ENSG00000126804

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000358738 ENSG00000126804 HEK293_OSMI2_2hA HEK293_TMG_2hB ZBTB1 protein_coding protein_coding 7.404835 1.899534 13.63749 0.2189212 0.4914181 2.837344 0.51751960 0.08267498 1.42299125 0.06686723 0.06811683 3.950706 0.05957083 0.04196667 0.104300000 0.06233333 0.23413278 0.02781288 FALSE TRUE
ENST00000553583 ENSG00000126804 HEK293_OSMI2_2hA HEK293_TMG_2hB ZBTB1 protein_coding protein_coding 7.404835 1.899534 13.63749 0.2189212 0.4914181 2.837344 2.42615844 0.14896630 5.48058840 0.14896630 0.45364197 5.110168 0.24471250 0.06913333 0.401400000 0.33226667 0.06598868 0.02781288 FALSE TRUE
ENST00000555321 ENSG00000126804 HEK293_OSMI2_2hA HEK293_TMG_2hB ZBTB1 protein_coding protein_coding 7.404835 1.899534 13.63749 0.2189212 0.4914181 2.837344 0.86955051 0.09733041 1.92204563 0.09733041 0.24609900 4.169998 0.11239583 0.04680000 0.140066667 0.09326667 0.25253739 0.02781288 FALSE TRUE
ENST00000556965 ENSG00000126804 HEK293_OSMI2_2hA HEK293_TMG_2hB ZBTB1 protein_coding protein_coding 7.404835 1.899534 13.63749 0.2189212 0.4914181 2.837344 0.54736730 0.00000000 0.00000000 0.00000000 0.00000000 0.000000 0.08226667 0.00000000 0.000000000 0.00000000   0.02781288 FALSE TRUE
ENST00000683701 ENSG00000126804 HEK293_OSMI2_2hA HEK293_TMG_2hB ZBTB1 protein_coding protein_coding 7.404835 1.899534 13.63749 0.2189212 0.4914181 2.837344 2.55716650 1.19259395 3.98432962 0.05994352 0.29994631 1.731804 0.42022083 0.65046667 0.294433333 -0.35603333 0.02781288 0.02781288 FALSE TRUE
MSTRG.9711.5 ENSG00000126804 HEK293_OSMI2_2hA HEK293_TMG_2hB ZBTB1 protein_coding   7.404835 1.899534 13.63749 0.2189212 0.4914181 2.837344 0.05325462 0.13009968 0.04012995 0.13009968 0.04012995 -1.482709 0.02273333 0.06036667 0.003133333 -0.05723333 0.68124413 0.02781288 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000126804 E001 0.0000000       14 64503712 64503724 13 +      
ENSG00000126804 E002 0.1451727 0.0428580216 1.000000e+00   14 64503725 64503822 98 + 0.059 0.000 -7.658
ENSG00000126804 E003 0.1482932 0.0414904977 7.666986e-02   14 64503823 64503893 71 + 0.000 0.237 11.507
ENSG00000126804 E004 0.7405235 0.0165526306 2.115507e-01 3.403246e-01 14 64503894 64503897 4 + 0.157 0.389 1.732
ENSG00000126804 E005 3.2827287 0.0049243910 1.781344e-02 4.673650e-02 14 64503898 64503950 53 + 0.461 0.833 1.618
ENSG00000126804 E006 3.9438446 0.0039716207 1.831923e-02 4.782969e-02 14 64503951 64503984 34 + 0.523 0.877 1.489
ENSG00000126804 E007 6.2106711 0.0027065607 1.644389e-01 2.809565e-01 14 64503985 64504050 66 + 0.730 0.917 0.734
ENSG00000126804 E008 5.7646457 0.0031000711 4.045242e-01 5.482395e-01 14 64504051 64504091 41 + 0.718 0.834 0.462
ENSG00000126804 E009 6.7581688 0.0028462450 3.223731e-01 4.656736e-01 14 64504574 64504725 152 + 0.834 0.666 -0.681
ENSG00000126804 E010 7.0811462 0.0043275983 1.203945e-01 2.205294e-01 14 64504726 64504769 44 + 0.861 0.592 -1.107
ENSG00000126804 E011 6.1922278 0.0188975577 1.039869e-01 1.965701e-01 14 64504770 64504776 7 + 0.816 0.503 -1.344
ENSG00000126804 E012 7.5367247 0.0484678085 5.690123e-02 1.212941e-01 14 64504777 64504781 5 + 0.896 0.503 -1.651
ENSG00000126804 E013 24.9773826 0.0007521999 1.314183e-04 6.650854e-04 14 64504782 64504946 165 + 1.375 0.954 -1.507
ENSG00000126804 E014 6.0594729 0.0039313402 8.758572e-01 9.242676e-01 14 64511249 64511384 136 + 0.764 0.730 -0.139
ENSG00000126804 E015 10.2321286 0.0016554639 9.849356e-01 9.946055e-01 14 64516600 64516751 152 + 0.962 0.954 -0.029
ENSG00000126804 E016 390.8123838 0.0032150703 5.835878e-05 3.233496e-04 14 64521487 64523402 1916 + 2.507 2.420 -0.289
ENSG00000126804 E017 100.4604117 0.0034908132 4.613921e-13 1.195914e-11 14 64523403 64524951 1549 + 1.830 2.127 0.999
ENSG00000126804 E018 47.3571650 0.0007620650 4.007745e-01 5.444486e-01 14 64531861 64533690 1830 + 1.595 1.528 -0.227