ENSG00000128487

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000395525 ENSG00000128487 HEK293_OSMI2_2hA HEK293_TMG_2hB SPECC1 protein_coding protein_coding 7.454935 6.472483 8.648242 0.5155813 0.1037144 0.4175275 0.4437993 0.2241016 0.3703276 0.2241016 0.3703276 0.7001080 0.05964583 0.03386667 0.04190000 0.008033333 0.976624445 0.001969914 FALSE TRUE
ENST00000395527 ENSG00000128487 HEK293_OSMI2_2hA HEK293_TMG_2hB SPECC1 protein_coding protein_coding 7.454935 6.472483 8.648242 0.5155813 0.1037144 0.4175275 0.0829888 0.3213961 0.0000000 0.1753641 0.0000000 -5.0504848 0.01302500 0.05476667 0.00000000 -0.054766667 0.001969914 0.001969914 FALSE TRUE
ENST00000395530 ENSG00000128487 HEK293_OSMI2_2hA HEK293_TMG_2hB SPECC1 protein_coding protein_coding 7.454935 6.472483 8.648242 0.5155813 0.1037144 0.4175275 0.9652736 0.9905850 1.9359831 0.5469119 0.1809653 0.9596554 0.12639167 0.16366667 0.22426667 0.060600000 0.754710369 0.001969914 FALSE TRUE
ENST00000580934 ENSG00000128487 HEK293_OSMI2_2hA HEK293_TMG_2hB SPECC1 protein_coding protein_coding 7.454935 6.472483 8.648242 0.5155813 0.1037144 0.4175275 1.1927069 0.0000000 2.1388373 0.0000000 1.0841280 7.7474125 0.14478750 0.00000000 0.24746667 0.247466667 0.206990732 0.001969914 FALSE TRUE
ENST00000581399 ENSG00000128487 HEK293_OSMI2_2hA HEK293_TMG_2hB SPECC1 protein_coding protein_coding 7.454935 6.472483 8.648242 0.5155813 0.1037144 0.4175275 1.1463192 1.3077118 0.1277787 0.7140342 0.1277787 -3.2576100 0.16746250 0.19086667 0.01446667 -0.176400000 0.384778198 0.001969914 FALSE TRUE
ENST00000583482 ENSG00000128487 HEK293_OSMI2_2hA HEK293_TMG_2hB SPECC1 protein_coding protein_coding 7.454935 6.472483 8.648242 0.5155813 0.1037144 0.4175275 1.4478243 1.3950798 0.9565391 0.7718404 0.9565391 -0.5397520 0.19308333 0.19853333 0.11100000 -0.087533333 0.509679253 0.001969914 FALSE TRUE
ENST00000679740 ENSG00000128487 HEK293_OSMI2_2hA HEK293_TMG_2hB SPECC1 protein_coding protein_coding 7.454935 6.472483 8.648242 0.5155813 0.1037144 0.4175275 0.8196708 1.0610553 1.7145201 0.2650213 0.1753255 0.6871620 0.10612500 0.17186667 0.19836667 0.026500000 0.814484377 0.001969914 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000128487 E001 0.0000000       17 20008262 20008864 603 +      
ENSG00000128487 E002 0.0000000       17 20008865 20008869 5 +      
ENSG00000128487 E003 0.8126314 0.0153787590 1.628055e-01 2.787993e-01 17 20008870 20009319 450 + 0.369 0.119 -2.085
ENSG00000128487 E004 0.2944980 0.3524414969 2.812523e-01   17 20009320 20009343 24 + 0.223 0.000 -13.733
ENSG00000128487 E005 0.2944980 0.3524414969 2.812523e-01   17 20009344 20009345 2 + 0.223 0.000 -13.733
ENSG00000128487 E006 0.2944980 0.3524414969 2.812523e-01   17 20009346 20009346 1 + 0.223 0.000 -13.733
ENSG00000128487 E007 0.2944980 0.3524414969 2.812523e-01   17 20009347 20009352 6 + 0.223 0.000 -13.733
ENSG00000128487 E008 0.2944980 0.3524414969 2.812523e-01   17 20009353 20009358 6 + 0.223 0.000 -13.733
ENSG00000128487 E009 0.2944980 0.3524414969 2.812523e-01   17 20009359 20009359 1 + 0.223 0.000 -13.733
