ENSG00000126870

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000407559 ENSG00000126870 HEK293_OSMI2_2hA HEK293_TMG_2hB DYNC2I1 protein_coding protein_coding 6.21692 4.288502 6.989388 0.3496973 0.1517985 0.7033948 4.1266543 3.02890889 3.8906154 0.21815189 1.1174554 0.3601484 0.66330000 0.70760000 0.56190000 -0.14570000 7.392159e-01 3.000125e-12 FALSE TRUE
ENST00000444851 ENSG00000126870 HEK293_OSMI2_2hA HEK293_TMG_2hB DYNC2I1 protein_coding nonsense_mediated_decay 6.21692 4.288502 6.989388 0.3496973 0.1517985 0.7033948 0.2279369 0.59596122 0.0000000 0.07805797 0.0000000 -5.9211536 0.04924167 0.14160000 0.00000000 -0.14160000 3.000125e-12 3.000125e-12 TRUE TRUE
ENST00000454771 ENSG00000126870 HEK293_OSMI2_2hA HEK293_TMG_2hB DYNC2I1 protein_coding nonsense_mediated_decay 6.21692 4.288502 6.989388 0.3496973 0.1517985 0.7033948 0.1790697 0.27579217 0.0000000 0.27579217 0.0000000 -4.8368945 0.03455000 0.05533333 0.00000000 -0.05533333 7.063570e-01 3.000125e-12 TRUE TRUE
MSTRG.31006.1 ENSG00000126870 HEK293_OSMI2_2hA HEK293_TMG_2hB DYNC2I1 protein_coding   6.21692 4.288502 6.989388 0.3496973 0.1517985 0.7033948 0.3636553 0.07209748 0.7409976 0.07209748 0.7409976 3.1933983 0.05307083 0.01863333 0.10363333 0.08500000 9.905076e-01 3.000125e-12 TRUE TRUE
MSTRG.31006.2 ENSG00000126870 HEK293_OSMI2_2hA HEK293_TMG_2hB DYNC2I1 protein_coding   6.21692 4.288502 6.989388 0.3496973 0.1517985 0.7033948 0.4935574 0.10033490 0.8309343 0.03006377 0.1781429 2.9301038 0.07706667 0.02470000 0.11890000 0.09420000 7.418617e-03 3.000125e-12 TRUE TRUE
MSTRG.31006.4 ENSG00000126870 HEK293_OSMI2_2hA HEK293_TMG_2hB DYNC2I1 protein_coding   6.21692 4.288502 6.989388 0.3496973 0.1517985 0.7033948 0.2071804 0.08773167 0.5612371 0.08773167 0.5612371 2.5471916 0.03025417 0.02186667 0.07870000 0.05683333 9.693008e-01 3.000125e-12 TRUE TRUE
MSTRG.31006.6 ENSG00000126870 HEK293_OSMI2_2hA HEK293_TMG_2hB DYNC2I1 protein_coding   6.21692 4.288502 6.989388 0.3496973 0.1517985 0.7033948 0.1208616 0.00000000 0.5979588 0.00000000 0.5979588 5.9259015 0.01590417 0.00000000 0.08363333 0.08363333 9.100353e-01 3.000125e-12 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000126870 E001 0.1817044 0.0409110567 3.257228e-01   7 158856546 158856557 12 + 0.000 0.147 9.722
ENSG00000126870 E002 0.1817044 0.0409110567 3.257228e-01   7 158856558 158856565 8 + 0.000 0.147 9.735
ENSG00000126870 E003 0.7761102 0.0542288476 1.634102e-01 2.796049e-01 7 158856566 158856575 10 + 0.101 0.347 2.219
ENSG00000126870 E004 1.6619082 0.0108835263 5.325875e-01 6.649301e-01 7 158856576 158856600 25 + 0.453 0.345 -0.598
ENSG00000126870 E005 20.8975883 0.0167379619 4.600490e-01 6.001040e-01 7 158856601 158856750 150 + 1.362 1.294 -0.236
ENSG00000126870 E006 0.0000000       7 158869446 158869490 45 +      
ENSG00000126870 E007 20.8726002 0.0150207309 1.373002e-01 2.443138e-01 7 158869855 158869908 54 + 1.391 1.255 -0.475
ENSG00000126870 E008 67.4890674 0.0013420427 2.018206e-04 9.716718e-04 7 158871142 158871562 421 + 1.897 1.732 -0.558
ENSG00000126870 E009 26.2271946 0.0007487489 1.069112e-04 5.539046e-04 7 158876609 158876691 83 + 1.532 1.264 -0.929
ENSG00000126870 E010 29.4616307 0.0007811495 1.678991e-06 1.327767e-05 7 158879684 158879779 96 + 1.594 1.273 -1.108
ENSG00000126870 E011 49.8541765 0.0004369673 2.107893e-05 1.300381e-04 7 158879780 158879989 210 + 1.784 1.572 -0.719
