222930e-01 7 114415220 114415318 99 + 0.249 0.000 -13.656
ENSG00000128573 E023 0.2966881 0.0274424043 6.680502e-01   7 114415319 114415322 4 + 0.142 0.000 -12.943
ENSG00000128573 E024 0.2966881 0.0274424043 6.680502e-01   7 114415323 114415360 38 + 0.142 0.000 -12.943
ENSG00000128573 E025 0.0000000       7 114416286 114416427 142 +      
ENSG00000128573 E026 0.0000000       7 114426500 114426501 2 +      
ENSG00000128573 E027 8.2255708 0.0021539392 2.097625e-01 3.382613e-01 7 114426502 114426514 13 + 0.970 0.811 -0.607
ENSG00000128573 E028 17.8480023 0.0010900988 7.302096e-02 1.483671e-01 7 114426515 114426679 165 + 1.279 1.115 -0.582
ENSG00000128573 E029 0.1472490 0.0447753256 1.000000e+00   7 114463074 114463171 98 + 0.077 0.000 -11.969
ENSG00000128573 E030 3.1314287 0.0058625313 7.075349e-01 8.054342e-01 7 114498883 114499093 211 + 0.570 0.631 0.275
ENSG00000128573 E031 3.4300889 0.0047154255 1.194049e-02 3.338857e-02 7 114499094 114499728 635 + 0.468 0.846 1.634
ENSG00000128573 E032 13.0101185 0.0176709142 6.154350e-02 1.292340e-01 7 114534617 114534706 90 + 1.169 0.937 -0.849
ENSG00000128573 E033 2.1079362 0.0071897861 2.840509e-01 4.242590e-01 7 114538326 114538383 58 + 0.522 0.321 -1.089
ENSG00000128573 E034 2.3282235 0.0081720232 2.277979e-01 3.597924e-01 7 114570807 114570881 75 + 0.546 0.321 -1.203
ENSG00000128573 E035 11.8618968 0.0015900317 1.098117e-01 2.052863e-01 7 114628540 114628677 138 + 1.114 0.937 -0.649
ENSG00000128573 E036 0.0000000       7 114628678 114628982 305 +      
ENSG00000128573 E037 0.2934659 0.0293550260 4.510220e-01   7 114629592 114629642 51 + 0.077 0.189 1.495
ENSG00000128573 E038 0.2998086 0.0292330196 4.511535e-01   7 114629787 114629804 18 + 0.077 0.189 1.494
ENSG00000128573 E039 5.7721332 0.0028337410 7.904851e-01 8.659871e-01 7 114629805 114629853 49 + 0.808 0.772 -0.141
ENSG00000128573 E040 3.2580407 0.0050806227 4.438192e-01 5.854027e-01 7 114629854 114629855 2 + 0.633 0.503 -0.590
ENSG00000128573 E041 3.5610715 0.0073248565 3.235504e-01 4.668722e-01 7 114629856 114629864 9 + 0.670 0.503 -0.751
ENSG00000128573 E042 3.3396263 0.0070932062 1.572267e-01 2.714072e-01 7 114629865 114629867 3 + 0.670 0.422 -1.167
ENSG00000128573 E043 5.3399380 0.0131232771 7.333490e-01 8.245737e-01 7 114629868 114629944 77 + 0.781 0.731 -0.203
ENSG00000128573 E044 4.1208316 0.0139129468 3.679095e-01 5.123031e-01 7 114629945 114630005 61 + 0.633 0.772 0.577
ENSG00000128573 E045 0.0000000       7 114630611 114630613 3 +      
ENSG00000128573 E046 1.6681517 0.0080320569 5.306057e-01 6.631964e-01 7 114631528 114631530 3 + 0.438 0.321 -0.674
ENSG00000128573 E047 1.6681517 0.0080320569 5.306057e-01 6.631964e-01 7 114631531 114631536 6 + 0.438 0.321 -0.674
ENSG00000128573 E048 1.8164449 0.0077506182 9.207686e-01 9.540253e-01 7 114631537 114631542 6 + 0.438 0.421 -0.089
ENSG00000128573 E049 1.9679603 0.0080655800 7.934364e-01 8.679269e-01 7 114631543 114631545 3 + 0.468 0.421 -0.241
ENSG00000128573 E050 10.9512114 0.0016781164 1.133948e-02 3.197579e-02 7 114631546 114631705 160 + 1.114 0.811 -1.135
ENSG00000128573 E051 20.2653796 0.0008956690 5.153367e-05 2.894254e-04 7 114642410 114642623 214 + 1.374 0.989 -1.373
ENSG00000128573 E052 13.8445118 0.0031714839 3.192217e-04 1.457805e-03 7 114644685 114644789 105 + 1.228 0.811 -1.540
ENSG00000128573 E053 0.1482932 0.0418468877 1.678126e-01   7 114644790 114645830 1041 + 0.000 0.189 12.755
ENSG00000128573 E054 13.1310280 0.0013103363 2.300062e-03 8.150824e-03 7 114652203 114652290 88 + 1.191 0.846 -1.272
ENSG00000128573 E055 15.5740277 0.0015350574 1.451871e-01 2.550941e-01 7 114653926 114654009 84 + 1.217 1.077 -0.503
ENSG00000128573 E056 0.3030308 0.3253455612 7.764708e-01   7 114654010 114654143 134 + 0.143 0.000 -12.478
ENSG00000128573 E057 0.0000000       7 114656440 114656594 155 +      
ENSG00000128573 E058 22.1238615 0.0010775955 1.112161e-02 3.145658e-02 7 114658066 114658267 202 + 1.381 1.166 -0.754
ENSG00000128573 E059 15.4345439 0.0016288883 2.983021e-01 4.397419e-01 7 114659356 114659432 77 + 1.212 1.115 -0.348
ENSG00000128573 E060 16.6214101 0.0011521450 1.387170e-01 2.463282e-01 7 114659572 114659673 102 + 1.252 1.115 -0.487
ENSG00000128573 E061 0.0000000       7 114661792 114661913 122 +      
ENSG00000128573 E062 19.9580163 0.0009654123 2.057021e-02 5.269301e-02 7 114662065 114662186 122 + 1.337 1.133 -0.721
ENSG00000128573 E063 11.9264289 0.0014828387 1.657229e-01 2.826379e-01 7 114663450 114663519 70 + 1.114 0.964 -0.550
ENSG00000128573 E064 17.6751643 0.0010658263 5.661785e-01 6.931949e-01 7 114664273 114664436 164 + 1.247 1.198 -0.174
ENSG00000128573 E065 0.2214452 0.0382333520 1.666191e-01   7 114664437 114669984 5548 + 0.000 0.190 12.774
ENSG00000128573 E066 224.2600745 0.0004056876 9.060266e-27 1.145057e-24 7 114689782 114693772 3991 + 2.239 2.449 0.700