ENSG00000128487 E010 0.2944980 0.3524414969 2.812523e-01   17 20009360 20009363 4 + 0.223 0.000 -13.733
ENSG00000128487 E011 0.2944980 0.3524414969 2.812523e-01   17 20009364 20009365 2 + 0.223 0.000 -13.733
ENSG00000128487 E012 0.2944980 0.3524414969 2.812523e-01   17 20009366 20009367 2 + 0.223 0.000 -13.733
ENSG00000128487 E013 3.8634074 0.0041149304 7.121856e-03 2.154159e-02 17 20009368 20009378 11 + 0.867 0.462 -1.749
ENSG00000128487 E014 6.1841372 0.0086804348 1.931326e-01 3.177041e-01 17 20009379 20009424 46 + 0.940 0.759 -0.700
ENSG00000128487 E015 0.5202097 0.0207501747 5.544739e-01 6.834537e-01 17 20009863 20010217 355 + 0.223 0.119 -1.084
ENSG00000128487 E016 0.1515154 0.0434805606 4.805080e-01   17 20010335 20010652 318 + 0.126 0.000 -13.607
ENSG00000128487 E017 1.5209001 0.0212630771 7.754190e-01 8.553298e-01 17 20017145 20017605 461 + 0.370 0.412 0.236
ENSG00000128487 E018 4.1683998 0.0055671150 2.980554e-02 7.158067e-02 17 20017987 20018102 116 + 0.867 0.547 -1.335
ENSG00000128487 E019 1.2543904 0.0108647759 4.586395e-01 5.989499e-01 17 20057677 20057771 95 + 0.428 0.289 -0.824
ENSG00000128487 E020 1.0360657 0.0346234021 6.733111e-01 7.790345e-01 17 20057772 20057817 46 + 0.369 0.288 -0.510
ENSG00000128487 E021 0.6599951 0.0176236801 3.980158e-02 9.065790e-02 17 20067194 20067378 185 + 0.000 0.354 14.709
ENSG00000128487 E022 0.0000000       17 20073538 20073555 18 +      
ENSG00000128487 E023 0.0000000       17 20073556 20073564 9 +      
ENSG00000128487 E024 0.0000000       17 20073565 20073701 137 +      
ENSG00000128487 E025 0.0000000       17 20087021 20087021 1 +      
ENSG00000128487 E026 0.0000000       17 20087022 20087051 30 +      
ENSG00000128487 E027 0.0000000       17 20095692 20095692 1 +      
ENSG00000128487 E028 0.0000000       17 20095693 20095912 220 +      
ENSG00000128487 E029 0.0000000       17 20095913 20096037 125 +      
ENSG00000128487 E030 5.5940838 0.0489078068 4.047368e-01 5.484391e-01 17 20096631 20096635 5 + 0.886 0.738 -0.585
ENSG00000128487 E031 5.8971147 0.0116617684 1.891330e-01 3.126450e-01 17 20096636 20096651 16 + 0.923 0.735 -0.734
ENSG00000128487 E032 9.9599053 0.0043011271 1.845923e-01 3.069657e-01 17 20096652 20096798 147 + 1.116 0.964 -0.556
ENSG00000128487 E033 9.4428928 0.0315607628 1.139996e-01 2.113528e-01 17 20110427 20110562 136 + 1.127 0.901 -0.834
ENSG00000128487 E034 0.0000000       17 20124900 20124997 98 +      
ENSG00000128487 E035 0.0000000       17 20155338 20155511 174 +      
ENSG00000128487 E036 0.0000000       17 20155742 20155877 136 +      
ENSG00000128487 E037 0.0000000       17 20155989 20155993 5 +      
ENSG00000128487 E038 0.1451727 0.0432263125 4.812617e-01   17 20155994 20156014 21 + 0.126 0.000 -13.608
ENSG00000128487 E039 1.2909221 0.0101959520 9.681787e-01 9.841160e-01 17 20156015 20156050 36 + 0.369 0.355 -0.087
ENSG00000128487 E040 1.6209197 0.0085969537 5.617486e-01 6.894885e-01 17 20156051 20156057 7 + 0.369 0.461 0.498
ENSG00000128487 E041 3.6461123 0.0055795011 1.321926e-01 2.371610e-01 17 20156058 20156082 25 + 0.780 0.547 -0.993
