ENSG00000127586

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000262315 ENSG00000127586 HEK293_OSMI2_2hA HEK293_TMG_2hB CHTF18 protein_coding protein_coding 48.89049 58.25295 34.03862 5.921989 1.439263 -0.7749824 14.529163 30.589873 5.413351 2.3914485 0.3346634 -2.4962691 0.28184583 0.52863333 0.1590000 -0.369633333 3.663072e-21 3.663072e-21 FALSE TRUE
ENST00000464728 ENSG00000127586 HEK293_OSMI2_2hA HEK293_TMG_2hB CHTF18 protein_coding retained_intron 48.89049 58.25295 34.03862 5.921989 1.439263 -0.7749824 5.864979 3.013961 5.067797 0.5369201 0.8036659 0.7477630 0.12147083 0.05103333 0.1475333 0.096500000 5.270579e-06 3.663072e-21 FALSE TRUE
ENST00000471202 ENSG00000127586 HEK293_OSMI2_2hA HEK293_TMG_2hB CHTF18 protein_coding retained_intron 48.89049 58.25295 34.03862 5.921989 1.439263 -0.7749824 3.119301 1.119196 3.754061 0.3239151 0.4486279 1.7369940 0.06771667 0.01910000 0.1117000 0.092600000 1.051736e-04 3.663072e-21 FALSE TRUE
ENST00000493715 ENSG00000127586 HEK293_OSMI2_2hA HEK293_TMG_2hB CHTF18 protein_coding processed_transcript 48.89049 58.25295 34.03862 5.921989 1.439263 -0.7749824 5.705001 6.911530 4.861291 1.6124511 0.4615778 -0.5067868 0.11782500 0.11613333 0.1433000 0.027166667 6.661070e-01 3.663072e-21 FALSE FALSE
ENST00000498439 ENSG00000127586 HEK293_OSMI2_2hA HEK293_TMG_2hB CHTF18 protein_coding retained_intron 48.89049 58.25295 34.03862 5.921989 1.439263 -0.7749824 6.187776 5.968707 3.674147 2.0239433 0.3154380 -0.6985029 0.12496667 0.10296667 0.1078000 0.004833333 8.899023e-01 3.663072e-21 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000127586 E001 0.0000000       16 788046 788062 17 +      
ENSG00000127586 E002 0.0000000       16 788063 788116 54 +      
ENSG00000127586 E003 1.0351233 0.0117918309 1.790011e-04 8.736629e-04 16 788165 788619 455 + 0.625 0.000 -14.037
ENSG00000127586 E004 0.1451727 0.0427958192 2.435698e-01   16 788620 788621 2 + 0.164 0.000 -13.633
ENSG00000127586 E005 0.1451727 0.0427958192 2.435698e-01   16 788622 788623 2 + 0.164 0.000 -13.633
ENSG00000127586 E006 0.1451727 0.0427958192 2.435698e-01   16 788624 788624 1 + 0.164 0.000 -13.633
ENSG00000127586 E007 4.6071717 0.0039254539 4.136522e-01 5.570956e-01 16 788625 788634 10 + 0.782 0.672 -0.450
ENSG00000127586 E008 14.5797153 0.0159663919 3.148638e-01 4.576197e-01 16 788635 788646 12 + 1.208 1.112 -0.345
ENSG00000127586 E009 32.3937657 0.0078505981 3.622855e-01 5.066765e-01 16 788647 788664 18 + 1.514 1.456 -0.200
ENSG00000127586 E010 146.2655456 0.0205987769 1.497893e-01 2.613934e-01 16 788665 788756 92 + 2.181 2.099 -0.276
ENSG00000127586 E011 112.3778722 0.0198761008 4.962212e-01 6.329202e-01 16 788757 788775 19 + 2.031 2.002 -0.096
ENSG00000127586 E012 7.4720987 0.0126108564 3.174946e-01 4.603851e-01 16 788928 788930 3 + 0.967 0.846 -0.456
ENSG00000127586 E013 227.5158957 0.0159240189 2.568737e-01 3.938916e-01 16 788931 789085 155 + 2.351 2.301 -0.170
