ENSG00000127980

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000248633 ENSG00000127980 HEK293_OSMI2_2hA HEK293_TMG_2hB PEX1 protein_coding protein_coding 11.04589 3.111082 17.40544 0.1224303 0.5602609 2.480249 2.3473362 1.51697212 3.5998946 0.46768868 0.60247169 1.241283 0.29568333 0.496566667 0.20926667 -0.2873000000 2.889812e-01 1.659361e-09 FALSE TRUE
ENST00000428214 ENSG00000127980 HEK293_OSMI2_2hA HEK293_TMG_2hB PEX1 protein_coding protein_coding 11.04589 3.111082 17.40544 0.1224303 0.5602609 2.480249 1.6099457 0.01698529 2.9224605 0.01698529 0.18672767 6.763795 0.09565417 0.005400000 0.16890000 0.1635000000 1.659361e-09 1.659361e-09 FALSE TRUE
ENST00000438045 ENSG00000127980 HEK293_OSMI2_2hA HEK293_TMG_2hB PEX1 protein_coding protein_coding 11.04589 3.111082 17.40544 0.1224303 0.5602609 2.480249 0.2606690 0.69152387 0.1877041 0.36470682 0.05577968 -1.827149 0.06513750 0.215533333 0.01093333 -0.2046000000 1.878485e-01 1.659361e-09 FALSE TRUE
ENST00000469417 ENSG00000127980 HEK293_OSMI2_2hA HEK293_TMG_2hB PEX1 protein_coding retained_intron 11.04589 3.111082 17.40544 0.1224303 0.5602609 2.480249 0.9043168 0.20820397 1.1613645 0.15179857 0.15842899 2.424441 0.08485833 0.065533333 0.06636667 0.0008333333 8.186262e-01 1.659361e-09 FALSE FALSE
ENST00000477342 ENSG00000127980 HEK293_OSMI2_2hA HEK293_TMG_2hB PEX1 protein_coding retained_intron 11.04589 3.111082 17.40544 0.1224303 0.5602609 2.480249 0.7925159 0.35889616 0.8911925 0.06437905 0.16881552 1.288621 0.08907083 0.116000000 0.05130000 -0.0647000000 1.016793e-01 1.659361e-09   FALSE
ENST00000484913 ENSG00000127980 HEK293_OSMI2_2hA HEK293_TMG_2hB PEX1 protein_coding retained_intron 11.04589 3.111082 17.40544 0.1224303 0.5602609 2.480249 1.5903811 0.02160600 2.4792182 0.02160600 0.73490810 6.299351 0.10551667 0.006866667 0.14146667 0.1346000000 5.729276e-03 1.659361e-09 FALSE TRUE
ENST00000496420 ENSG00000127980 HEK293_OSMI2_2hA HEK293_TMG_2hB PEX1 protein_coding retained_intron 11.04589 3.111082 17.40544 0.1224303 0.5602609 2.480249 0.7717258 0.17853006 1.1204372 0.02167643 0.07585790 2.584014 0.07453750 0.057166667 0.06426667 0.0071000000 8.235050e-01 1.659361e-09 TRUE TRUE
MSTRG.30215.4 ENSG00000127980 HEK293_OSMI2_2hA HEK293_TMG_2hB PEX1 protein_coding   11.04589 3.111082 17.40544 0.1224303 0.5602609 2.480249 2.6206712 0.11836497 4.8070349 0.06499068 0.57329717 5.229822 0.17738333 0.036966667 0.27483333 0.2378666667 1.942740e-05 1.659361e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000127980 E001 0.2965864 0.2544183260 2.760709e-02   7 92487020 92487024 5 - 0.000 0.381 12.331
ENSG00000127980 E002 0.2965864 0.2544183260 2.760709e-02   7 92487025 92487025 1 - 0.000 0.381 14.717
ENSG00000127980 E003 24.3350684 0.0055547420 4.290066e-27 5.578175e-25 7 92487026 92487289 264 - 0.965 1.815 2.967
ENSG00000127980 E004 19.1699415 0.0054668840 1.031676e-14 3.386725e-13 7 92487290 92487296 7 - 0.965 1.640 2.376
ENSG00000127980 E005 53.9063687 0.0004807532 6.341287e-23 5.577241e-21 7 92487297 92487456 160 - 1.478 1.990 1.734
ENSG00000127980 E006 75.2224872 0.0003875666 5.341842e-11 9.866394e-10 7 92487457 92487541 85 - 1.703 2.012 1.040
ENSG00000127980 E007 79.6195444 0.0004573867 1.334718e-06 1.078997e-05 7 92489293 92489371 79 - 1.752 1.983 0.779
ENSG00000127980 E008 77.0328545 0.0084599213 5.325667e-02 1.149439e-01 7 92489372 92489423 52 - 1.764 1.903 0.468
ENSG00000127980 E009 6.6943371 0.0057624350 8.285386e-01 8.922384e-01 7 92489424 92489713 290 - 0.788 0.831 0.169
ENSG00000127980 E010 48.9398225 0.0019776775 5.483076e-03 1.724328e-02 7 92489714 92489718 5 - 1.559 1.741 0.619
