ENSG00000128185

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000248879 ENSG00000128185 HEK293_OSMI2_2hA HEK293_TMG_2hB DGCR6L protein_coding protein_coding 223.239 464.2308 93.70824 19.7546 2.725755 -2.308472 197.90771 420.09671 79.23235 17.817457 2.8451115 -2.406412 0.87363333 0.90493333 0.8452 -0.05973333 2.558262e-09 2.558262e-09 FALSE  
ENST00000443409 ENSG00000128185 HEK293_OSMI2_2hA HEK293_TMG_2hB DGCR6L protein_coding nonsense_mediated_decay 223.239 464.2308 93.70824 19.7546 2.725755 -2.308472 18.73283 31.92639 11.57416 2.334931 0.2629636 -1.463047 0.09537083 0.06863333 0.1238 0.05516667 4.543314e-08 2.558262e-09    
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000128185 E001 75.662997 0.0090174139 0.116784214 0.21536892 22 20314238 20314282 45 - 1.592 1.720 0.435
ENSG00000128185 E002 175.971143 0.0109483907 0.244009598 0.37891201 22 20314283 20314296 14 - 1.993 2.077 0.280
ENSG00000128185 E003 321.036122 0.0106872423 0.081940639 0.16260582 22 20314297 20314322 26 - 2.228 2.338 0.368
ENSG00000128185 E004 812.341686 0.0023369342 0.008275492 0.02447991 22 20314323 20314389 67 - 2.655 2.737 0.271
ENSG00000128185 E005 780.486158 0.0018897368 0.065836262 0.13643355 22 20314390 20314393 4 - 2.663 2.716 0.178
ENSG00000128185 E006 823.892817 0.0017113960 0.051697147 0.11217737 22 20314394 20314400 7 - 2.685 2.740 0.181
ENSG00000128185 E007 3711.156326 0.0008226079 0.009597535 0.02777203 22 20314401 20314824 424 - 3.351 3.390 0.131
ENSG00000128185 E008 3220.869392 0.0001807972 0.074662554 0.15099811 22 20315336 20315476 141 - 3.337 3.321 -0.053
ENSG00000128185 E009 75.596575 0.0053357210 0.195581876 0.32069171 22 20315477 20315520 44 - 1.776 1.694 -0.276
ENSG00000128185 E010 2478.156479 0.0005561765 0.748127754 0.83546364 22 20316119 20316219 101 - 3.211 3.209 -0.007
ENSG00000128185 E011 2949.112795 0.0011508115 0.041202919 0.09325667 22 20319639 20319786 148 - 3.312 3.282 -0.101
ENSG00000128185 E012 978.311179 0.0018750721 0.104733920 0.19771576 22 20319787 20319789 3 - 2.840 2.801 -0.129
ENSG00000128185 E013 956.271525 0.0004956887 0.003029992 0.01035432 22 20319790 20319799 10 - 2.843 2.788 -0.181
ENSG00000128185 E014 1617.516259 0.0028838914 0.276625093 0.41608081 22 20319879 20320098 220 - 3.047 3.022 -0.085
ENSG00000128185 E015 5.289953 0.0032088471 0.200562027 0.32690810 22 20320242 20321140 899 - 0.816 0.610 -0.851