ENSG00000127586 E014 130.4385333 0.0215703836 4.033377e-01 5.471107e-01 16 789086 789125 40 + 2.108 2.061 -0.157
ENSG00000127586 E015 8.8551429 0.0020315116 1.050567e-05 6.950470e-05 16 789126 789209 84 + 1.220 0.750 -1.756
ENSG00000127586 E016 100.4665299 0.0119284239 1.482329e-01 2.592792e-01 16 789210 789213 4 + 2.014 1.937 -0.257
ENSG00000127586 E017 98.3673195 0.0139504794 1.578261e-01 2.722299e-01 16 789214 789216 3 + 2.006 1.928 -0.263
ENSG00000127586 E018 197.4874554 0.0009796573 1.127401e-01 2.095449e-01 16 789217 789312 96 + 2.276 2.237 -0.128
ENSG00000127586 E019 112.4649517 0.0002901633 2.927709e-01 4.337711e-01 16 789313 789318 6 + 2.028 1.997 -0.101
ENSG00000127586 E020 157.5006372 0.0004489192 2.874662e-01 4.279633e-01 16 789319 789360 42 + 2.168 2.143 -0.084
ENSG00000127586 E021 0.4460135 0.0246106568 2.017897e-02 5.185841e-02 16 789361 789362 2 + 0.376 0.000 -15.352
ENSG00000127586 E022 2.1745274 0.0065891102 3.350780e-01 4.788356e-01 16 789363 789546 184 + 0.574 0.418 -0.769
ENSG00000127586 E023 105.5257815 0.0002978715 7.469125e-01 8.345689e-01 16 789547 789548 2 + 1.982 1.978 -0.015
ENSG00000127586 E024 181.2660227 0.0001980989 2.994446e-01 4.409415e-01 16 789549 789615 67 + 2.229 2.207 -0.073
ENSG00000127586 E025 219.3287565 0.0001860387 2.069836e-01 3.349141e-01 16 789616 789715 100 + 2.313 2.288 -0.084
ENSG00000127586 E026 4.5648665 0.1039031226 5.545833e-02 1.187729e-01 16 790007 790081 75 + 0.923 0.557 -1.499
ENSG00000127586 E027 5.4231034 0.0030676004 1.062728e-04 5.508210e-04 16 790082 790176 95 + 1.045 0.549 -1.990
ENSG00000127586 E028 169.3755522 0.0003439198 6.042119e-02 1.273346e-01 16 790177 790250 74 + 2.218 2.170 -0.161
ENSG00000127586 E029 115.9734095 0.0002478300 2.646743e-02 6.488321e-02 16 790251 790269 19 + 2.070 2.000 -0.235
ENSG00000127586 E030 3.8793126 0.0041717578 9.510617e-04 3.791418e-03 16 790331 790346 16 + 0.921 0.454 -1.991
ENSG00000127586 E031 169.1324822 0.0002022137 1.440576e-01 2.535283e-01 16 790347 790399 53 + 2.207 2.172 -0.118
ENSG00000127586 E032 117.0934027 0.0002978435 3.963720e-01 5.401410e-01 16 790525 790530 6 + 2.001 2.039 0.128
ENSG00000127586 E033 290.2519500 0.0004238663 3.263426e-01 4.697885e-01 16 790531 790666 136 + 2.429 2.414 -0.051
ENSG00000127586 E034 30.4954373 0.0007071748 1.733313e-32 3.500756e-30 16 790667 790671 5 + 1.833 1.074 -2.626
ENSG00000127586 E035 36.3678716 0.0309727983 1.357133e-11 2.766949e-10 16 790672 790698 27 + 1.883 1.199 -2.346
ENSG00000127586 E036 133.6733942 0.0046770047 3.916556e-44 1.717546e-41 16 790699 791136 438 + 2.418 1.797 -2.081
ENSG00000127586 E037 37.3356076 0.0015024626 7.773473e-23 6.780208e-21 16 791137 791160 24 + 1.853 1.274 -1.979
ENSG00000127586 E038 437.4161838 0.0001902930 4.467764e-01 5.882447e-01 16 791161 791370 210 + 2.601 2.594 -0.021
ENSG00000127586 E039 64.6247699 0.0003544879 2.046790e-50 1.275521e-47 16 791371 791457 87 + 2.121 1.468 -2.209
ENSG00000127586 E040 143.5271433 0.0016481122 6.708588e-62 7.304148e-59 16 791458 791850 393 + 2.431 1.855 -1.930