ENSG00000128487 E042 9.2077390 0.0233116358 6.403417e-01 7.535956e-01 17 20156083 20156088 6 + 1.044 0.966 -0.286
ENSG00000128487 E043 48.1312498 0.0026009726 2.219800e-02 5.608172e-02 17 20156089 20156236 148 + 1.761 1.621 -0.475
ENSG00000128487 E044 237.4000329 0.0073555708 3.974416e-07 3.584752e-06 17 20204333 20205739 1407 + 2.487 2.257 -0.769
ENSG00000128487 E045 33.3248959 0.0006238629 2.343625e-02 5.865471e-02 17 20205740 20205795 56 + 1.608 1.459 -0.509
ENSG00000128487 E046 47.2091902 0.0004763698 7.423046e-03 2.231933e-02 17 20205796 20205912 117 + 1.756 1.607 -0.504
ENSG00000128487 E047 135.9084131 0.0002603144 2.221865e-01 3.530157e-01 17 20227413 20227620 208 + 2.163 2.113 -0.166
ENSG00000128487 E048 91.8522992 0.0007493354 3.128205e-01 4.553466e-01 17 20231758 20231831 74 + 1.955 1.979 0.081
ENSG00000128487 E049 140.4893493 0.0046789010 1.973200e-01 3.228850e-01 17 20232200 20232405 206 + 2.127 2.169 0.139
ENSG00000128487 E050 2.1358439 0.0068804445 4.395025e-01 5.812589e-01 17 20232406 20232414 9 + 0.428 0.547 0.591
ENSG00000128487 E051 0.0000000       17 20232415 20232451 37 +      
ENSG00000128487 E052 21.0946208 0.0256351670 1.397864e-01 2.477326e-01 17 20236860 20236899 40 + 1.258 1.407 0.521
ENSG00000128487 E053 96.5161905 0.0150206089 1.362508e-02 3.736745e-02 17 20236900 20239427 2528 + 2.077 1.897 -0.604
ENSG00000128487 E054 0.1472490 0.0433210655 4.810463e-01   17 20244124 20245925 1802 + 0.126 0.000 -13.608
ENSG00000128487 E055 53.7850154 0.0017204933 4.034087e-02 9.165156e-02 17 20245926 20246071 146 + 1.687 1.778 0.308
ENSG00000128487 E056 0.1472490 0.0433210655 4.810463e-01   17 20246072 20246197 126 + 0.126 0.000 -13.608
ENSG00000128487 E057 0.0000000       17 20246198 20246574 377 +      
ENSG00000128487 E058 0.1817044 0.0398438781 4.955584e-01   17 20246575 20247218 644 + 0.000 0.119 12.608
ENSG00000128487 E059 37.0423289 0.0006102357 8.773833e-02 1.717053e-01 17 20247219 20247319 101 + 1.530 1.614 0.287
ENSG00000128487 E060 1.2209923 0.0108647759 4.567615e-01 5.971353e-01 17 20247320 20248932 1613 + 0.428 0.289 -0.825
ENSG00000128487 E061 39.4433487 0.0005466513 2.657816e-02 6.511339e-02 17 20253505 20253586 82 + 1.542 1.652 0.374
ENSG00000128487 E062 60.9123379 0.0004073224 8.404358e-03 2.479916e-02 17 20257451 20257607 157 + 1.730 1.834 0.353
ENSG00000128487 E063 62.5453819 0.0029481799 5.969179e-02 1.260962e-01 17 20260192 20260294 103 + 1.753 1.834 0.273
ENSG00000128487 E064 56.8378146 0.0089130068 2.008092e-01 3.272004e-01 17 20296961 20297077 117 + 1.719 1.787 0.229
ENSG00000128487 E065 0.0000000       17 20305652 20306000 349 +      
ENSG00000128487 E066 0.1817044 0.0398438781 4.955584e-01   17 20306001 20306022 22 + 0.000 0.119 12.608
ENSG00000128487 E067 47.1184997 0.0069637357 1.778936e-03 6.532548e-03 17 20306023 20306082 60 + 1.563 1.751 0.639
ENSG00000128487 E068 5.1444034 0.0030766226 1.316875e-04 6.663052e-04 17 20306083 20308261 2179 + 1.002 0.462 -2.256
ENSG00000128487 E069 291.6326109 0.0024390376 8.504068e-11 1.519591e-09 17 20313976 20319026 5051 + 2.364 2.531 0.558