ENSG00000128512

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000423057 ENSG00000128512 HEK293_OSMI2_2hA HEK293_TMG_2hB DOCK4 protein_coding protein_coding 1.815689 1.04207 2.802245 0.1012063 0.1946259 1.418492 0.04255747 0.07405632 0.00000000 0.07405632 0.00000000 -3.0713563 0.03336250 0.06160000 0.000000000 -0.0616000 5.335982e-01 3.67353e-08 FALSE TRUE
ENST00000437633 ENSG00000128512 HEK293_OSMI2_2hA HEK293_TMG_2hB DOCK4 protein_coding protein_coding 1.815689 1.04207 2.802245 0.1012063 0.1946259 1.418492 1.05833029 0.35185850 1.82215065 0.03544546 0.11813084 2.3400406 0.51823333 0.34176667 0.651300000 0.3095333 9.428222e-04 3.67353e-08 FALSE TRUE
ENST00000445943 ENSG00000128512 HEK293_OSMI2_2hA HEK293_TMG_2hB DOCK4 protein_coding protein_coding 1.815689 1.04207 2.802245 0.1012063 0.1946259 1.418492 0.06683386 0.00000000 0.27274583 0.00000000 0.15703403 4.8214338 0.02440417 0.00000000 0.097200000 0.0972000 3.811599e-01 3.67353e-08 FALSE TRUE
ENST00000450156 ENSG00000128512 HEK293_OSMI2_2hA HEK293_TMG_2hB DOCK4 protein_coding protein_coding 1.815689 1.04207 2.802245 0.1012063 0.1946259 1.418492 0.11041045 0.00000000 0.25806141 0.00000000 0.14956748 4.7444917 0.06840000 0.00000000 0.100466667 0.1004667 4.144447e-01 3.67353e-08 FALSE TRUE
ENST00000486186 ENSG00000128512 HEK293_OSMI2_2hA HEK293_TMG_2hB DOCK4 protein_coding retained_intron 1.815689 1.04207 2.802245 0.1012063 0.1946259 1.418492 0.16590602 0.09907797 0.17061229 0.03538033 0.07639201 0.7275363 0.10705833 0.09063333 0.058033333 -0.0326000 7.777066e-01 3.67353e-08 FALSE TRUE
ENST00000658652 ENSG00000128512 HEK293_OSMI2_2hA HEK293_TMG_2hB DOCK4 protein_coding protein_coding 1.815689 1.04207 2.802245 0.1012063 0.1946259 1.418492 0.15825323 0.41829589 0.02363826 0.03912405 0.02363826 -3.6704326 0.14789583 0.41170000 0.007733333 -0.4039667 3.673530e-08 3.67353e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000128512 E001 0.8824740 0.355624168 3.585581e-01 5.029711e-01 7 111726110 111726153 44 - 0.183 0.436 1.722
ENSG00000128512 E002 18.1714833 0.051165934 7.248539e-10 1.103870e-08 7 111726154 111726690 537 - 0.821 1.667 3.016
ENSG00000128512 E003 6.7287055 0.007672148 2.439950e-07 2.299707e-06 7 111726691 111726746 56 - 0.539 1.207 2.622
ENSG00000128512 E004 8.3988464 0.024455489 3.831333e-05 2.218727e-04 7 111726747 111726823 77 - 0.702 1.252 2.062
ENSG00000128512 E005 69.1391022 0.011724612 5.203820e-05 2.919128e-04 7 111726824 111728273 1450 - 1.696 1.979 0.956
ENSG00000128512 E006 10.0749933 0.001767139 1.679795e-01 2.855713e-01 7 111728274 111728420 147 - 0.940 1.116 0.645
ENSG00000128512 E007 20.5916006 0.010313331 6.455146e-01 7.576033e-01 7 111728421 111728720 300 - 1.264 1.332 0.240
ENSG00000128512 E008 10.9452521 0.029789128 6.054341e-01 7.258244e-01 7 111732226 111732287 62 - 0.998 1.096 0.361
ENSG00000128512 E009 1.0049449 0.057270167 6.029058e-01 7.237872e-01 7 111732288 111732514 227 - 0.231 0.345 0.788
ENSG00000128512 E010 14.8140311 0.004033204 5.253296e-01 6.587074e-01 7 111735054 111735167 114 - 1.117 1.207 0.320
ENSG00000128512 E011 12.0725890 0.002034848 7.376648e-01 8.277741e-01 7 111736917 111736989 73 - 1.034 1.096 0.226
ENSG00000128512 E012 16.3420667 0.001164107 5.446918e-01 6.751122e-01 7 111739134 111739243 110 - 1.156 1.238 0.291
ENSG00000128512 E013 1.5918621 0.009936571 4.242320e-02 9.548925e-02 7 111739244 111739395 152 - 0.231 0.605 2.107
