ENSG00000127419

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000264771 ENSG00000127419 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM175 protein_coding protein_coding 28.2346 32.26489 23.43771 2.044281 1.298771 -0.4609653 5.710486 8.869963 2.1590186 0.6251841 1.19928852 -2.03351115 0.18971667 0.27913333 0.08853333 -0.190600000 0.4600572007 0.0002238606 FALSE TRUE
ENST00000452360 ENSG00000127419 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM175 protein_coding retained_intron 28.2346 32.26489 23.43771 2.044281 1.298771 -0.4609653 1.661809 1.412655 0.9768432 0.2542073 0.07903664 -0.52769253 0.05922917 0.04326667 0.04183333 -0.001433333 0.9812509819 0.0002238606 FALSE TRUE
ENST00000506669 ENSG00000127419 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM175 protein_coding retained_intron 28.2346 32.26489 23.43771 2.044281 1.298771 -0.4609653 1.981489 2.653773 2.7333930 0.4695074 1.02088516 0.04249028 0.06423333 0.08156667 0.11300000 0.031433333 0.7876865254 0.0002238606   FALSE
ENST00000508204 ENSG00000127419 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM175 protein_coding protein_coding 28.2346 32.26489 23.43771 2.044281 1.298771 -0.4609653 2.141197 4.003960 1.9782624 0.9161367 1.51233147 -1.01351802 0.07480417 0.12276667 0.08643333 -0.036333333 0.6566933611 0.0002238606 FALSE TRUE
ENST00000515876 ENSG00000127419 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM175 protein_coding retained_intron 28.2346 32.26489 23.43771 2.044281 1.298771 -0.4609653 3.417648 1.915958 5.3306207 0.3681205 0.54363543 1.47143123 0.13540417 0.06133333 0.22906667 0.167733333 0.0002238606 0.0002238606 FALSE TRUE
MSTRG.24429.1 ENSG00000127419 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM175 protein_coding   28.2346 32.26489 23.43771 2.044281 1.298771 -0.4609653 2.711492 5.408844 2.0627984 1.5438865 0.40345548 -1.38640536 0.09654167 0.16360000 0.09036667 -0.073233333 0.4658207600 0.0002238606 FALSE TRUE
MSTRG.24429.16 ENSG00000127419 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM175 protein_coding   28.2346 32.26489 23.43771 2.044281 1.298771 -0.4609653 2.920087 2.617457 2.4790700 1.3241020 0.53928891 -0.07806013 0.10079583 0.08146667 0.10460000 0.023133333 0.8274438645 0.0002238606 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000127419 E001 0.8449217 0.1080824992 4.757533e-01 6.144339e-01 4 932387 932403 17 + 0.155 0.298 1.207
ENSG00000127419 E002 2.2391848 0.0075723869 6.805199e-01 7.843907e-01 4 932404 932425 22 + 0.433 0.509 0.382
ENSG00000127419 E003 3.7431462 0.0138704171 9.908046e-01 9.984253e-01 4 932426 932431 6 + 0.646 0.651 0.021
ENSG00000127419 E004 4.5578790 0.0305948747 9.227768e-01 9.553118e-01 4 932432 932443 12 + 0.723 0.718 -0.020
ENSG00000127419 E005 4.5578790 0.0305948747 9.227768e-01 9.553118e-01 4 932444 932445 2 + 0.723 0.718 -0.020
ENSG00000127419 E006 8.3043506 0.0610201397 2.787972e-01 4.184641e-01 4 932446 932459 14 + 1.035 0.888 -0.546
ENSG00000127419 E007 8.4526438 0.0516003343 3.075321e-01 4.497706e-01 4 932460 932460 1 + 1.035 0.901 -0.498
ENSG00000127419 E008 8.4526438 0.0516003343 3.075321e-01 4.497706e-01 4 932461 932461 1 + 1.035 0.901 -0.498
ENSG00000127419 E009 10.5133334 0.0246870181 2.635493e-01 4.014695e-01 4 932462 932464 3 + 1.113 0.987 -0.459
ENSG00000127419 E010 15.6946482 0.0167236899 5.475398e-01 6.775826e-01 4 932465 932471 7 + 1.226 1.175 -0.182
ENSG00000127419 E011 17.1809912 0.0021323798 5.483234e-01 6.781847e-01 4 932472 932473 2 + 1.258 1.214 -0.156