ENSG00000127586 E041 267.6626167 0.0002077857 4.132355e-01 5.567506e-01 16 791851 791948 98 + 2.364 2.392 0.092
ENSG00000127586 E042 91.2372150 0.0008708939 1.660582e-43 7.069491e-41 16 791949 792223 275 + 2.221 1.689 -1.789
ENSG00000127586 E043 287.8359445 0.0001875230 9.256219e-02 1.791251e-01 16 792224 792347 124 + 2.380 2.427 0.158
ENSG00000127586 E044 31.3551736 0.0006577531 2.915690e-05 1.740073e-04 16 792348 792367 20 + 1.626 1.369 -0.883
ENSG00000127586 E045 201.5416302 0.0008236332 5.437904e-04 2.323817e-03 16 792439 792523 85 + 2.178 2.293 0.386
ENSG00000127586 E046 180.2100870 0.0011537412 3.615635e-06 2.658430e-05 16 792524 792590 67 + 2.087 2.255 0.562
ENSG00000127586 E047 248.7559030 0.0019215150 6.599048e-04 2.751920e-03 16 792718 792811 94 + 2.265 2.386 0.404
ENSG00000127586 E048 1.4736456 0.1113331661 2.493524e-01 3.851629e-01 16 792812 792814 3 + 0.517 0.285 -1.308
ENSG00000127586 E049 145.9170737 0.0011656336 1.096941e-01 2.051108e-01 16 792966 792980 15 + 2.077 2.142 0.219
ENSG00000127586 E050 252.9206575 0.0001910542 2.005830e-04 9.663271e-04 16 792981 793064 84 + 2.284 2.386 0.339
ENSG00000127586 E051 312.5706098 0.0011168583 1.717841e-04 8.428028e-04 16 793144 793274 131 + 2.369 2.481 0.373
ENSG00000127586 E052 11.2329462 0.0041540855 3.747819e-06 2.746029e-05 16 793658 793802 145 + 1.317 0.859 -1.662
ENSG00000127586 E053 6.6647990 0.0045099016 4.310447e-09 5.679519e-08 16 794040 794053 14 + 1.208 0.489 -2.864
ENSG00000127586 E054 255.7353265 0.0033808252 5.570265e-03 1.747570e-02 16 794054 794141 88 + 2.284 2.397 0.377
ENSG00000127586 E055 224.0742284 0.0008519996 9.197589e-05 4.842845e-04 16 794142 794201 60 + 2.216 2.341 0.417
ENSG00000127586 E056 24.1992114 0.0008135638 2.016084e-17 9.461014e-16 16 794702 794844 143 + 1.680 1.090 -2.049
ENSG00000127586 E057 391.3047211 0.0001451367 2.073354e-14 6.512861e-13 16 795132 795356 225 + 2.422 2.589 0.557
ENSG00000127586 E058 414.6065300 0.0007685988 1.716976e-06 1.354865e-05 16 795685 795834 150 + 2.481 2.605 0.410
ENSG00000127586 E059 477.8915806 0.0029482777 5.438854e-06 3.840239e-05 16 795947 796077 131 + 2.517 2.678 0.537
ENSG00000127586 E060 18.6350985 0.0011671566 1.019257e-11 2.119130e-10 16 796615 796716 102 + 1.549 1.020 -1.863
ENSG00000127586 E061 493.0768716 0.0038201370 2.699087e-07 2.521246e-06 16 796717 796861 145 + 2.506 2.700 0.647
ENSG00000127586 E062 421.3823654 0.0050239431 1.929154e-07 1.854249e-06 16 796961 797092 132 + 2.417 2.638 0.738
ENSG00000127586 E063 316.8612730 0.0030805985 9.046179e-09 1.124227e-07 16 797694 797751 58 + 2.295 2.513 0.727
ENSG00000127586 E064 344.6090043 0.0028401270 1.430017e-04 7.165098e-04 16 797839 798040 202 + 2.392 2.533 0.470
ENSG00000127586 E065 48.8318049 0.0010487676 8.291388e-04 3.363191e-03 16 798041 798186 146 + 1.770 1.600 -0.576
ENSG00000127586 E066 26.7168071 0.0007238523 6.015004e-12 1.297716e-10 16 800687 800815 129 + 1.667 1.216 -1.555