ENSG00000126773

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000391611 ENSG00000126773 HEK293_OSMI2_2hA HEK293_TMG_2hB PCNX4 protein_coding protein_coding 14.66797 3.994206 22.5568 0.2239732 0.3253896 2.494614 1.1889239 0.9349448 1.685509 0.127776416 0.08810355 0.8434161 0.1214042 0.2321000 0.07486667 -0.157233333 5.215396e-08 5.215396e-08 FALSE TRUE
ENST00000406854 ENSG00000126773 HEK293_OSMI2_2hA HEK293_TMG_2hB PCNX4 protein_coding protein_coding 14.66797 3.994206 22.5568 0.2239732 0.3253896 2.494614 0.8734516 0.2087228 1.282250 0.001951629 0.20217676 2.5627095 0.0645625 0.0526000 0.05673333 0.004133333 9.464510e-01 5.215396e-08 FALSE TRUE
ENST00000406949 ENSG00000126773 HEK293_OSMI2_2hA HEK293_TMG_2hB PCNX4 protein_coding protein_coding 14.66797 3.994206 22.5568 0.2239732 0.3253896 2.494614 6.5373613 1.1743109 11.319613 0.228867745 0.83371835 3.2579788 0.3727167 0.3007667 0.50310000 0.202333333 1.686727e-01 5.215396e-08 FALSE TRUE
ENST00000483571 ENSG00000126773 HEK293_OSMI2_2hA HEK293_TMG_2hB PCNX4 protein_coding retained_intron 14.66797 3.994206 22.5568 0.2239732 0.3253896 2.494614 2.6805893 1.4234021 3.023372 0.290938352 1.05248265 1.0814790 0.2233083 0.3513667 0.13283333 -0.218533333 4.763916e-02 5.215396e-08 FALSE TRUE
ENST00000553513 ENSG00000126773 HEK293_OSMI2_2hA HEK293_TMG_2hB PCNX4 protein_coding retained_intron 14.66797 3.994206 22.5568 0.2239732 0.3253896 2.494614 0.9619544 0.0000000 1.842714 0.000000000 0.58626985 7.5334961 0.0807875 0.0000000 0.08130000 0.081300000 5.668419e-04 5.215396e-08 FALSE FALSE
MSTRG.9657.8 ENSG00000126773 HEK293_OSMI2_2hA HEK293_TMG_2hB PCNX4 protein_coding   14.66797 3.994206 22.5568 0.2239732 0.3253896 2.494614 1.6045882 0.0000000 1.888137 0.000000000 0.31182973 7.5684402 0.0821625 0.0000000 0.08370000 0.083700000 6.050308e-07 5.215396e-08 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000126773 E001 0.3686942 0.0306970262 2.600756e-01 3.975547e-01 14 60091911 60091918 8 + 0.059 0.238 2.328
ENSG00000126773 E002 0.3686942 0.0306970262 2.600756e-01 3.975547e-01 14 60091919 60091922 4 + 0.059 0.238 2.328
ENSG00000126773 E003 0.5159433 0.2819224962 4.940109e-01 6.310327e-01 14 60091923 60091926 4 + 0.111 0.241 1.353
ENSG00000126773 E004 10.4253580 0.0016751488 4.880908e-01 6.257039e-01 14 60091927 60091976 50 + 0.940 1.049 0.404
ENSG00000126773 E005 14.8227839 0.0078244909 6.438443e-01 7.562942e-01 14 60091977 60092001 25 + 1.106 1.077 -0.105
ENSG00000126773 E006 30.2336105 0.0006558664 2.076019e-01 3.356076e-01 14 60092002 60092136 135 + 1.408 1.330 -0.268
ENSG00000126773 E007 24.0604055 0.0007842372 8.160697e-03 2.419020e-02 14 60092137 60092185 49 + 1.338 1.102 -0.835
ENSG00000126773 E008 65.2063275 0.0081381793 1.040633e-04 5.407795e-04 14 60092186 60092419 234 + 1.761 1.481 -0.952
ENSG00000126773 E009 106.9187485 0.0003690957 4.169819e-09 5.508401e-08 14 60107586 60108327 742 + 1.973 1.710 -0.886
ENSG00000126773 E010 85.1561596 0.0144137977 8.345532e-27 1.058257e-24 14 60108328 60111157 2830 + 1.550 2.317 2.581
