ENSG00000127511

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000248054 ENSG00000127511 HEK293_OSMI2_2hA HEK293_TMG_2hB SIN3B protein_coding protein_coding 36.70877 44.36162 29.87629 3.270445 0.2617988 -0.5701535 12.269278 14.946795 10.434766 1.9876323 0.3995051 -0.5180209 0.33238333 0.33436667 0.34946667 0.015100000 8.923345e-01 2.127204e-05 FALSE TRUE
ENST00000595049 ENSG00000127511 HEK293_OSMI2_2hA HEK293_TMG_2hB SIN3B protein_coding retained_intron 36.70877 44.36162 29.87629 3.270445 0.2617988 -0.5701535 4.820905 8.433607 1.563237 1.5166456 0.2248145 -2.4241231 0.11757083 0.18940000 0.05240000 -0.137000000 2.127204e-05 2.127204e-05 FALSE TRUE
ENST00000595900 ENSG00000127511 HEK293_OSMI2_2hA HEK293_TMG_2hB SIN3B protein_coding processed_transcript 36.70877 44.36162 29.87629 3.270445 0.2617988 -0.5701535 3.281059 3.232103 2.306702 0.7216845 0.3311483 -0.4848575 0.08887083 0.07126667 0.07700000 0.005733333 9.125533e-01 2.127204e-05 FALSE TRUE
ENST00000596802 ENSG00000127511 HEK293_OSMI2_2hA HEK293_TMG_2hB SIN3B protein_coding protein_coding 36.70877 44.36162 29.87629 3.270445 0.2617988 -0.5701535 8.630951 12.040753 7.269961 0.6716025 0.4809564 -0.7271206 0.24155417 0.27556667 0.24313333 -0.032433333 7.493857e-01 2.127204e-05 FALSE TRUE
ENST00000602204 ENSG00000127511 HEK293_OSMI2_2hA HEK293_TMG_2hB SIN3B protein_coding retained_intron 36.70877 44.36162 29.87629 3.270445 0.2617988 -0.5701535 1.992362 1.689305 2.110580 0.5219895 0.3863293 0.3195141 0.05559167 0.03693333 0.07086667 0.033933333 1.992317e-01 2.127204e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000127511 E001 0.6537541 0.4567625227 7.174747e-01 8.128419e-01 19 16829387 16829397 11 + 0.255 0.186 -0.580
ENSG00000127511 E002 1.0569037 0.2566454023 8.432046e-01 9.023475e-01 19 16829398 16829398 1 + 0.255 0.318 0.436
ENSG00000127511 E003 1.3472491 0.5470228844 8.600867e-01 9.137553e-01 19 16829399 16829401 3 + 0.413 0.321 -0.538
ENSG00000127511 E004 3.1885724 0.0458265331 3.248581e-02 7.677952e-02 19 16829402 16829406 5 + 0.792 0.456 -1.485
ENSG00000127511 E005 59.8069455 0.0430620976 4.674338e-02 1.033675e-01 19 16829407 16829540 134 + 1.865 1.697 -0.569
ENSG00000127511 E006 138.8608990 0.0093499535 1.951590e-02 5.044793e-02 19 16829791 16829897 107 + 2.184 2.091 -0.309
ENSG00000127511 E007 255.9126798 0.0033621905 2.484740e-03 8.718451e-03 19 16831494 16831647 154 + 2.434 2.363 -0.237
ENSG00000127511 E008 327.0678512 0.0012358871 1.191663e-02 3.333386e-02 19 16841768 16841951 184 + 2.514 2.484 -0.100
ENSG00000127511 E009 161.9446318 0.0028049698 2.475130e-02 6.136550e-02 19 16841952 16841968 17 + 2.224 2.174 -0.169
ENSG00000127511 E010 287.2077717 0.0019003597 3.996580e-02 9.096851e-02 19 16846970 16847113 144 + 2.455 2.429 -0.084
ENSG00000127511 E011 224.0373740 0.0002599243 6.861067e-01 7.886926e-01 19 16851412 16851534 123 + 2.303 2.346 0.144
ENSG00000127511 E012 161.9406798 0.0051414823 3.025115e-01 4.443799e-01 19 16853069 16853158 90 + 2.139 2.219 0.267
ENSG00000127511 E013 171.9156092 0.0072932156 4.074472e-02 9.240508e-02 19 16854143 16854261 119 + 2.126 2.262 0.453
ENSG00000127511 E014 332.3479320 0.0129186546 2.012058e-02 5.173866e-02 19 16854262 16855114 853 + 2.387 2.557 0.568
