ENSG00000127418

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000264748 ENSG00000127418 HEK293_OSMI2_2hA HEK293_TMG_2hB FGFRL1 protein_coding protein_coding 26.58619 35.3549 23.61623 2.545224 0.5172129 -0.5819286 24.0621193 33.35453 20.266190 2.707871 0.4168990 -0.7185285 0.90477083 0.9427 0.85816667 -0.08453333 6.164601e-02 1.97566e-22 FALSE  
ENST00000510644 ENSG00000127418 HEK293_OSMI2_2hA HEK293_TMG_2hB FGFRL1 protein_coding protein_coding 26.58619 35.3549 23.61623 2.545224 0.5172129 -0.5819286 0.6457472 0.00000 1.645942 0.000000 0.1823146 7.3715079 0.02436667 0.0000 0.06993333 0.06993333 1.975660e-22 1.97566e-22 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000127418 E001 0.6298062 0.020434037 5.808783e-01 7.055474e-01 4 1009936 1009978 43 + 0.140 0.263 1.125
ENSG00000127418 E002 1.7359034 0.008133366 2.838121e-01 4.239960e-01 4 1009979 1010169 191 + 0.517 0.378 -0.721
ENSG00000127418 E003 2.0961771 0.007917306 8.183658e-01 8.852096e-01 4 1010924 1010926 3 + 0.463 0.469 0.031
ENSG00000127418 E004 3.8728666 0.038983539 2.491679e-01 3.849342e-01 4 1010927 1011101 175 + 0.746 0.611 -0.571
ENSG00000127418 E005 1.9250844 0.012480648 1.176913e-02 3.298165e-02 4 1011102 1011296 195 + 0.647 0.263 -2.040
ENSG00000127418 E006 0.3030308 0.389133938 1.728884e-01   4 1011626 1011633 8 + 0.247 0.000 -20.293
ENSG00000127418 E007 1.4961260 0.377687595 5.317040e-03 1.679529e-02 4 1011634 1011694 61 + 0.685 0.000 -22.616
ENSG00000127418 E008 2.5949501 0.457592647 1.136470e-02 3.203643e-02 4 1011695 1011720 26 + 0.852 0.109 -4.417
ENSG00000127418 E009 3.6299597 0.004257354 2.275244e-09 3.156863e-08 4 1011721 1011816 96 + 0.990 0.106 -4.980
ENSG00000127418 E010 14.1739629 0.015649424 1.607308e-06 1.276407e-05 4 1011817 1011954 138 + 1.378 0.934 -1.592
ENSG00000127418 E011 1.2608349 0.010864776 4.354771e-03 1.413467e-02 4 1011955 1011987 33 + 0.565 0.107 -3.263
ENSG00000127418 E012 0.1482932 0.042471694 7.462538e-01   4 1012146 1012154 9 + 0.000 0.106 18.094
ENSG00000127418 E013 0.1482932 0.042471694 7.462538e-01   4 1012155 1012155 1 + 0.000 0.106 18.094
ENSG00000127418 E014 0.8083770 0.134054713 9.515472e-01 9.736759e-01 4 1012156 1012244 89 + 0.246 0.262 0.123
ENSG00000127418 E015 1.1801917 0.031867867 5.993209e-01 7.207495e-01 4 1012245 1012277 33 + 0.246 0.378 0.864
ENSG00000127418 E016 0.3030308 0.389133938 1.728884e-01   4 1012278 1012450 173 + 0.247 0.000 -20.293
ENSG00000127418 E017 0.4513240 0.233896752 3.923849e-01 5.363320e-01 4 1012451 1012469 19 + 0.247 0.105 -1.480
ENSG00000127418 E018 44.3728896 0.010743749 1.492909e-03 5.612986e-03 4 1012470 1012564 95 + 1.726 1.570 -0.533
ENSG00000127418 E019 215.8704038 0.009689168 9.396713e-02 1.813345e-01 4 1022203 1022475 273 + 2.323 2.318 -0.016
ENSG00000127418 E020 162.8108447 0.007242035 5.082904e-01 6.437416e-01 4 1023641 1023721 81 + 2.169 2.213 0.145
ENSG00000127418 E021 377.3928277 0.004028262 2.843197e-02 6.887988e-02 4 1023817 1024101 285 + 2.560 2.563 0.012
ENSG00000127418 E022 207.6522705 0.001506442 8.035580e-04 3.271850e-03 4 1024311 1024399 89 + 2.319 2.289 -0.099
ENSG00000127418 E023 299.2318888 0.002336990 1.134204e-01 2.105118e-01 4 1024400 1024664 265 + 2.445 2.471 0.086
ENSG00000127418 E024 1856.0623783 0.010248737 3.602418e-03 1.201738e-02 4 1024905 1026898 1994 + 3.164 3.302 0.456