ENSG00000127483

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000312239 ENSG00000127483 HEK293_OSMI2_2hA HEK293_TMG_2hB HP1BP3 protein_coding protein_coding 59.61643 36.02 87.71364 0.6754332 1.904128 1.283767 17.015770 21.216298 21.228885 1.44527565 1.4463903 0.0008552869 0.32775000 0.58910000 0.24246667 -0.34663333 7.681061e-09 3.910351e-17 FALSE TRUE
ENST00000375003 ENSG00000127483 HEK293_OSMI2_2hA HEK293_TMG_2hB HP1BP3 protein_coding protein_coding 59.61643 36.02 87.71364 0.6754332 1.904128 1.283767 7.527612 3.173592 7.759466 0.04284119 0.2411639 1.2871602531 0.13160417 0.08810000 0.08860000 0.00050000 1.000000e+00 3.910351e-17 FALSE TRUE
ENST00000424732 ENSG00000127483 HEK293_OSMI2_2hA HEK293_TMG_2hB HP1BP3 protein_coding protein_coding 59.61643 36.02 87.71364 0.6754332 1.904128 1.283767 8.621472 2.516941 19.829763 0.25949011 1.1719896 2.9729311036 0.12358750 0.06973333 0.22573333 0.15600000 3.910351e-17 3.910351e-17 FALSE TRUE
ENST00000487117 ENSG00000127483 HEK293_OSMI2_2hA HEK293_TMG_2hB HP1BP3 protein_coding processed_transcript 59.61643 36.02 87.71364 0.6754332 1.904128 1.283767 4.592981 1.147015 5.252625 0.24870251 0.6009066 2.1853754951 0.07425000 0.03166667 0.05993333 0.02826667 8.820285e-02 3.910351e-17 FALSE TRUE
ENST00000488722 ENSG00000127483 HEK293_OSMI2_2hA HEK293_TMG_2hB HP1BP3 protein_coding processed_transcript 59.61643 36.02 87.71364 0.6754332 1.904128 1.283767 4.932211 0.000000 8.903491 0.00000000 1.9970127 9.7998466937 0.06569167 0.00000000 0.10173333 0.10173333 5.949288e-17 3.910351e-17 TRUE TRUE
MSTRG.478.3 ENSG00000127483 HEK293_OSMI2_2hA HEK293_TMG_2hB HP1BP3 protein_coding   59.61643 36.02 87.71364 0.6754332 1.904128 1.283767 4.849980 2.904637 5.067866 0.93080839 0.7018198 0.8009062827 0.08409167 0.08006667 0.05750000 -0.02256667 7.420709e-01 3.910351e-17 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000127483 E001 16.7334059 0.0010612765 8.455186e-01 9.039328e-01 1 20740266 20742678 2413 - 1.225 1.263 0.133
ENSG00000127483 E002 2.6537737 0.0061897330 9.916716e-04 3.929743e-03 1 20742679 20742681 3 - 0.244 0.812 2.866
ENSG00000127483 E003 40.1000306 0.0005163020 2.783960e-18 1.450132e-16 1 20742682 20742730 49 - 1.291 1.847 1.900
ENSG00000127483 E004 296.3799174 0.0043393247 4.539762e-30 7.692703e-28 1 20742731 20742941 211 - 2.191 2.690 1.665
ENSG00000127483 E005 160.8094640 0.0030739533 1.491993e-23 1.404839e-21 1 20742942 20742943 2 - 1.959 2.412 1.515
ENSG00000127483 E006 239.2553560 0.0068059686 1.343818e-23 1.272275e-21 1 20742944 20742988 45 - 2.073 2.607 1.781
ENSG00000127483 E007 166.0581808 0.0082328872 9.470266e-17 4.091479e-15 1 20742989 20742989 1 - 1.937 2.441 1.685
ENSG00000127483 E008 339.3792311 0.0038071297 1.303190e-37 3.858212e-35 1 20742990 20743134 145 - 2.234 2.755 1.739
ENSG00000127483 E009 173.6692647 0.0002873131 1.872953e-56 1.650350e-53 1 20743135 20743174 40 - 1.955 2.461 1.691
ENSG00000127483 E010 1468.9194501 0.0012433119 1.345193e-26 1.678807e-24 1 20743175 20744625 1451 - 3.046 3.285 0.794
ENSG00000127483 E011 245.4759764 0.0036920175 3.090088e-01 4.512963e-01 1 20744626 20744743 118 - 2.346 2.439 0.310
ENSG00000127483 E012 510.1306396 0.0003414670 5.117868e-01 6.467344e-01 1 20744744 20745091 348 - 2.673 2.741 0.226
ENSG00000127483 E013 217.5859947 0.0106046668 3.847221e-01 5.288668e-01 1 20745543 20745591 49 - 2.289 2.388 0.333
ENSG00000127483 E014 254.6136236 0.0054835778 9.150409e-01 9.502098e-01 1 20745592 20745656 65 - 2.377 2.434 0.191
ENSG00000127483 E015 225.5864943 0.0016396369 5.769708e-01 7.023195e-01 1 20747544 20747614 71 - 2.333 2.371 0.127
ENSG00000127483 E016 176.5059566 0.0002425905 4.710728e-01 6.102233e-01 1 20747615 20747655 41 - 2.229 2.266 0.125
