ENSG00000127837

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000248450 ENSG00000127837 HEK293_OSMI2_2hA HEK293_TMG_2hB AAMP protein_coding protein_coding 288.7186 462.6925 184.4176 18.15776 1.168013 -1.327031 221.27066 368.80984 132.17577 15.606837 0.6730480 -1.480349 0.7549250 0.7969000 0.7167667 -0.080133333 3.487251e-12 1.446737e-23 FALSE  
ENST00000444053 ENSG00000127837 HEK293_OSMI2_2hA HEK293_TMG_2hB AAMP protein_coding protein_coding 288.7186 462.6925 184.4176 18.15776 1.168013 -1.327031 42.09762 66.79915 27.45729 0.571153 0.9398064 -1.282331 0.1462542 0.1447333 0.1488000 0.004066667 8.907653e-01 1.446737e-23 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000127837 E001 8.01773 2.144060e-03 2.003595e-05 1.242594e-04 2 218264129 218264129 1 - 0.194 0.968 3.879
ENSG00000127837 E002 29.60626 1.396310e-03 4.239125e-07 3.803948e-06 2 218264130 218264136 7 - 1.000 1.477 1.686
ENSG00000127837 E003 40.69794 6.648780e-04 2.539363e-09 3.492375e-08 2 218264137 218264142 6 - 1.126 1.610 1.681
ENSG00000127837 E004 45.03757 5.124866e-04 9.281564e-11 1.646563e-09 2 218264143 218264150 8 - 1.144 1.652 1.761
ENSG00000127837 E005 51.78139 4.602364e-04 2.375813e-12 5.482224e-11 2 218264151 218264161 11 - 1.194 1.711 1.786
ENSG00000127837 E006 235.80005 2.893807e-03 2.798225e-07 2.605630e-06 2 218264162 218264180 19 - 2.119 2.329 0.703
ENSG00000127837 E007 250.10208 2.358552e-03 8.041490e-09 1.008631e-07 2 218264181 218264182 2 - 2.134 2.356 0.745
ENSG00000127837 E008 1316.99509 4.046866e-03 5.510481e-03 1.731509e-02 2 218264183 218264359 177 - 2.959 3.055 0.320
ENSG00000127837 E009 3321.96829 7.682227e-04 7.341796e-06 5.029220e-05 2 218264360 218264608 249 - 3.381 3.451 0.234
ENSG00000127837 E010 3379.21884 3.012547e-04 3.042994e-07 2.812265e-06 2 218265020 218265174 155 - 3.397 3.456 0.195
ENSG00000127837 E011 1973.66285 2.006310e-04 1.893889e-03 6.894934e-03 2 218265371 218265416 46 - 3.179 3.218 0.129
ENSG00000127837 E012 1975.62254 2.010808e-04 2.995978e-05 1.783326e-04 2 218265417 218265461 45 - 3.169 3.221 0.171
ENSG00000127837 E013 45.96694 4.814881e-04 2.081018e-19 1.246026e-17 2 218265462 218265578 117 - 1.908 1.434 -1.611
ENSG00000127837 E014 1279.91500 8.830069e-04 2.072032e-03 7.447169e-03 2 218265579 218265580 2 - 2.974 3.036 0.206
ENSG00000127837 E015 2578.67400 5.649191e-05 1.563817e-06 1.245053e-05 2 218265581 218265682 102 - 3.290 3.335 0.149
ENSG00000127837 E016 94.55086 3.219562e-03 1.953021e-31 3.616754e-29 2 218265683 218265830 148 - 2.244 1.714 -1.781
ENSG00000127837 E017 2887.25622 5.956875e-04 1.342944e-01 2.401222e-01 2 218265831 218265946 116 - 3.357 3.381 0.079
ENSG00000127837 E018 39.96638 1.218322e-02 9.203913e-12 1.929247e-10 2 218265947 218266054 108 - 1.873 1.352 -1.778
ENSG00000127837 E019 28.84739 5.170849e-03 1.114224e-07 1.122263e-06 2 218266055 218266063 9 - 1.663 1.272 -1.345
ENSG00000127837 E020 1622.19872 3.724630e-04 6.238070e-01 7.402943e-01 2 218266064 218266086 23 - 3.118 3.127 0.032
ENSG00000127837 E021 2378.31376 1.063934e-04 8.598000e-01 9.135788e-01 2 218266087 218266147 61 - 3.287 3.291 0.013
ENSG00000127837 E022 87.41661 3.046889e-04 6.943219e-51 4.443824e-48 2 218266148 218266442 295 - 2.233 1.657 -1.935
ENSG00000127837 E023 3570.92524 6.326469e-05 4.575307e-08 4.972910e-07 2 218266443 218266587 145 - 3.497 3.458 -0.128
ENSG00000127837 E024 29.72746 6.798248e-04 7.786373e-17 3.393386e-15 2 218266588 218266844 257 - 1.758 1.226 -1.832
ENSG00000127837 E025 3099.59310 6.845279e-05 6.596494e-10 1.012383e-08 2 218266847 218266952 106 - 3.441 3.394 -0.157
ENSG00000127837 E026 1817.44990 9.592149e-04 4.392497e-05 2.509107e-04 2 218266953 218266986 34 - 3.226 3.159 -0.224
ENSG00000127837 E027 13.95861 2.407339e-02 3.284549e-04 1.494675e-03 2 218267380 218267493 114 - 1.381 0.969 -1.472
ENSG00000127837 E028 2857.86604 3.029349e-04 6.964290e-05 3.782688e-04 2 218267494 218267613 120 - 3.402 3.361 -0.134
ENSG00000127837 E029 3336.53946 7.737150e-04 1.141183e-02 3.214348e-02 2 218269382 218269534 153 - 3.464 3.431 -0.108
ENSG00000127837 E030 285.18329 1.743990e-04 7.057861e-04 2.919667e-03 2 218269535 218269537 3 - 2.432 2.351 -0.271
ENSG00000127837 E031 71.36427 2.208213e-03 3.233611e-02 7.650493e-02 2 218269538 218269658 121 - 1.853 1.745 -0.366
ENSG00000127837 E032 33.04770 1.150642e-02 3.139704e-01 4.566275e-01 2 218269659 218269740 82 - 1.505 1.426 -0.271
ENSG00000127837 E033 2335.63015 1.664219e-03 3.728163e-02 8.600279e-02 2 218269966 218270178 213 - 3.314 3.275 -0.131