ENSG00000127511 E015 145.4124393 0.0051608126 9.514603e-02 1.830966e-01 19 16855115 16855745 631 + 2.070 2.183 0.377
ENSG00000127511 E016 148.4486998 0.0003467173 8.715340e-04 3.514673e-03 19 16862352 16862559 208 + 2.194 2.126 -0.228
ENSG00000127511 E017 14.5368190 0.0049074615 3.295278e-05 1.940809e-04 19 16862884 16862979 96 + 1.370 1.021 -1.238
ENSG00000127511 E018 8.8122049 0.0019419895 4.550210e-03 1.468174e-02 19 16862980 16863096 117 + 1.128 0.850 -1.028
ENSG00000127511 E019 13.0168809 0.0013162640 2.262691e-11 4.449451e-10 19 16863097 16863273 177 + 1.412 0.817 -2.160
ENSG00000127511 E020 9.6818673 0.0063010272 4.288372e-11 8.047738e-10 19 16863274 16863362 89 + 1.331 0.621 -2.686
ENSG00000127511 E021 17.5468380 0.0011356582 5.071779e-11 9.414397e-10 19 16863363 16863679 317 + 1.503 1.000 -1.777
ENSG00000127511 E022 130.0911007 0.0021967188 3.186650e-04 1.455508e-03 19 16863680 16863796 117 + 2.158 2.055 -0.346
ENSG00000127511 E023 0.5169874 0.0205183232 8.791623e-01 9.263896e-01 19 16865122 16865409 288 + 0.146 0.184 0.402
ENSG00000127511 E024 49.5475570 0.0060945509 4.633408e-03 1.491234e-02 19 16865410 16865413 4 + 1.765 1.624 -0.480
ENSG00000127511 E025 208.8213199 0.0010480309 5.315543e-05 2.975559e-04 19 16865414 16865648 235 + 2.349 2.267 -0.274
ENSG00000127511 E026 185.9435474 0.0002225654 5.993615e-06 4.193494e-05 19 16866373 16866556 184 + 2.304 2.216 -0.294
ENSG00000127511 E027 160.4128683 0.0002738731 1.752929e-01 2.950521e-01 19 16869460 16869739 280 + 2.189 2.182 -0.023
ENSG00000127511 E028 102.5206673 0.0074286312 2.570134e-01 3.940534e-01 19 16869740 16869881 142 + 1.922 2.023 0.341
ENSG00000127511 E029 90.9219628 0.0040766887 4.700543e-01 6.092706e-01 19 16869882 16869968 87 + 1.889 1.961 0.242
ENSG00000127511 E030 112.7006884 0.0016278480 3.285913e-01 4.720954e-01 19 16869969 16870075 107 + 1.982 2.055 0.245
ENSG00000127511 E031 150.8880358 0.0003128858 1.192409e-01 2.188598e-01 19 16871229 16871398 170 + 2.103 2.184 0.271
ENSG00000127511 E032 19.2076863 0.0248515947 3.984912e-03 1.310050e-02 19 16871399 16871638 240 + 1.438 1.159 -0.975
ENSG00000127511 E033 23.4193402 0.0019791261 1.114712e-01 2.077081e-01 19 16872468 16872666 199 + 1.412 1.325 -0.301
ENSG00000127511 E034 29.2596129 0.0006763565 2.958942e-01 4.370369e-01 19 16875931 16876054 124 + 1.391 1.494 0.352
ENSG00000127511 E035 174.8264945 0.0002552362 1.547958e-01 2.681345e-01 19 16876055 16876228 174 + 2.170 2.244 0.246
ENSG00000127511 E036 125.3207474 0.0014520301 2.173230e-01 3.471637e-01 19 16876486 16876578 93 + 2.022 2.102 0.270
ENSG00000127511 E037 11.0853531 0.0015904147 6.741345e-10 1.032523e-08 19 16876939 16877161 223 + 1.347 0.761 -2.156
ENSG00000127511 E038 11.9488068 0.0014180905 7.547124e-06 5.155519e-05 19 16877162 16877335 174 + 1.306 0.911 -1.428
ENSG00000127511 E039 12.9272043 0.0017045364 1.163474e-01 2.147411e-01 19 16877336 16877544 209 + 1.199 1.083 -0.415
ENSG00000127511 E040 112.5962418 0.0002983482 2.409018e-02 5.999727e-02 19 16877545 16877639 95 + 1.954 2.067 0.380
ENSG00000127511 E041 210.4903794 0.0033817402 2.141684e-01 3.434478e-01 19 16878183 16878390 208 + 2.245 2.329 0.279
ENSG00000127511 E042 1133.6831684 0.0059611271 5.014801e-05 2.825899e-04 19 16878497 16880353 1857 + 2.914 3.088 0.579