ENSG00000127483 E017 308.8339563 0.0002013067 1.151505e-01 2.130654e-01 1 20749723 20749882 160 - 2.476 2.500 0.080
ENSG00000127483 E018 10.4227429 0.0017905320 4.299642e-01 5.725975e-01 1 20749883 20749975 93 - 0.990 1.122 0.482
ENSG00000127483 E019 2.1485177 0.1026022659 6.609866e-01 7.695622e-01 1 20749976 20750251 276 - 0.440 0.590 0.718
ENSG00000127483 E020 60.9236473 0.0030313754 6.097593e-03 1.886671e-02 1 20755045 20755238 194 - 1.821 1.734 -0.294
ENSG00000127483 E021 58.1081212 0.0115009673 4.153648e-02 9.388040e-02 1 20755239 20755404 166 - 1.799 1.718 -0.271
ENSG00000127483 E022 211.0804060 0.0005404154 3.250729e-07 2.985316e-06 1 20757166 20757198 33 - 2.355 2.274 -0.270
ENSG00000127483 E023 253.0996522 0.0008945455 5.979383e-07 5.209604e-06 1 20757199 20757256 58 - 2.432 2.356 -0.254
ENSG00000127483 E024 362.0723446 0.0003914099 2.450985e-09 3.380154e-08 1 20765377 20765526 150 - 2.582 2.514 -0.226
ENSG00000127483 E025 143.4925951 0.0009255483 3.183653e-05 1.882321e-04 1 20765527 20765531 5 - 2.187 2.105 -0.276
ENSG00000127483 E026 267.1219307 0.0001481992 5.378788e-07 4.728077e-06 1 20767584 20767664 81 - 2.445 2.390 -0.184
ENSG00000127483 E027 357.4382170 0.0001308020 1.791735e-11 3.575298e-10 1 20770930 20771073 144 - 2.578 2.504 -0.246
ENSG00000127483 E028 371.6501180 0.0001599025 1.978311e-17 9.299876e-16 1 20773451 20773586 136 - 2.607 2.499 -0.360
ENSG00000127483 E029 180.3816944 0.0002932008 1.958611e-11 3.887000e-10 1 20773587 20773610 24 - 2.304 2.173 -0.439
ENSG00000127483 E030 177.1649722 0.0002360190 3.513131e-15 1.236396e-13 1 20773611 20775005 1395 - 2.307 2.141 -0.554
ENSG00000127483 E031 20.6959099 0.0008984399 1.788114e-02 4.688230e-02 1 20775450 20775654 205 - 1.381 1.253 -0.449
ENSG00000127483 E032 15.3813699 0.0012025626 4.798928e-03 1.537142e-02 1 20775655 20775723 69 - 1.280 1.079 -0.717
ENSG00000127483 E033 53.0520446 0.0004411133 3.778971e-05 2.191688e-04 1 20775724 20776005 282 - 1.783 1.632 -0.513
ENSG00000127483 E034 59.8054047 0.0278656336 1.568719e-05 9.967437e-05 1 20776006 20776596 591 - 1.894 1.523 -1.258
ENSG00000127483 E035 350.6654641 0.0003807362 1.296055e-31 2.421438e-29 1 20776597 20776697 101 - 2.612 2.414 -0.658
ENSG00000127483 E036 220.2239730 0.0008921124 7.375164e-29 1.124962e-26 1 20776698 20776712 15 - 2.431 2.159 -0.908
ENSG00000127483 E037 181.1812957 0.0020711025 3.254356e-17 1.485252e-15 1 20776713 20776719 7 - 2.340 2.091 -0.831
ENSG00000127483 E038 243.0737910 0.0002528568 1.219232e-31 2.286930e-29 1 20776720 20776750 31 - 2.465 2.229 -0.786
ENSG00000127483 E039 213.7733383 0.0002058258 3.056215e-23 2.782271e-21 1 20779812 20779835 24 - 2.399 2.198 -0.672
ENSG00000127483 E040 276.8868416 0.0005522783 7.532391e-24 7.363204e-22 1 20779836 20779911 76 - 2.508 2.315 -0.647
ENSG00000127483 E041 90.5174459 0.0003075621 1.308319e-09 1.897834e-08 1 20780345 20780349 5 - 2.022 1.841 -0.608
ENSG00000127483 E042 204.8121380 0.0002371824 1.533147e-21 1.162265e-19 1 20780350 20780540 191 - 2.379 2.181 -0.659
ENSG00000127483 E043 0.4482035 0.0282168900 1.657583e-01 2.826907e-01 1 20780541 20780541 1 - 0.244 0.001 -9.063
ENSG00000127483 E044 31.9013800 0.0161306715 1.162316e-03 4.513348e-03 1 20786186 20786252 67 - 1.592 1.349 -0.834
ENSG00000127483 E045 64.7854780 0.0069448179 2.254800e-05 1.381294e-04 1 20786253 20786513 261 - 1.883 1.676 -0.702
ENSG00000127483 E046 26.8796619 0.0053637753 3.593478e-08 3.983695e-07 1 20786514 20786648 135 - 1.564 1.163 -1.395
ENSG00000127483 E047 28.7472820 0.0233175662 2.044823e-05 1.265552e-04 1 20786649 20786802 154 - 1.587 1.202 -1.334
ENSG00000127483 E048 64.0582821 0.0069201379 8.669279e-05 4.595839e-04 1 20787195 20787323 129 - 1.876 1.685 -0.644