ENSG00000127564

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000262300 ENSG00000127564 HEK293_OSMI2_2hA HEK293_TMG_2hB PKMYT1 protein_coding protein_coding 118.971 171.1042 86.56051 12.82502 2.092736 -0.9830119 57.916223 101.248939 40.375246 6.3981103 1.1396490 -1.32614903 0.46357083 0.59293333 0.46643333 -0.12650000 1.654906e-08 1.222923e-09 FALSE TRUE
ENST00000570649 ENSG00000127564 HEK293_OSMI2_2hA HEK293_TMG_2hB PKMYT1 protein_coding retained_intron 118.971 171.1042 86.56051 12.82502 2.092736 -0.9830119 8.966514 3.629876 8.254599 0.8408430 1.0791548 1.18305528 0.08791667 0.02086667 0.09503333 0.07416667 7.592706e-07 1.222923e-09 FALSE FALSE
ENST00000574680 ENSG00000127564 HEK293_OSMI2_2hA HEK293_TMG_2hB PKMYT1 protein_coding retained_intron 118.971 171.1042 86.56051 12.82502 2.092736 -0.9830119 13.701355 19.525449 8.638840 2.9116730 0.5034517 -1.17551584 0.11487083 0.11300000 0.09963333 -0.01336667 6.421518e-01 1.222923e-09 TRUE FALSE
ENST00000575632 ENSG00000127564 HEK293_OSMI2_2hA HEK293_TMG_2hB PKMYT1 protein_coding protein_coding 118.971 171.1042 86.56051 12.82502 2.092736 -0.9830119 7.563455 9.053636 8.595403 1.8941246 0.2237415 -0.07484713 0.06652917 0.05260000 0.09933333 0.04673333 1.776312e-02 1.222923e-09 FALSE FALSE
ENST00000575981 ENSG00000127564 HEK293_OSMI2_2hA HEK293_TMG_2hB PKMYT1 protein_coding retained_intron 118.971 171.1042 86.56051 12.82502 2.092736 -0.9830119 9.865860 9.505977 7.082837 0.4459788 0.4631368 -0.42398909 0.08760417 0.05580000 0.08206667 0.02626667 2.584049e-02 1.222923e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000127564 E001 7.7015810 0.0058435775 1.432967e-01 2.525056e-01 16 2968024 2968101 78 - 0.723 0.920 0.771
ENSG00000127564 E002 16.6618585 0.0010989167 6.366832e-01 7.506424e-01 16 2968102 2968352 251 - 1.218 1.166 -0.186
ENSG00000127564 E003 11.4541272 0.0015243211 8.661044e-01 9.177959e-01 16 2968353 2968515 163 - 1.048 1.021 -0.099
ENSG00000127564 E004 3.1407731 0.0050112137 9.726373e-01 9.869217e-01 16 2968908 2969104 197 - 0.565 0.553 -0.057
ENSG00000127564 E005 7.5615156 0.0307164313 2.699059e-01 4.084616e-01 16 2969888 2970241 354 - 0.723 0.893 0.671
ENSG00000127564 E006 0.4481018 0.1033966223 8.030537e-01 8.746169e-01 16 2971690 2972103 414 - 0.186 0.143 -0.454
ENSG00000127564 E007 0.8417882 0.0156761848 5.487248e-01 6.785539e-01 16 2972635 2972709 75 - 0.316 0.202 -0.850
ENSG00000127564 E008 0.6966155 0.0166756209 9.315893e-01 9.609064e-01 16 2972710 2972754 45 - 0.186 0.202 0.150
ENSG00000127564 E009 0.1482932 0.0415186030 1.000000e+00   16 2972755 2972790 36 - 0.000 0.078 8.286
ENSG00000127564 E010 1.0631447 0.0122075984 1.003580e-01 1.910211e-01 16 2972791 2972792 2 - 0.000 0.340 11.381
ENSG00000127564 E011 15.5875685 0.0012547374 1.757690e-02 4.621614e-02 16 2972793 2972807 15 - 0.956 1.200 0.886
ENSG00000127564 E012 15.7692729 0.0013235505 1.513958e-02 4.080103e-02 16 2972808 2972809 2 - 0.956 1.205 0.905
ENSG00000127564 E013 20.9547643 0.0025454163 6.376739e-03 1.960140e-02 16 2972810 2972812 3 - 1.068 1.322 0.900
ENSG00000127564 E014 51.6405623 0.0160274376 4.969678e-01 6.335353e-01 16 2972813 2972818 6 - 1.614 1.661 0.161
ENSG00000127564 E015 162.9775957 0.0038904244 6.639192e-01 7.718684e-01 16 2972819 2972848 30 - 2.163 2.136 -0.090
ENSG00000127564 E016 186.3209226 0.0029543481 3.112792e-01 4.537280e-01 16 2972849 2972850 2 - 2.236 2.189 -0.159
