ENSG00000127946

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000336926 ENSG00000127946 HEK293_OSMI2_2hA HEK293_TMG_2hB HIP1 protein_coding protein_coding 6.339945 7.060724 6.859477 0.580844 0.1932541 -0.04165758 5.5169711 5.79817586 6.0530411 0.62756802 0.03327822 0.06195646 0.86988333 0.818066667 0.88363333 0.06556667 3.134468e-01 2.030034e-05 FALSE TRUE
ENST00000479835 ENSG00000127946 HEK293_OSMI2_2hA HEK293_TMG_2hB HIP1 protein_coding processed_transcript 6.339945 7.060724 6.859477 0.580844 0.1932541 -0.04165758 0.4866425 1.05880426 0.3101806 0.04468497 0.04888583 -1.73903982 0.07862083 0.151333333 0.04503333 -0.10630000 2.030034e-05 2.030034e-05 FALSE TRUE
MSTRG.30073.3 ENSG00000127946 HEK293_OSMI2_2hA HEK293_TMG_2hB HIP1 protein_coding   6.339945 7.060724 6.859477 0.580844 0.1932541 -0.04165758 0.2817006 0.03651859 0.4962556 0.01418264 0.13533829 3.44398666 0.04286667 0.004933333 0.07133333 0.06640000 7.607612e-04 2.030034e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000127946 E001 259.2613682 0.0102753412 7.172234e-17 3.140911e-15 7 75533298 75534087 790 - 2.131 2.588 1.526
ENSG00000127946 E002 650.1815784 0.0002644369 1.126834e-28 1.686219e-26 7 75534088 75537594 3507 - 2.712 2.897 0.615
ENSG00000127946 E003 86.3586032 0.0004002882 1.919516e-03 6.976030e-03 7 75537595 75538082 488 - 1.976 1.901 -0.252
ENSG00000127946 E004 45.6953269 0.0060152346 4.811620e-02 1.058359e-01 7 75538083 75538224 142 - 1.704 1.620 -0.288
ENSG00000127946 E005 43.7155070 0.0007522738 6.019613e-04 2.540427e-03 7 75539323 75539431 109 - 1.712 1.569 -0.484
ENSG00000127946 E006 38.4560378 0.0006394731 2.082362e-03 7.479364e-03 7 75541919 75541980 62 - 1.656 1.525 -0.449
ENSG00000127946 E007 41.5916497 0.0005567309 6.225235e-02 1.304261e-01 7 75542851 75542974 124 - 1.656 1.598 -0.199
ENSG00000127946 E008 37.1568918 0.0055203446 2.339723e-01 3.671049e-01 7 75544695 75544800 106 - 1.596 1.562 -0.117
ENSG00000127946 E009 33.0884774 0.0073152060 1.563497e-01 2.702677e-01 7 75545088 75545188 101 - 1.559 1.502 -0.196
ENSG00000127946 E010 34.4002638 0.0006364652 1.260491e-01 2.286489e-01 7 75546939 75547032 94 - 1.573 1.525 -0.165
ENSG00000127946 E011 36.3720641 0.0023316817 6.503265e-03 1.993083e-02 7 75547755 75547813 59 - 1.630 1.506 -0.425
ENSG00000127946 E012 44.4857314 0.0005521837 6.930653e-04 2.873633e-03 7 75548891 75549001 111 - 1.722 1.586 -0.462
ENSG00000127946 E013 49.4965249 0.0006906648 1.545160e-04 7.670814e-04 7 75553453 75553589 137 - 1.770 1.621 -0.504
ENSG00000127946 E014 36.8304790 0.0006134567 2.709948e-04 1.261714e-03 7 75554113 75554220 108 - 1.654 1.485 -0.574
ENSG00000127946 E015 26.6540070 0.0009821368 6.078667e-03 1.881798e-02 7 75554440 75554526 87 - 1.511 1.368 -0.491
ENSG00000127946 E016 36.3805966 0.0009917249 3.452283e-03 1.158817e-02 7 75555416 75555551 136 - 1.630 1.501 -0.442