ENSG00000128512 E014 14.0587714 0.007543866 9.941958e-01 1.000000e+00 7 111739396 111739477 82 - 1.112 1.137 0.093
ENSG00000128512 E015 3.2987236 0.097121318 5.746950e-01 7.004667e-01 7 111739478 111740214 737 - 0.539 0.672 0.587
ENSG00000128512 E016 12.6944817 0.027004865 9.551942e-01 9.758814e-01 7 111741094 111741214 121 - 1.075 1.098 0.085
ENSG00000128512 E017 11.7926398 0.001594265 8.911369e-01 9.344656e-01 7 111741540 111741661 122 - 1.034 1.075 0.147
ENSG00000128512 E018 11.5481275 0.001638643 9.404475e-01 9.666120e-01 7 111742013 111742132 120 - 1.034 1.052 0.064
ENSG00000128512 E019 9.3378069 0.001920955 7.511701e-01 8.376845e-01 7 111746334 111746417 84 - 0.940 1.003 0.231
ENSG00000128512 E020 15.3578755 0.008742761 7.318324e-01 8.234109e-01 7 111747267 111747443 177 - 1.145 1.206 0.218
ENSG00000128512 E021 10.8905699 0.012874013 6.608181e-01 7.694247e-01 7 111755515 111755601 87 - 0.997 1.076 0.287
ENSG00000128512 E022 14.3486037 0.001321124 7.627193e-01 8.462762e-01 7 111758624 111758790 167 - 1.117 1.173 0.198
ENSG00000128512 E023 9.0863606 0.001961626 6.415605e-01 7.545612e-01 7 111760181 111760223 43 - 0.949 0.917 -0.123
ENSG00000128512 E024 9.7968100 0.002504451 2.623067e-01 4.000839e-01 7 111760224 111760322 99 - 0.998 0.884 -0.428
ENSG00000128512 E025 4.9157086 0.075069169 8.808966e-01 9.276392e-01 7 111765118 111765154 37 - 0.717 0.723 0.023
ENSG00000128512 E026 8.7505405 0.022592945 2.162841e-01 3.459359e-01 7 111765155 111765222 68 - 0.966 0.811 -0.595
ENSG00000128512 E027 9.9026206 0.035447363 3.380743e-01 4.819422e-01 7 111767032 111767080 49 - 1.006 0.888 -0.444
ENSG00000128512 E028 8.5612337 0.002981797 1.907818e-01 3.147307e-01 7 111767081 111767118 38 - 0.958 0.809 -0.570
ENSG00000128512 E029 12.0161664 0.002279639 1.521358e-01 2.645865e-01 7 111769529 111769656 128 - 1.087 0.947 -0.515
ENSG00000128512 E030 5.8002218 0.002864370 2.710542e-01 4.097543e-01 7 111769657 111769677 21 - 0.809 0.665 -0.585
ENSG00000128512 E031 10.7450742 0.001863056 7.554218e-01 8.407596e-01 7 111778276 111778369 94 - 1.013 1.003 -0.037
ENSG00000128512 E032 8.4459083 0.009287865 7.178969e-01 8.131598e-01 7 111782864 111782924 61 - 0.904 0.976 0.269
ENSG00000128512 E033 9.6127517 0.001801914 9.209788e-01 9.541215e-01 7 111783857 111783952 96 - 0.966 1.002 0.135
ENSG00000128512 E034 0.1451727 0.043394517 1.000000e+00   7 111784097 111784123 27 - 0.070 0.000 -9.319
ENSG00000128512 E035 0.0000000       7 111784384 111784479 96 -      
ENSG00000128512 E036 0.0000000       7 111788501 111788661 161 -      
ENSG00000128512 E037 7.7951478 0.002163305 7.011307e-01 8.004093e-01 7 111788662 111788747 86 - 0.875 0.947 0.274
ENSG00000128512 E038 0.1482932 0.042528975 1.416178e-01   7 111788748 111789024 277 - 0.000 0.205 11.765
ENSG00000128512 E039 0.0000000       7 111789235 111789260 26 -      
ENSG00000128512 E040 8.4511541 0.002083722 8.624709e-01 9.153207e-01 7 111790457 111790605 149 - 0.913 0.916 0.012
ENSG00000128512 E041 7.1898984 0.011629785 7.289973e-02 1.481637e-01 7 111808821 111808879 59 - 0.914 0.665 -0.989
ENSG00000128512 E042 9.4471308 0.006651633 2.005167e-01 3.268483e-01 7 111809301 111809401 101 - 0.990 0.848 -0.536
ENSG00000128512 E043 7.6879448 0.005526392 1.096043e-01 2.049874e-01 7 111811874 111811949 76 - 0.923 0.719 -0.799
ENSG00000128512 E044 7.3176122 0.044539676 2.149993e-01 3.444363e-01 7 111822362 111822456 95 - 0.903 0.723 -0.709