ENSG00000126870 E012 20.9066533 0.0009114152 3.706296e-01 5.150346e-01 7 158884564 158884573 10 + 1.362 1.301 -0.215
ENSG00000126870 E013 24.4930516 0.0007997972 3.434487e-01 4.874867e-01 7 158884574 158884619 46 + 1.427 1.366 -0.211
ENSG00000126870 E014 23.7506909 0.0009255774 4.679225e-01 6.073510e-01 7 158887021 158887075 55 + 1.405 1.358 -0.161
ENSG00000126870 E015 29.3752299 0.0051169240 1.823758e-02 4.764805e-02 7 158891265 158891333 69 + 1.542 1.374 -0.579
ENSG00000126870 E016 32.7926789 0.0007461475 4.816366e-04 2.089890e-03 7 158901739 158901816 78 + 1.609 1.395 -0.734
ENSG00000126870 E017 54.3587417 0.0004567183 2.614655e-02 6.424291e-02 7 158902376 158902595 220 + 1.784 1.683 -0.340
ENSG00000126870 E018 14.8078636 0.0011660678 7.738183e-02 1.552743e-01 7 158902596 158905283 2688 + 1.256 1.104 -0.542
ENSG00000126870 E019 35.5016637 0.0006193591 7.606229e-02 1.532140e-01 7 158905989 158906091 103 + 1.600 1.501 -0.339
ENSG00000126870 E020 38.5735995 0.0006017326 1.410795e-02 3.847175e-02 7 158911550 158911679 130 + 1.651 1.517 -0.458
ENSG00000126870 E021 42.3640308 0.0073669777 9.878319e-01 9.964559e-01 7 158912985 158913096 112 + 1.633 1.637 0.014
ENSG00000126870 E022 35.4507395 0.0006167704 4.415897e-01 5.832295e-01 7 158914233 158914321 89 + 1.535 1.586 0.173
ENSG00000126870 E023 51.9231321 0.0004978059 1.711029e-01 2.896105e-01 7 158918740 158918869 130 + 1.688 1.760 0.244
ENSG00000126870 E024 57.1787278 0.0004340292 3.525710e-01 4.968241e-01 7 158922377 158922549 173 + 1.741 1.789 0.165
ENSG00000126870 E025 57.1043276 0.0004250264 4.464803e-01 5.879589e-01 7 158923571 158923733 163 + 1.743 1.784 0.138
ENSG00000126870 E026 51.9728968 0.0004676665 7.972686e-01 8.706538e-01 7 158926187 158926300 114 + 1.722 1.715 -0.022
ENSG00000126870 E027 38.7242658 0.0006157037 5.029546e-01 6.389488e-01 7 158926402 158926463 62 + 1.574 1.617 0.148
ENSG00000126870 E028 42.9253492 0.0005419730 6.231599e-01 7.397996e-01 7 158926992 158927043 52 + 1.625 1.657 0.109
ENSG00000126870 E029 43.0709593 0.0005405616 1.704157e-01 2.887025e-01 7 158930455 158930515 61 + 1.609 1.687 0.266
ENSG00000126870 E030 39.0713151 0.0013460849 9.531345e-04 3.798722e-03 7 158934129 158934192 64 + 1.508 1.701 0.657
ENSG00000126870 E031 34.5564229 0.0007003702 2.129229e-03 7.625110e-03 7 158934193 158934228 36 + 1.459 1.645 0.636
ENSG00000126870 E032 51.0099489 0.0015009226 2.159449e-03 7.718744e-03 7 158934418 158934549 132 + 1.636 1.798 0.548
ENSG00000126870 E033 60.9857776 0.0008108188 9.928844e-03 2.858603e-02 7 158941925 158942148 224 + 1.732 1.855 0.415
ENSG00000126870 E034 59.0689573 0.0004756034 7.751196e-04 3.169662e-03 7 158945581 158945835 255 + 1.697 1.855 0.535
ENSG00000126870 E035 24.7311055 0.0208801291 6.366517e-07 5.515949e-06 7 158945836 158945936 101 + 1.117 1.611 1.722
ENSG00000126870 E036 31.9361046 0.0201985411 6.021175e-06 4.209512e-05 7 158945937 158946189 253 + 1.276 1.695 1.442
ENSG00000126870 E037 0.6696487 0.0279327541 5.475126e-01 6.775757e-01 7 158946446 158946634 189 + 0.252 0.148 -0.960
ENSG00000126870 E038 2.6216894 0.0058420870 5.233965e-02 1.133262e-01 7 158947070 158947173 104 + 0.669 0.345 -1.600
ENSG00000126870 E039 4.0565391 0.0742587488 2.226983e-01 3.535948e-01 7 158947174 158947364 191 + 0.795 0.577 -0.916
ENSG00000126870 E040 5.3020816 0.0625763794 9.769219e-01 9.895878e-01 7 158956583 158956747 165 + 0.797 0.796 -0.004