ENSG00000127946 E017 38.6805817 0.0008162355 7.060699e-04 2.920458e-03 7 75556026 75556169 144 - 1.662 1.511 -0.516
ENSG00000127946 E018 26.8401368 0.0039898892 5.218738e-02 1.130521e-01 7 75556710 75556811 102 - 1.486 1.389 -0.336
ENSG00000127946 E019 34.9748733 0.0097495513 9.147687e-03 2.665050e-02 7 75557654 75557770 117 - 1.622 1.472 -0.512
ENSG00000127946 E020 25.1897707 0.0060345861 4.025601e-02 9.150375e-02 7 75558167 75558221 55 - 1.470 1.356 -0.394
ENSG00000127946 E021 21.8512678 0.0234873402 8.721306e-02 1.709140e-01 7 75558222 75558255 34 - 1.414 1.290 -0.431
ENSG00000127946 E022 35.2700277 0.0013950123 1.404287e-04 7.054276e-04 7 75559732 75559915 184 - 1.642 1.454 -0.644
ENSG00000127946 E023 28.2121809 0.0006885812 4.010491e-03 1.317226e-02 7 75561329 75561401 73 - 1.534 1.388 -0.501
ENSG00000127946 E024 33.1594864 0.0006832376 1.285445e-03 4.928232e-03 7 75562073 75562170 98 - 1.606 1.453 -0.521
ENSG00000127946 E025 36.4516848 0.0006043825 3.602909e-02 8.364150e-02 7 75562935 75563075 141 - 1.612 1.534 -0.267
ENSG00000127946 E026 19.0544851 0.0011527611 4.184563e-02 9.444167e-02 7 75563188 75563263 76 - 1.362 1.245 -0.409
ENSG00000127946 E027 0.0000000       7 75563264 75563385 122 -      
ENSG00000127946 E028 20.9043928 0.0009656449 5.417432e-04 2.316166e-03 7 75568199 75568256 58 - 1.438 1.218 -0.769
ENSG00000127946 E029 30.2801858 0.0007019609 4.240471e-03 1.381433e-02 7 75573761 75573901 141 - 1.563 1.425 -0.472
ENSG00000127946 E030 17.9800472 0.0120483243 1.688423e-01 2.866742e-01 7 75581237 75581298 62 - 1.327 1.242 -0.299
ENSG00000127946 E031 12.6513908 0.0330510702 1.580540e-01 2.725331e-01 7 75582075 75582091 17 - 1.203 1.078 -0.449
ENSG00000127946 E032 20.4157524 0.0088318640 2.656173e-02 6.507649e-02 7 75582092 75582151 60 - 1.404 1.253 -0.528
ENSG00000127946 E033 24.5318788 0.0008037578 1.165554e-04 5.980952e-04 7 75586753 75586833 81 - 1.503 1.271 -0.802
ENSG00000127946 E034 20.7579861 0.0009375720 5.455683e-05 3.045085e-04 7 75592056 75592112 57 - 1.447 1.178 -0.940
ENSG00000127946 E035 29.5687155 0.0006794602 1.186357e-07 1.188912e-06 7 75592372 75592514 143 - 1.609 1.304 -1.051
ENSG00000127946 E036 21.9251203 0.0012540440 2.338978e-04 1.107947e-03 7 75599184 75599247 64 - 1.461 1.227 -0.813
ENSG00000127946 E037 0.0000000       7 75611666 75611843 178 -      
ENSG00000127946 E038 4.6410423 0.0686960846 1.077172e-01 2.021686e-01 7 75639051 75639235 185 - 0.856 0.592 -1.088
ENSG00000127946 E039 0.5180316 0.0284625669 6.935068e-02 1.422877e-01 7 75654413 75654696 284 - 0.000 0.318 10.775
ENSG00000127946 E040 5.9292226 0.0028793912 1.474011e-04 7.359357e-04 7 75733460 75733800 341 - 0.485 1.031 2.245
ENSG00000127946 E041 17.6277552 0.0010995062 9.062391e-01 9.444047e-01 7 75738801 75738962 162 - 1.249 1.280 0.109