ENSG00000127564 E017 771.0523053 0.0022464719 2.580248e-01 3.952330e-01 16 2972851 2972994 144 - 2.796 2.821 0.082
ENSG00000127564 E018 800.0214721 0.0029047229 4.437906e-01 5.853732e-01 16 2972995 2973064 70 - 2.818 2.835 0.059
ENSG00000127564 E019 50.5322156 0.0005036438 4.985057e-03 1.588809e-02 16 2973065 2973137 73 - 1.753 1.593 -0.543
ENSG00000127564 E020 748.9221607 0.0009381339 1.001714e-01 1.907387e-01 16 2973138 2973215 78 - 2.780 2.807 0.092
ENSG00000127564 E021 71.3049487 0.0004053188 1.058100e-01 1.993257e-01 16 2973216 2973253 38 - 1.845 1.761 -0.287
ENSG00000127564 E022 96.7435848 0.0040348643 7.309133e-01 8.226930e-01 16 2973254 2973417 164 - 1.904 1.915 0.035
ENSG00000127564 E023 37.7563792 0.0067526365 3.827792e-01 5.269433e-01 16 2973418 2973445 28 - 1.460 1.521 0.211
ENSG00000127564 E024 103.5672871 0.0092543252 2.000786e-01 3.263572e-01 16 2973446 2973602 157 - 2.003 1.922 -0.271
ENSG00000127564 E025 835.0714180 0.0003057903 2.274021e-02 5.721430e-02 16 2974000 2974157 158 - 2.825 2.854 0.096
ENSG00000127564 E026 793.5995787 0.0001217153 1.160441e-09 1.698803e-08 16 2974245 2974417 173 - 2.756 2.841 0.283
ENSG00000127564 E027 620.1663788 0.0001074484 1.541809e-07 1.510296e-06 16 2974550 2974656 107 - 2.653 2.735 0.270
ENSG00000127564 E028 54.9819581 0.0004941158 3.665960e-12 8.192818e-11 16 2974657 2974795 139 - 1.913 1.561 -1.190
ENSG00000127564 E029 381.5546724 0.0001868817 1.172938e-04 6.014604e-04 16 2975319 2975339 21 - 2.448 2.524 0.254
ENSG00000127564 E030 1235.4780406 0.0001196975 7.544814e-10 1.145031e-08 16 2975340 2975652 313 - 2.962 3.030 0.226
ENSG00000127564 E031 461.5252031 0.0001633979 1.861667e-03 6.794467e-03 16 2975653 2975681 29 - 2.547 2.600 0.177
ENSG00000127564 E032 624.6081725 0.0001255736 3.747973e-02 8.636618e-02 16 2975682 2975748 67 - 2.698 2.725 0.087
ENSG00000127564 E033 631.5376495 0.0009573564 7.688500e-01 8.506124e-01 16 2975749 2975812 64 - 2.734 2.722 -0.041
ENSG00000127564 E034 9.7200195 0.0047177352 1.202593e-03 4.649448e-03 16 2975982 2976089 108 - 1.204 0.842 -1.335
ENSG00000127564 E035 915.7788079 0.0001467825 2.980829e-01 4.394760e-01 16 2976664 2976824 161 - 2.904 2.880 -0.078
ENSG00000127564 E036 740.7759660 0.0001200886 3.881876e-01 5.322961e-01 16 2976825 2976889 65 - 2.811 2.789 -0.073
ENSG00000127564 E037 972.6951471 0.0001011600 2.476867e-02 6.140052e-02 16 2976890 2977031 142 - 2.941 2.903 -0.128
ENSG00000127564 E038 62.3980311 0.0013133025 2.839968e-25 3.170439e-23 16 2977214 2977526 313 - 2.053 1.552 -1.692
ENSG00000127564 E039 12.6673435 0.0081226728 1.763742e-08 2.077958e-07 16 2979473 2979494 22 - 1.427 0.853 -2.067
ENSG00000127564 E040 33.8360448 0.0099003966 7.203718e-13 1.807340e-11 16 2979495 2979647 153 - 1.822 1.265 -1.906
ENSG00000127564 E041 833.8269016 0.0005818758 2.089702e-03 7.501427e-03 16 2979648 2979807 160 - 2.893 2.832 -0.205
ENSG00000127564 E042 377.2917362 0.0028211094 1.984629e-01 3.242929e-01 16 2979808 2979815 8 - 2.541 2.491 -0.164
ENSG00000127564 E043 707.4788275 0.0019386100 9.952952e-05 5.196662e-04 16 2979816 2979912 97 - 2.853 2.749 -0.344
ENSG00000127564 E044 46.5058970 0.0017660550 6.573350e-02 1.362623e-01 16 2979913 2979936 24 - 1.687 1.569 -0.401
ENSG00000127564 E045 8.1715028 0.0021355596 7.712033e-01 8.522853e-01 16 2980219 2980285 67 - 0.871 0.899 0.109
ENSG00000127564 E046 572.3136822 0.0051992652 4.496949e-04 1.965516e-03 16 2980286 2980479 194 - 2.784 2.649 -0.449