ENSG00000128191

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000351989 ENSG00000128191 HEK293_OSMI2_2hA HEK293_TMG_2hB DGCR8 protein_coding protein_coding 39.10326 48.95779 34.30006 1.090218 0.938801 -0.5132016 15.255338 24.870200 16.17182946 3.2182477 0.11320174 -0.62062338 0.40155000 0.50933333 0.472100000 -0.03723333 0.86580789 0.01403494 FALSE  
ENST00000407755 ENSG00000128191 HEK293_OSMI2_2hA HEK293_TMG_2hB DGCR8 protein_coding protein_coding 39.10326 48.95779 34.30006 1.090218 0.938801 -0.5132016 1.995790 2.520739 0.06392058 1.2647709 0.06392058 -5.09743876 0.05018750 0.05116667 0.001966667 -0.04920000 0.37910551 0.01403494 FALSE  
ENST00000475941 ENSG00000128191 HEK293_OSMI2_2hA HEK293_TMG_2hB DGCR8 protein_coding retained_intron 39.10326 48.95779 34.30006 1.090218 0.938801 -0.5132016 2.524311 2.952093 1.18712032 0.3120001 0.26100779 -1.30704877 0.05738750 0.06026667 0.034966667 -0.02530000 0.20805615 0.01403494 FALSE  
ENST00000491892 ENSG00000128191 HEK293_OSMI2_2hA HEK293_TMG_2hB DGCR8 protein_coding retained_intron 39.10326 48.95779 34.30006 1.090218 0.938801 -0.5132016 5.890722 4.563005 5.84435700 0.6862078 0.68566576 0.35636825 0.15059583 0.09270000 0.169700000 0.07700000 0.01403494 0.01403494 FALSE  
ENST00000495351 ENSG00000128191 HEK293_OSMI2_2hA HEK293_TMG_2hB DGCR8 protein_coding retained_intron 39.10326 48.95779 34.30006 1.090218 0.938801 -0.5132016 2.100099 1.340901 1.95239053 0.1560824 0.32240315 0.53868974 0.05416250 0.02733333 0.056566667 0.02923333 0.02776074 0.01403494 FALSE  
ENST00000495826 ENSG00000128191 HEK293_OSMI2_2hA HEK293_TMG_2hB DGCR8 protein_coding retained_intron 39.10326 48.95779 34.30006 1.090218 0.938801 -0.5132016 2.946676 2.145131 2.26426343 0.3289556 0.23035299 0.07762372 0.07553333 0.04356667 0.065733333 0.02216667 0.23022086 0.01403494 TRUE  
ENST00000498171 ENSG00000128191 HEK293_OSMI2_2hA HEK293_TMG_2hB DGCR8 protein_coding retained_intron 39.10326 48.95779 34.30006 1.090218 0.938801 -0.5132016 6.893781 9.298984 5.45650728 1.6109634 0.39306149 -0.76800433 0.17425000 0.18970000 0.158933333 -0.03076667 0.78122104 0.01403494 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000128191 E001 0.7331471 0.0172671820 1.101242e-01 2.057140e-01 22 20080232 20080240 9 + 0.000 0.311 15.012
ENSG00000128191 E002 62.0797047 0.0330662845 9.692243e-01 9.847666e-01 22 20080241 20080383 143 + 1.755 1.791 0.123
ENSG00000128191 E003 3.2881238 0.0055522325 6.580607e-01 7.672752e-01 22 20080569 20080685 117 + 0.628 0.588 -0.175
ENSG00000128191 E004 68.2881214 0.0241819133 6.202927e-01 7.375037e-01 22 20085687 20085745 59 + 1.823 1.818 -0.016
ENSG00000128191 E005 65.3956364 0.0193824734 7.569113e-01 8.418884e-01 22 20085746 20085819 74 + 1.791 1.808 0.058
ENSG00000128191 E006 33.2588487 0.0317129841 6.491806e-01 7.605074e-01 22 20085820 20085821 2 + 1.524 1.513 -0.039
ENSG00000128191 E007 181.8255168 0.0055385854 1.198643e-04 6.133298e-04 22 20085822 20086057 236 + 2.320 2.189 -0.438
