ENSG00000126767

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000247161 ENSG00000126767 HEK293_OSMI2_2hA HEK293_TMG_2hB ELK1 protein_coding protein_coding 49.47526 79.16373 36.42965 5.980486 0.7777158 -1.119513 33.40959 58.89240 18.131533 3.809180 1.3781191 -1.6990300 0.63781250 0.7453667 0.4965333 -0.24883333 1.009618e-08 1.337327e-55 FALSE TRUE
ENST00000376983 ENSG00000126767 HEK293_OSMI2_2hA HEK293_TMG_2hB ELK1 protein_coding protein_coding 49.47526 79.16373 36.42965 5.980486 0.7777158 -1.119513 13.02946 20.17615 11.671311 2.374012 0.2110052 -0.7891634 0.27465000 0.2533333 0.3209000 0.06756667 6.687395e-02 1.337327e-55 FALSE TRUE
MSTRG.34190.3 ENSG00000126767 HEK293_OSMI2_2hA HEK293_TMG_2hB ELK1 protein_coding   49.47526 79.16373 36.42965 5.980486 0.7777158 -1.119513 2.91066 0.00000 6.467099 0.000000 0.4465084 9.3392039 0.08477083 0.0000000 0.1781667 0.17816667 1.337327e-55 1.337327e-55 TRUE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000126767 E001 1225.705109 0.0047835287 1.234953e-09 1.797742e-08 X 47635521 47636217 697 - 2.846 3.067 0.736
ENSG00000126767 E002 1758.656626 0.0010707665 2.046797e-01 3.319851e-01 X 47636218 47636810 593 - 3.143 3.190 0.156
ENSG00000126767 E003 499.973024 0.0001565902 3.531852e-08 3.919735e-07 X 47636811 47636927 117 - 2.685 2.612 -0.243
ENSG00000126767 E004 294.839539 0.0003202317 3.733384e-02 8.609911e-02 X 47637013 47637052 40 - 2.419 2.393 -0.085
ENSG00000126767 E005 321.492251 0.0001845664 9.473682e-01 9.709258e-01 X 47637053 47637114 62 - 2.418 2.444 0.087
ENSG00000126767 E006 813.198737 0.0011573030 2.224448e-01 3.533180e-01 X 47637751 47638182 432 - 2.840 2.843 0.012
ENSG00000126767 E007 786.637828 0.0036540287 9.630184e-02 1.848327e-01 X 47638895 47639278 384 - 2.843 2.824 -0.061
ENSG00000126767 E008 307.814375 0.0050432501 8.411281e-02 1.659917e-01 X 47639279 47639338 60 - 2.449 2.412 -0.122
ENSG00000126767 E009 644.765978 0.0025154388 2.952433e-03 1.012379e-02 X 47641232 47641475 244 - 2.779 2.730 -0.164
ENSG00000126767 E010 2.512959 0.0068174170 5.417321e-02 1.165543e-01 X 47648887 47649367 481 - 0.713 0.419 -1.358
ENSG00000126767 E011 117.839572 0.0043648088 5.691770e-04 2.418447e-03 X 47649921 47650026 106 - 2.104 1.970 -0.448
ENSG00000126767 E012 309.274385 0.0017828588 4.099228e-02 9.286777e-02 X 47650423 47650604 182 - 2.448 2.415 -0.110