ENSG00000128512 E045 7.1369374 0.099536492 4.601801e-01 6.002379e-01 7 111834588 111834686 99 - 0.873 0.779 -0.369
ENSG00000128512 E046 0.0000000       7 111840763 111840870 108 -      
ENSG00000128512 E047 8.5888302 0.004702935 3.935046e-02 8.982042e-02 7 111844763 111844897 135 - 0.982 0.718 -1.023
ENSG00000128512 E048 10.8897062 0.003631262 6.249331e-01 7.411494e-01 7 111846999 111847126 128 - 1.034 1.002 -0.118
ENSG00000128512 E049 0.0000000       7 111862883 111863371 489 -      
ENSG00000128512 E050 12.2736328 0.013157694 2.285003e-01 3.606280e-01 7 111863372 111863564 193 - 1.100 0.975 -0.457
ENSG00000128512 E051 9.7113658 0.004912447 1.389333e-01 2.466244e-01 7 111867984 111868154 171 - 1.013 0.848 -0.623
ENSG00000128512 E052 0.0000000       7 111869460 111869573 114 -      
ENSG00000128512 E053 8.6520150 0.003323447 7.474524e-01 8.349555e-01 7 111869574 111869655 82 - 0.932 0.916 -0.057
ENSG00000128512 E054 9.1752303 0.003116080 4.966917e-01 6.333253e-01 7 111871990 111872090 101 - 0.923 1.028 0.391
ENSG00000128512 E055 8.2348054 0.002608914 8.822569e-01 9.286221e-01 7 111872269 111872352 84 - 0.904 0.947 0.161
ENSG00000128512 E056 8.8281802 0.001916665 8.142177e-01 8.822819e-01 7 111872467 111872564 98 - 0.923 0.976 0.198
ENSG00000128512 E057 11.1553767 0.001503277 7.084643e-02 1.447546e-01 7 111877030 111877186 157 - 1.075 0.883 -0.712
ENSG00000128512 E058 9.4903480 0.001846314 1.154926e-02 3.246394e-02 7 111895612 111895718 107 - 1.034 0.718 -1.217
ENSG00000128512 E059 9.8895473 0.002563871 8.396437e-03 2.478003e-02 7 111900374 111900536 163 - 1.048 0.718 -1.267
ENSG00000128512 E060 10.9345837 0.019890102 1.243944e-01 2.262438e-01 7 111901677 111901801 125 - 1.068 0.883 -0.688
ENSG00000128512 E061 11.1048007 0.018807565 5.617854e-02 1.200155e-01 7 111915779 111915904 126 - 1.087 0.846 -0.901
ENSG00000128512 E062 0.0000000       7 111935108 111935539 432 -      
ENSG00000128512 E063 9.7513316 0.007403591 1.332665e-01 2.386649e-01 7 111935540 111935628 89 - 1.020 0.847 -0.650
ENSG00000128512 E064 11.1071041 0.036783535 4.675172e-02 1.033836e-01 7 111940110 111940242 133 - 1.087 0.810 -1.042
ENSG00000128512 E065 9.2381286 0.041764935 4.397314e-01 5.814804e-01 7 111944811 111944871 61 - 0.982 0.885 -0.364
ENSG00000128512 E066 9.6537376 0.055401058 5.890950e-01 7.121899e-01 7 111945717 111945798 82 - 0.997 0.916 -0.304
ENSG00000128512 E067 0.2214452 0.036500079 1.410682e-01   7 111976538 111977131 594 - 0.000 0.206 11.788
ENSG00000128512 E068 11.2542357 0.004631068 3.766429e-01 5.209643e-01 7 111977132 111977283 152 - 1.055 0.976 -0.292
ENSG00000128512 E069 9.3015312 0.022641437 2.306859e-01 3.632753e-01 7 111984306 111984390 85 - 0.998 0.846 -0.573
ENSG00000128512 E070 10.3956547 0.020890105 1.315403e-03 5.028028e-03 7 111989015 111989163 149 - 1.088 0.604 -1.898
ENSG00000128512 E071 8.0701583 0.002154123 7.668770e-03 2.294853e-02 7 111994135 111994231 97 - 0.974 0.604 -1.480
ENSG00000128512 E072 4.3005520 0.004441454 8.240385e-02 1.633035e-01 7 111998448 111998503 56 - 0.731 0.449 -1.276
ENSG00000128512 E073 4.4569886 0.036632549 3.888526e-03 1.283195e-02 7 112000494 112000534 41 - 0.784 0.205 -3.073
ENSG00000128512 E074 5.8263508 0.005928927 2.161896e-04 1.033445e-03 7 112004048 112004131 84 - 0.884 0.205 -3.464
ENSG00000128512 E075 5.7800372 0.018199264 5.255789e-02 1.137147e-01 7 112206102 112206407 306 - 0.843 0.534 -1.301