ENSG00000127463

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000375199 ENSG00000127463 HEK293_OSMI2_2hA HEK293_TMG_2hB EMC1 protein_coding protein_coding 42.72815 34.57087 43.47758 1.699813 0.4634508 0.3306292 4.374258 2.231355 5.267980 0.4074369 0.4052276 1.2356143 0.09914167 0.06366667 0.1210000 0.05733333 1.314395e-02 1.341757e-10 FALSE TRUE
ENST00000375208 ENSG00000127463 HEK293_OSMI2_2hA HEK293_TMG_2hB EMC1 protein_coding protein_coding 42.72815 34.57087 43.47758 1.699813 0.4634508 0.3306292 14.684567 18.725112 11.031836 0.8063304 0.6843030 -0.7627645 0.35941667 0.54300000 0.2541333 -0.28886667 1.341757e-10 1.341757e-10 FALSE TRUE
ENST00000477853 ENSG00000127463 HEK293_OSMI2_2hA HEK293_TMG_2hB EMC1 protein_coding protein_coding 42.72815 34.57087 43.47758 1.699813 0.4634508 0.3306292 5.747926 5.621012 5.026168 1.1304826 0.6816030 -0.1610678 0.13858750 0.16650000 0.1158667 -0.05063333 6.376926e-01 1.341757e-10 FALSE TRUE
ENST00000486405 ENSG00000127463 HEK293_OSMI2_2hA HEK293_TMG_2hB EMC1 protein_coding protein_coding 42.72815 34.57087 43.47758 1.699813 0.4634508 0.3306292 10.764181 2.973865 14.010816 1.5248289 0.8081076 2.2323162 0.23710417 0.08193333 0.3220000 0.24006667 3.879537e-01 1.341757e-10 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000127463 E001 222.3521268 0.0236661987 3.653113e-01 5.096441e-01 1 19215660 19216804 1145 - 2.301 2.387 0.286
ENSG00000127463 E002 33.2680738 0.0006079195 2.611013e-01 3.987237e-01 1 19216805 19216873 69 - 1.569 1.498 -0.241
ENSG00000127463 E003 337.2117423 0.0023405584 6.143650e-09 7.888147e-08 1 19216874 19218147 1274 - 2.614 2.438 -0.587
ENSG00000127463 E004 454.1701457 0.0026049233 3.483365e-01 4.925643e-01 1 19218148 19218944 797 - 2.644 2.669 0.085
ENSG00000127463 E005 725.9588722 0.0025931136 1.460008e-16 6.158856e-15 1 19218945 19219302 358 - 2.729 2.952 0.741
ENSG00000127463 E006 468.3431541 0.0001964075 5.565987e-27 7.168318e-25 1 19219303 19219381 79 - 2.563 2.748 0.616
ENSG00000127463 E007 433.4305927 0.0001367805 4.113870e-19 2.371038e-17 1 19219382 19219482 101 - 2.547 2.702 0.515
ENSG00000127463 E008 286.8605883 0.0001967596 6.949517e-11 1.259509e-09 1 19219569 19219614 46 - 2.378 2.517 0.463
ENSG00000127463 E009 317.8789911 0.0005627933 6.973497e-07 5.990877e-06 1 19219615 19219669 55 - 2.440 2.550 0.366
ENSG00000127463 E010 254.2921828 0.0008792404 4.318682e-03 1.403739e-02 1 19219670 19219698 29 - 2.366 2.438 0.241
ENSG00000127463 E011 15.3753824 0.0011258342 4.859576e-01 6.237810e-01 1 19219699 19220763 1065 - 1.249 1.188 -0.218
ENSG00000127463 E012 300.0432780 0.0010117842 4.164971e-03 1.360557e-02 1 19220764 19220810 47 - 2.438 2.508 0.233
ENSG00000127463 E013 262.5240507 0.0002180035 7.515659e-03 2.255376e-02 1 19220811 19220848 38 - 2.388 2.446 0.192
ENSG00000127463 E014 31.0315229 0.0006657547 4.719400e-01 6.110249e-01 1 19220849 19221868 1020 - 1.483 1.525 0.145
ENSG00000127463 E015 24.1144872 0.0008584185 5.288280e-02 1.142815e-01 1 19221869 19222623 755 - 1.469 1.331 -0.477
ENSG00000127463 E016 439.9841751 0.0001796377 4.405321e-04 1.930054e-03 1 19222624 19222834 211 - 2.612 2.671 0.197
ENSG00000127463 E017 22.5272924 0.0019566638 1.769019e-06 1.392047e-05 1 19222835 19223395 561 - 1.526 1.158 -1.281
ENSG00000127463 E018 352.9514890 0.0001583292 1.221219e-05 7.951404e-05 1 19223396 19223569 174 - 2.503 2.585 0.273
ENSG00000127463 E019 320.9713029 0.0011980439 7.058033e-01 8.041024e-01 1 19227313 19227450 138 - 2.502 2.509 0.023
ENSG00000127463 E020 2.8637811 0.0056988223 1.823752e-01 3.041973e-01 1 19227451 19228190 740 - 0.462 0.671 0.959
ENSG00000127463 E021 0.6976476 0.0860373376 9.341204e-01 9.624910e-01 1 19229355 19229554 200 - 0.213 0.224 0.094
ENSG00000127463 E022 290.2295164 0.0007254526 9.085827e-01 9.459052e-01 1 19230844 19230963 120 - 2.465 2.459 -0.020