ENSG00000128191 E008 150.3225777 0.0078611390 2.472939e-04 1.164039e-03 22 20086058 20086142 85 + 2.249 2.098 -0.504
ENSG00000128191 E009 199.4827140 0.0058426341 5.048032e-04 2.178091e-03 22 20086143 20086339 197 + 2.351 2.237 -0.383
ENSG00000128191 E010 356.8639234 0.0020463316 1.647878e-03 6.113974e-03 22 20086340 20086683 344 + 2.564 2.513 -0.168
ENSG00000128191 E011 40.6301440 0.0087511069 5.533705e-04 2.359169e-03 22 20086684 20087035 352 + 1.717 1.509 -0.708
ENSG00000128191 E012 26.9431059 0.0007850485 2.446718e-06 1.867464e-05 22 20087036 20087161 126 + 1.583 1.308 -0.950
ENSG00000128191 E013 287.0809640 0.0016660201 2.481518e-04 1.167497e-03 22 20087162 20087321 160 + 2.479 2.413 -0.218
ENSG00000128191 E014 260.8486744 0.0001932106 6.880008e-13 1.733932e-11 22 20089669 20089811 143 + 2.472 2.349 -0.410
ENSG00000128191 E015 48.4506991 0.0080866974 6.892526e-15 2.329234e-13 22 20089812 20089975 164 + 1.919 1.436 -1.641
ENSG00000128191 E016 363.4226797 0.0017527167 5.164903e-04 2.221334e-03 22 20089976 20090258 283 + 2.576 2.521 -0.183
ENSG00000128191 E017 267.8942804 0.0016366043 5.170784e-01 6.515414e-01 22 20091435 20091632 198 + 2.394 2.414 0.065
ENSG00000128191 E018 190.2677573 0.0013568096 9.660112e-01 9.826365e-01 22 20091869 20091970 102 + 2.231 2.271 0.133
ENSG00000128191 E019 242.2226675 0.0002338460 7.046082e-01 8.031160e-01 22 20092809 20092907 99 + 2.345 2.375 0.100
ENSG00000128191 E020 3.0502088 0.0841122791 6.415417e-02 1.336196e-01 22 20094712 20094712 1 + 0.769 0.451 -1.419
ENSG00000128191 E021 266.1408692 0.0010131303 4.136067e-01 5.570635e-01 22 20094713 20094795 83 + 2.395 2.412 0.058
ENSG00000128191 E022 137.0609055 0.0024127868 9.343005e-01 9.625709e-01 22 20106177 20106181 5 + 2.096 2.132 0.119
ENSG00000128191 E023 261.9705182 0.0002228583 4.855145e-01 6.233914e-01 22 20106182 20106277 96 + 2.385 2.408 0.077
ENSG00000128191 E024 2.3668409 0.0061362378 6.598427e-01 7.685865e-01 22 20106567 20106591 25 + 0.536 0.490 -0.220
ENSG00000128191 E025 318.0385694 0.0005849866 7.305847e-01 8.224858e-01 22 20106592 20106685 94 + 2.462 2.494 0.105
ENSG00000128191 E026 185.1729389 0.0019698112 4.798229e-01 6.181596e-01 22 20106686 20106698 13 + 2.239 2.255 0.054
ENSG00000128191 E027 51.4694626 0.0113212448 1.724686e-04 8.458685e-04 22 20106699 20107036 338 + 1.829 1.602 -0.771
ENSG00000128191 E028 362.3007776 0.0009876841 1.784376e-01 2.991928e-01 22 20107271 20107398 128 + 2.492 2.564 0.241
ENSG00000128191 E029 25.9672732 0.0013666005 1.249347e-02 3.471932e-02 22 20107399 20107571 173 + 1.492 1.356 -0.470
ENSG00000128191 E030 126.2623073 0.0002725542 3.887059e-06 2.835220e-05 22 20107572 20108889 1318 + 2.150 2.040 -0.369
ENSG00000128191 E031 352.2754928 0.0002093997 4.063587e-04 1.799183e-03 22 20108890 20109003 114 + 2.450 2.563 0.374
ENSG00000128191 E032 10.0570660 0.0017595968 9.982927e-02 1.902211e-01 22 20109004 20109184 181 + 1.106 0.971 -0.493
ENSG00000128191 E033 2001.9886262 0.0027899474 4.775955e-17 2.133436e-15 22 20110025 20111877 1853 + 3.129 3.344 0.715