ENSG00000126773 E011 80.5170483 0.0022491263 5.443721e-05 3.039214e-04 14 60114700 60114879 180 + 1.844 1.629 -0.726
ENSG00000126773 E012 1.0267042 0.0140862852 2.130580e-01 3.421526e-01 14 60114880 60114973 94 + 0.305 0.000 -11.781
ENSG00000126773 E013 131.0031688 0.0056799990 1.286169e-06 1.043382e-05 14 60114974 60115343 370 + 2.059 1.805 -0.854
ENSG00000126773 E014 76.6198356 0.0003724764 1.957316e-03 7.093267e-03 14 60115344 60115461 118 + 1.813 1.671 -0.479
ENSG00000126773 E015 3.5064432 0.0045124218 2.279412e-01 3.599735e-01 14 60115621 60115718 98 + 0.608 0.390 -1.067
ENSG00000126773 E016 80.2379881 0.0013485142 2.676753e-03 9.302931e-03 14 60115719 60115819 101 + 1.832 1.691 -0.474
ENSG00000126773 E017 57.8273005 0.0010067758 6.568403e-03 2.010379e-02 14 60115941 60115981 41 + 1.694 1.547 -0.499
ENSG00000126773 E018 72.6822786 0.0022360061 6.034397e-03 1.870110e-02 14 60115982 60116060 79 + 1.789 1.651 -0.467
ENSG00000126773 E019 0.4482035 0.0282211018 7.497011e-01 8.365747e-01 14 60116683 60116733 51 + 0.157 0.000 -10.520
ENSG00000126773 E020 54.3027280 0.0005135598 2.566448e-02 6.324794e-02 14 60118329 60118376 48 + 1.662 1.547 -0.392
ENSG00000126773 E021 67.9193896 0.0003870237 1.275915e-01 2.307926e-01 14 60118377 60118442 66 + 1.748 1.691 -0.193
ENSG00000126773 E022 81.4389148 0.0011783307 2.741835e-01 4.133173e-01 14 60118443 60118574 132 + 1.822 1.794 -0.097
ENSG00000126773 E023 57.9329054 0.0004722574 1.001206e-01 1.906573e-01 14 60118575 60118623 49 + 1.685 1.613 -0.243
ENSG00000126773 E024 67.2075635 0.0021999754 4.366086e-01 5.786678e-01 14 60118624 60118692 69 + 1.739 1.722 -0.057
ENSG00000126773 E025 79.3006844 0.0029398549 7.622537e-01 8.458898e-01 14 60121196 60121299 104 + 1.805 1.817 0.043
ENSG00000126773 E026 63.3752973 0.0018414962 7.627865e-01 8.463176e-01 14 60124218 60124305 88 + 1.706 1.716 0.033
ENSG00000126773 E027 36.2378260 0.0041730803 2.007618e-01 3.271465e-01 14 60124306 60124310 5 + 1.443 1.565 0.419
ENSG00000126773 E028 168.3009808 0.0002442111 3.199056e-01 4.629882e-01 14 60124311 60124713 403 + 2.116 2.177 0.205
ENSG00000126773 E029 238.8719757 0.0002156792 1.485517e-01 2.597026e-01 14 60124714 60125251 538 + 2.266 2.334 0.228
ENSG00000126773 E030 133.0751446 0.0002474690 3.726851e-03 1.237474e-02 14 60125637 60125823 187 + 1.999 2.133 0.446
ENSG00000126773 E031 3.1666902 0.0160539733 4.894105e-01 6.268370e-01 14 60125824 60126190 367 + 0.522 0.666 0.644
ENSG00000126773 E032 5.1527181 0.0154236361 3.147607e-02 7.483932e-02 14 60133656 60133785 130 + 0.608 0.955 1.393
ENSG00000126773 E033 393.4515615 0.0022987503 4.073130e-04 1.802818e-03 14 60133970 60147324 13355 + 2.468 2.594 0.420
ENSG00000126773 E034 0.1515154 0.0429584694 1.000000e+00   14 60147325 60147407 83 + 0.059 0.000 -8.861
ENSG00000126773 E035 1.1543840 0.2004788997 4.730135e-01 6.120384e-01 14 60147408 60148221 814 + 0.238 0.394 1.019
ENSG00000126773 E036 0.1515154 0.0429584694 1.000000e+00   14 60159633 60159667 35 + 0.059 0.000 -8.861
ENSG00000126773 E037 0.1515154 0.0429584694 1.000000e+00   14 60168692 60169133 442 + 0.059 0.000 -8.861