ENSG00000126822

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000247226 ENSG00000126822 HEK293_OSMI2_2hA HEK293_TMG_2hB PLEKHG3 protein_coding protein_coding 8.378496 10.95391 5.159725 0.8790878 0.1810045 -1.084603 0.5457182 0.5906711 0.2938356 0.05554744 0.01701255 -0.9832843 0.06699167 0.05383333 0.05733333 0.00350000 0.98492738 0.04686525 FALSE TRUE
ENST00000394691 ENSG00000126822 HEK293_OSMI2_2hA HEK293_TMG_2hB PLEKHG3 protein_coding protein_coding 8.378496 10.95391 5.159725 0.8790878 0.1810045 -1.084603 0.7005074 0.5668931 0.9906958 0.33052064 0.26761927 0.7946276 0.09009583 0.05103333 0.19483333 0.14380000 0.32597633 0.04686525 FALSE TRUE
ENST00000471182 ENSG00000126822 HEK293_OSMI2_2hA HEK293_TMG_2hB PLEKHG3 protein_coding protein_coding 8.378496 10.95391 5.159725 0.8790878 0.1810045 -1.084603 3.6587530 4.1663255 2.1482178 0.33887457 0.13610111 -0.9523937 0.44367917 0.38643333 0.41586667 0.02943333 0.86793725 0.04686525 FALSE TRUE
ENST00000484731 ENSG00000126822 HEK293_OSMI2_2hA HEK293_TMG_2hB PLEKHG3 protein_coding protein_coding 8.378496 10.95391 5.159725 0.8790878 0.1810045 -1.084603 1.3248280 3.4062575 0.1945409 0.66031635 0.19454088 -4.0619556 0.12631667 0.30856667 0.03686667 -0.27170000 0.04686525 0.04686525 FALSE TRUE
MSTRG.9701.3 ENSG00000126822 HEK293_OSMI2_2hA HEK293_TMG_2hB PLEKHG3 protein_coding   8.378496 10.95391 5.159725 0.8790878 0.1810045 -1.084603 0.8977440 1.2070222 0.7660835 0.13663808 0.12424655 -0.6490717 0.11044167 0.10970000 0.14980000 0.04010000 0.54842994 0.04686525 FALSE TRUE
MSTRG.9701.6 ENSG00000126822 HEK293_OSMI2_2hA HEK293_TMG_2hB PLEKHG3 protein_coding   8.378496 10.95391 5.159725 0.8790878 0.1810045 -1.084603 0.9413136 0.7857294 0.4611369 0.22239718 0.23205043 -0.7561316 0.12383750 0.07056667 0.08646667 0.01590000 0.98267157 0.04686525 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000126822 E001 0.1515154 0.0414847135 2.223579e-01   14 64704102 64704131 30 + 0.172 0.000 -10.830
ENSG00000126822 E002 1.2157810 0.0117396369 1.642268e-01 2.806674e-01 14 64704404 64704416 13 + 0.468 0.219 -1.561
ENSG00000126822 E003 1.2157810 0.0117396369 1.642268e-01 2.806674e-01 14 64704417 64704423 7 + 0.468 0.219 -1.561
ENSG00000126822 E004 1.5791897 0.0189874678 4.220200e-01 5.651795e-01 14 64704424 64704435 12 + 0.468 0.321 -0.822
ENSG00000126822 E005 6.8312346 0.2879897768 1.304855e-01 2.348368e-01 14 64704436 64704585 150 + 1.069 0.716 -1.352
ENSG00000126822 E006 23.0685450 0.0205501299 2.928421e-03 1.005369e-02 14 64704586 64704704 119 + 1.519 1.224 -1.025
ENSG00000126822 E007 0.0000000       14 64715703 64716092 390 +      
ENSG00000126822 E008 0.2214452 0.0369819639 1.000000e+00   14 64723781 64723914 134 + 0.000 0.086 11.008
ENSG00000126822 E009 63.6108206 0.0038134202 3.651109e-04 1.639158e-03 14 64727593 64727883 291 + 1.887 1.695 -0.650
ENSG00000126822 E010 39.0951602 0.0006459650 2.132859e-03 7.636159e-03 14 64727884 64727982 99 + 1.672 1.491 -0.620
ENSG00000126822 E011 30.2402380 0.0007096162 2.176865e-02 5.519650e-02 14 64728996 64729093 98 + 1.549 1.395 -0.530
