ENSG00000128311

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000249042 ENSG00000128311 HEK293_OSMI2_2hA HEK293_TMG_2hB TST protein_coding protein_coding 81.79781 168.7102 40.1908 6.151035 0.4051182 -2.069336 72.110898 150.68141 33.659522 4.340189 0.1990289 -2.162082 0.8652167 0.89366667 0.8376000 -0.05606667 0.0027197831 0.0009543533 FALSE  
ENST00000403892 ENSG00000128311 HEK293_OSMI2_2hA HEK293_TMG_2hB TST protein_coding protein_coding 81.79781 168.7102 40.1908 6.151035 0.4051182 -2.069336 8.204341 14.45243 6.188855 1.790937 0.3229130 -1.222236 0.1195458 0.08523333 0.1538667 0.06863333 0.0009543533 0.0009543533 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000128311 E001 1.686608 0.0098940393 5.040696e-01 6.399681e-01 22 37010859 37010864 6 - 0.232 0.371 0.930
ENSG00000128311 E002 1798.069958 0.0025957485 5.744306e-01 7.002409e-01 22 37010865 37011325 461 - 3.099 3.109 0.033
ENSG00000128311 E003 1326.183655 0.0001916496 8.073360e-02 1.606962e-01 22 37018138 37018360 223 - 2.957 2.976 0.062
ENSG00000128311 E004 1236.244722 0.0015577270 2.854110e-01 4.257299e-01 22 37018361 37018753 393 - 2.928 2.947 0.064
ENSG00000128311 E005 216.207116 0.0063622973 1.119975e-07 1.127696e-06 22 37018754 37019399 646 - 2.388 2.141 -0.823
ENSG00000128311 E006 216.703159 0.0044030524 4.167813e-01 5.601643e-01 22 37019400 37019467 68 - 2.219 2.183 -0.121
ENSG00000128311 E007 7.849997 0.0266878505 4.487390e-01 5.899982e-01 22 37019583 37019640 58 - 0.907 0.789 -0.457
ENSG00000128311 E008 0.000000       22 37020162 37020183 22 -