ENSG00000127463 E023 4.1609242 0.0313156111 1.619200e-01 2.776318e-01 1 19230964 19231260 297 - 0.825 0.602 -0.923
ENSG00000127463 E024 303.2829208 0.0005466850 5.572871e-01 6.857258e-01 1 19231261 19231422 162 - 2.475 2.485 0.035
ENSG00000127463 E025 5.6237368 0.0034217787 4.606846e-02 1.021600e-01 1 19231423 19232316 894 - 0.934 0.671 -1.041
ENSG00000127463 E026 284.8799480 0.0003916304 7.105554e-01 8.077029e-01 1 19232624 19232773 150 - 2.451 2.457 0.018
ENSG00000127463 E027 320.9067732 0.0014070797 6.483306e-01 7.598490e-01 1 19232936 19233135 200 - 2.515 2.500 -0.050
ENSG00000127463 E028 2.0120693 0.0637273539 4.185159e-03 1.366416e-02 1 19234180 19234188 9 - 0.681 0.126 -3.497
ENSG00000127463 E029 0.2987644 0.0270525751 2.190827e-01   1 19234189 19234308 120 - 0.213 0.000 -10.691
ENSG00000127463 E030 234.7979739 0.0018160267 9.488335e-02 1.827081e-01 1 19235130 19235252 123 - 2.399 2.344 -0.183
ENSG00000127463 E031 243.4118157 0.0050092054 2.377494e-02 5.935339e-02 1 19237142 19237238 97 - 2.434 2.339 -0.317
ENSG00000127463 E032 255.1347961 0.0023164237 4.591789e-04 2.003145e-03 1 19238017 19238139 123 - 2.464 2.350 -0.382
ENSG00000127463 E033 161.2865053 0.0015763692 7.292999e-04 3.004342e-03 1 19238795 19238854 60 - 2.267 2.151 -0.389
ENSG00000127463 E034 85.1519522 0.0046215449 1.458533e-02 3.955831e-02 1 19238855 19238857 3 - 1.997 1.872 -0.422
ENSG00000127463 E035 171.3977618 0.0055618233 4.776226e-02 1.051970e-01 1 19239231 19239302 72 - 2.281 2.190 -0.307
ENSG00000127463 E036 9.5226187 0.0018355536 1.864304e-03 6.803175e-03 1 19239303 19239668 366 - 1.164 0.826 -1.254
ENSG00000127463 E037 9.3485933 0.0095738361 1.175939e-05 7.687834e-05 1 19239669 19239817 149 - 1.209 0.672 -2.035
ENSG00000127463 E038 257.5774458 0.0038123983 2.759754e-02 6.720702e-02 1 19239818 19239985 168 - 2.454 2.369 -0.281
ENSG00000127463 E039 241.4424753 0.0003003199 2.371732e-05 1.446239e-04 1 19240297 19240446 150 - 2.434 2.331 -0.346
ENSG00000127463 E040 0.3697384 0.0248328891 1.822261e-01 3.039888e-01 1 19240447 19240568 122 - 0.000 0.223 10.584
ENSG00000127463 E041 189.9885775 0.0001860296 3.473463e-06 2.564533e-05 1 19241016 19241095 80 - 2.341 2.218 -0.412
ENSG00000127463 E042 141.4582401 0.0002366763 6.512936e-06 4.517634e-05 1 19241096 19241136 41 - 2.220 2.081 -0.464
ENSG00000127463 E043 114.1318533 0.0002724007 2.840058e-03 9.794664e-03 1 19241137 19241142 6 - 2.112 2.009 -0.343
ENSG00000127463 E044 0.9222279 0.0133388148 9.406287e-01 9.666876e-01 1 19241511 19242344 834 - 0.290 0.302 0.082
ENSG00000127463 E045 169.0779543 0.0016454624 1.420501e-04 7.123638e-04 1 19242345 19242385 41 - 2.292 2.162 -0.435
ENSG00000127463 E046 202.9744698 0.0011160556 1.214415e-04 6.204788e-04 1 19242386 19242473 88 - 2.364 2.248 -0.387
ENSG00000127463 E047 1.9468518 0.0086847653 3.145047e-01 4.572185e-01 1 19243418 19243515 98 - 0.355 0.525 0.894
ENSG00000127463 E048 115.7499209 0.0002813955 7.034591e-05 3.817781e-04 1 19243614 19243619 6 - 2.130 1.995 -0.454
ENSG00000127463 E049 237.4014353 0.0024909822 2.175979e-10 3.619251e-09 1 19243620 19243707 88 - 2.476 2.261 -0.719
ENSG00000127463 E050 1.8143686 0.0076396099 1.005503e-01 1.912892e-01 1 19243708 19243949 242 - 0.585 0.302 -1.502
ENSG00000127463 E051 206.0508811 0.0042644919 4.941124e-08 5.332884e-07 1 19243950 19244015 66 - 2.418 2.194 -0.747
ENSG00000127463 E052 1.7746132 0.0079451826 4.285651e-01 5.713045e-01 1 19244016 19244738 723 - 0.507 0.369 -0.723
ENSG00000127463 E053 0.9275265 0.0143815816 4.611341e-01 6.011179e-01 1 19244739 19244905 167 - 0.355 0.223 -0.917
ENSG00000127463 E054 236.8264414 0.0046085459 1.022193e-09 1.513730e-08 1 19244906 19245030 125 - 2.488 2.239 -0.832
ENSG00000127463 E055 148.4675360 0.0072559540 1.386199e-05 8.911135e-05 1 19251415 19251552 138 - 2.276 2.052 -0.749