ENSG00000127980 E011 122.5001238 0.0098370728 1.071675e-01 2.013563e-01 7 92489719 92489911 193 - 1.970 2.082 0.377
ENSG00000127980 E012 6.7330618 0.0068997337 7.515201e-01 8.379479e-01 7 92489912 92490246 335 - 0.818 0.781 -0.146
ENSG00000127980 E013 113.5367512 0.0002901312 2.618995e-01 3.996278e-01 7 92491272 92491502 231 - 1.948 2.006 0.194
ENSG00000127980 E014 88.0465865 0.0003732327 5.585572e-01 6.867818e-01 7 92492953 92493129 177 - 1.841 1.881 0.134
ENSG00000127980 E015 29.5249679 0.0014690187 6.136497e-02 1.289305e-01 7 92493130 92494292 1163 - 1.414 1.263 -0.527
ENSG00000127980 E016 59.5098873 0.0031554310 1.049447e-02 2.996632e-02 7 92494293 92494396 104 - 1.712 1.552 -0.543
ENSG00000127980 E017 62.3719703 0.0026066160 3.597388e-02 8.353017e-02 7 92494487 92494629 143 - 1.724 1.602 -0.413
ENSG00000127980 E018 51.5279825 0.0004958371 9.823745e-02 1.878474e-01 7 92496713 92496777 65 - 1.638 1.543 -0.323
ENSG00000127980 E019 68.4958519 0.0003983217 3.940088e-04 1.751626e-03 7 92499704 92499838 135 - 1.775 1.577 -0.671
ENSG00000127980 E020 69.1295651 0.0003998536 1.850931e-02 4.825085e-02 7 92501507 92501673 167 - 1.768 1.646 -0.411
ENSG00000127980 E021 3.3290026 0.0046746518 8.371809e-01 8.981946e-01 7 92501674 92501767 94 - 0.544 0.590 0.211
ENSG00000127980 E022 5.0242243 0.0034314982 7.398396e-01 8.294465e-01 7 92501768 92501889 122 - 0.708 0.663 -0.189
ENSG00000127980 E023 57.2294214 0.0004238260 9.858927e-02 1.883395e-01 7 92501890 92502079 190 - 1.682 1.594 -0.301
ENSG00000127980 E024 51.7323157 0.0004731085 1.152796e-01 2.132669e-01 7 92503041 92503195 155 - 1.641 1.552 -0.303
ENSG00000127980 E025 52.9924531 0.0005033923 3.956678e-01 5.394735e-01 7 92504732 92504886 155 - 1.642 1.602 -0.138
ENSG00000127980 E026 26.9228303 0.0008161471 4.845438e-01 6.225075e-01 7 92504887 92504902 16 - 1.359 1.311 -0.167
ENSG00000127980 E027 54.5216229 0.0004529814 2.758296e-01 4.152147e-01 7 92506248 92506344 97 - 1.656 1.602 -0.186
ENSG00000127980 E028 12.7593256 0.0016076814 1.884109e-01 3.117260e-01 7 92506345 92506993 649 - 1.069 0.915 -0.570
ENSG00000127980 E029 53.8642548 0.0004193657 9.312350e-01 9.606840e-01 7 92506994 92507126 133 - 1.639 1.646 0.024
ENSG00000127980 E030 1.0632359 0.0116547049 8.404763e-01 9.004367e-01 7 92507127 92507823 697 - 0.274 0.236 -0.288
ENSG00000127980 E031 30.7476282 0.0006737518 7.605281e-01 8.446117e-01 7 92509329 92509411 83 - 1.407 1.395 -0.042
ENSG00000127980 E032 0.5954526 0.0183627556 5.135245e-01 6.483378e-01 7 92510865 92510943 79 - 0.201 0.000 -14.345
ENSG00000127980 E033 35.6295713 0.0005686381 9.999455e-01 1.000000e+00 7 92510944 92511047 104 - 1.463 1.475 0.042
ENSG00000127980 E034 52.4345398 0.0004082701 5.361728e-04 2.295101e-03 7 92511580 92511703 124 - 1.666 1.442 -0.765
ENSG00000127980 E035 56.8940218 0.0003972490 2.692509e-04 1.254549e-03 7 92513848 92513967 120 - 1.702 1.475 -0.773
ENSG00000127980 E036 182.2443856 0.0002844147 7.934726e-13 1.981297e-11 7 92517276 92518042 767 - 2.203 1.950 -0.850
ENSG00000127980 E037 46.3762770 0.0014816292 6.309786e-05 3.466549e-04 7 92518141 92518255 115 - 1.623 1.326 -1.019
ENSG00000127980 E038 1.9156227 0.0077579519 3.175725e-01 4.604734e-01 7 92518960 92518994 35 - 0.441 0.236 -1.288
ENSG00000127980 E039 32.9157505 0.0013390629 3.297289e-04 1.499716e-03 7 92518995 92519078 84 - 1.480 1.168 -1.091
ENSG00000127980 E040 42.4537870 0.0006775877 1.308201e-06 1.059530e-05 7 92522102 92522245 144 - 1.596 1.208 -1.344
ENSG00000127980 E041 29.3770817 0.0007718716 5.415036e-04 2.315455e-03 7 92528307 92528520 214 - 1.436 1.123 -1.099