ENSG00000126822 E012 23.6898176 0.0008475414 3.573816e-04 1.608749e-03 14 64730243 64730312 70 + 1.512 1.251 -0.904
ENSG00000126822 E013 16.4547312 0.0011500302 1.836666e-03 6.716809e-03 14 64730642 64730649 8 + 1.367 1.100 -0.944
ENSG00000126822 E014 21.4304823 0.0008965582 3.427191e-03 1.151648e-02 14 64730650 64730688 39 + 1.449 1.224 -0.786
ENSG00000126822 E015 44.0149881 0.0005557674 5.632771e-03 1.763821e-02 14 64730799 64730949 151 + 1.711 1.556 -0.528
ENSG00000126822 E016 53.4034999 0.0005191226 1.439482e-04 7.206787e-04 14 64731038 64731169 132 + 1.816 1.624 -0.650
ENSG00000126822 E017 66.1401897 0.0055683241 3.077776e-02 7.347972e-02 14 64731361 64731543 183 + 1.864 1.739 -0.424
ENSG00000126822 E018 1.4329743 0.0096215571 3.167593e-02 7.521444e-02 14 64731544 64731713 170 + 0.592 0.219 -2.149
ENSG00000126822 E019 52.5657051 0.0069548050 1.226385e-01 2.237196e-01 14 64731714 64731806 93 + 1.750 1.649 -0.342
ENSG00000126822 E020 63.4118324 0.0004330742 4.368007e-01 5.788333e-01 14 64732095 64732181 87 + 1.786 1.745 -0.137
ENSG00000126822 E021 43.8882244 0.0005102687 9.007322e-01 9.406852e-01 14 64732427 64732460 34 + 1.605 1.594 -0.037
ENSG00000126822 E022 67.1197622 0.0003608428 6.040204e-01 7.246707e-01 14 64732803 64732901 99 + 1.800 1.772 -0.093
ENSG00000126822 E023 51.2585477 0.0004857265 8.802458e-01 9.271909e-01 14 64736853 64736891 39 + 1.659 1.663 0.015
ENSG00000126822 E024 3.8226148 0.0044873679 6.172800e-01 7.351253e-01 14 64736892 64737355 464 + 0.688 0.609 -0.340
ENSG00000126822 E025 38.4146723 0.0104542959 9.154161e-01 9.504704e-01 14 64737356 64737375 20 + 1.543 1.535 -0.026
ENSG00000126822 E026 38.0539186 0.0006036734 5.802109e-01 7.049900e-01 14 64737862 64737990 129 + 1.512 1.543 0.106
ENSG00000126822 E027 20.9659956 0.0008983851 2.271947e-01 3.590609e-01 14 64737991 64738137 147 + 1.218 1.315 0.343
ENSG00000126822 E028 29.8039631 0.0007091075 9.457316e-02 1.822424e-01 14 64738138 64738224 87 + 1.349 1.465 0.403
ENSG00000126822 E029 59.0458952 0.0004504157 9.097686e-02 1.766790e-01 14 64738742 64738855 114 + 1.659 1.742 0.283
ENSG00000126822 E030 183.6310071 0.0002102096 3.943517e-01 5.382087e-01 14 64741036 64741595 560 + 2.196 2.216 0.068
ENSG00000126822 E031 95.4964041 0.0003409642 9.342917e-01 9.625709e-01 14 64741596 64741784 189 + 1.929 1.928 -0.001
ENSG00000126822 E032 226.1280981 0.0001778956 2.913424e-01 4.321987e-01 14 64741785 64742455 671 + 2.284 2.307 0.076
ENSG00000126822 E033 248.9977601 0.0002719681 4.483625e-05 2.555537e-04 14 64742982 64743655 674 + 2.270 2.368 0.328
ENSG00000126822 E034 182.5895819 0.0011240185 1.198510e-06 9.788927e-06 14 64743656 64744069 414 + 2.092 2.249 0.524
ENSG00000126822 E035 85.6261794 0.0003915296 1.610060e-07 1.572030e-06 14 64744070 64745079 1010 + 1.703 1.937 0.790
ENSG00000126822 E036 55.7276773 0.0004684069 6.295962e-01 7.449527e-01 14 64745080 64749044 3965 + 1.681 1.703 0.072
ENSG00000126822 E037 45.4906734 0.0039649517 2.726989e-01 4.116492e-01 14 64749045 64750249 1205 + 1.561 1.630 0.236