ENSG00000127419 E012 24.3227765 0.0009149661 5.615185e-01 6.893113e-01 4 932474 932474 1 + 1.397 1.362 -0.120
ENSG00000127419 E013 31.1700398 0.0006833736 3.268263e-01 4.702703e-01 4 932475 932477 3 + 1.514 1.458 -0.191
ENSG00000127419 E014 35.3761408 0.0006851564 9.102286e-02 1.767528e-01 4 932478 932479 2 + 1.592 1.498 -0.322
ENSG00000127419 E015 40.7559944 0.0005705527 5.763801e-01 7.018207e-01 4 932480 932481 2 + 1.606 1.581 -0.083
ENSG00000127419 E016 48.7343499 0.0004882865 5.643526e-01 6.916502e-01 4 932482 932486 5 + 1.637 1.675 0.129
ENSG00000127419 E017 79.5431307 0.0057619985 8.101483e-01 8.795116e-01 4 932487 932516 30 + 1.875 1.872 -0.010
ENSG00000127419 E018 85.9928221 0.0058627245 3.415450e-01 4.854465e-01 4 932517 932540 24 + 1.933 1.893 -0.135
ENSG00000127419 E019 0.2214452 0.0383215929 8.177661e-01   4 945999 946126 128 + 0.000 0.096 8.177
ENSG00000127419 E020 127.9515538 0.0033125215 1.577366e-01 2.721014e-01 4 947709 947892 184 + 2.112 2.063 -0.164
ENSG00000127419 E021 15.6743597 0.0011411442 2.858365e-04 1.322301e-03 4 947893 948115 223 + 1.374 1.075 -1.058
ENSG00000127419 E022 86.9451937 0.0004423830 3.450537e-01 4.891380e-01 4 948116 948154 39 + 1.933 1.903 -0.100
ENSG00000127419 E023 12.3467624 0.0029611383 1.291136e-01 2.329387e-01 4 948155 948410 256 + 1.179 1.038 -0.509
ENSG00000127419 E024 12.9713281 0.0246729750 6.707854e-01 7.771500e-01 4 948411 948510 100 + 1.127 1.092 -0.126
ENSG00000127419 E025 13.0454015 0.0380794856 2.638431e-01 4.017577e-01 4 948511 948615 105 + 1.191 1.066 -0.451
ENSG00000127419 E026 80.7600413 0.0004149352 9.328923e-02 1.802669e-01 4 950421 950423 3 + 1.918 1.857 -0.205
ENSG00000127419 E027 101.7907813 0.0003979254 6.457691e-02 1.343381e-01 4 950424 950450 27 + 2.017 1.958 -0.201
ENSG00000127419 E028 132.6968861 0.0002450888 1.357814e-01 2.421913e-01 4 950451 950518 68 + 2.120 2.081 -0.133
ENSG00000127419 E029 131.2206574 0.0004620197 4.730255e-01 6.120455e-01 4 951207 951258 52 + 2.100 2.084 -0.053
ENSG00000127419 E030 0.8147328 0.1194013556 8.760146e-01 9.243811e-01 4 951259 951259 1 + 0.269 0.241 -0.212
ENSG00000127419 E031 12.4699523 0.0014464828 2.287473e-02 5.748252e-02 4 951646 951681 36 + 1.226 1.018 -0.750
ENSG00000127419 E032 121.4170360 0.0021488625 3.741136e-01 5.185296e-01 4 951682 951717 36 + 2.076 2.049 -0.089
ENSG00000127419 E033 3.5000081 0.0272027440 4.630475e-02 1.025820e-01 4 951718 951973 256 + 0.817 0.508 -1.321
ENSG00000127419 E034 87.7214449 0.0104575033 3.044733e-01 4.464723e-01 4 952367 952410 44 + 1.956 1.904 -0.175
ENSG00000127419 E035 74.7572941 0.0078711600 4.238491e-01 5.668734e-01 4 952411 952450 40 + 1.878 1.840 -0.126
ENSG00000127419 E036 210.5862068 0.0051940460 7.097367e-01 8.070306e-01 4 953190 953354 165 + 2.279 2.305 0.088
ENSG00000127419 E037 157.4959701 0.0019958882 2.759573e-01 4.153600e-01 4 955405 955483 79 + 2.134 2.183 0.162
ENSG00000127419 E038 4.4578212 0.0036480763 3.093783e-01 4.516653e-01 4 955484 955491 8 + 0.788 0.650 -0.565
ENSG00000127419 E039 207.8830336 0.0059524500 1.265858e-01 2.293940e-01 4 955755 955890 136 + 2.231 2.312 0.270
ENSG00000127419 E040 9.7137165 0.0017481584 8.282728e-02 1.639780e-01 4 955891 955944 54 + 1.113 0.938 -0.642
ENSG00000127419 E041 36.6220417 0.0008817219 3.339141e-01 4.776821e-01 4 956297 956892 596 + 1.572 1.521 -0.175
ENSG00000127419 E042 440.7461638 0.0011559168 3.218456e-12 7.269904e-11 4 957824 958656 833 + 2.495 2.660 0.550