ENSG00000126746

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000319770 ENSG00000126746 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF384 protein_coding protein_coding 49.81662 52.62265 47.37433 3.477939 1.077377 -0.1515482 2.683811 4.9476672 1.078480 0.3943793 0.54636289 -2.18734616 0.05374583 0.09553333 0.02323333 -0.07230000 3.570797e-01 3.467773e-11 FALSE TRUE
ENST00000355772 ENSG00000126746 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF384 protein_coding protein_coding 49.81662 52.62265 47.37433 3.477939 1.077377 -0.1515482 12.457219 19.3937266 8.628576 1.1132072 0.41033618 -1.16746829 0.24465417 0.36916667 0.18266667 -0.18650000 3.467773e-11 3.467773e-11 FALSE TRUE
ENST00000361959 ENSG00000126746 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF384 protein_coding protein_coding 49.81662 52.62265 47.37433 3.477939 1.077377 -0.1515482 7.319683 5.3240027 6.448366 1.6568926 0.64055250 0.27595060 0.14606250 0.09790000 0.13680000 0.03890000 5.869680e-01 3.467773e-11 FALSE TRUE
ENST00000396801 ENSG00000126746 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF384 protein_coding protein_coding 49.81662 52.62265 47.37433 3.477939 1.077377 -0.1515482 1.887663 4.3409060 1.520515 1.2219826 0.76348332 -1.50729907 0.03772500 0.08620000 0.03143333 -0.05476667 6.009426e-01 3.467773e-11 FALSE TRUE
ENST00000535485 ENSG00000126746 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF384 protein_coding protein_coding 49.81662 52.62265 47.37433 3.477939 1.077377 -0.1515482 8.184202 7.7908399 7.991138 0.8849225 0.06138325 0.03657574 0.16547500 0.14726667 0.16890000 0.02163333 4.730576e-01 3.467773e-11 FALSE FALSE
ENST00000537248 ENSG00000126746 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF384 protein_coding retained_intron 49.81662 52.62265 47.37433 3.477939 1.077377 -0.1515482 2.275220 0.4495909 3.094374 0.1982740 0.46524014 2.75588020 0.04781250 0.00810000 0.06493333 0.05683333 1.307701e-03 3.467773e-11 FALSE TRUE
ENST00000542519 ENSG00000126746 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF384 protein_coding retained_intron 49.81662 52.62265 47.37433 3.477939 1.077377 -0.1515482 3.369885 1.2237708 4.724832 0.3847786 0.97231211 1.94023899 0.07009583 0.02250000 0.09896667 0.07646667 3.464231e-03 3.467773e-11 FALSE TRUE
MSTRG.6703.6 ENSG00000126746 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF384 protein_coding   49.81662 52.62265 47.37433 3.477939 1.077377 -0.1515482 5.172852 3.0139461 5.813507 0.4934667 0.15159365 0.94545587 0.10526667 0.05686667 0.12273333 0.06586667 1.361690e-05 3.467773e-11 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000126746 E001 31.575628 0.0092377643 9.978355e-04 3.950698e-03 12 6666477 6666647 171 - 1.294 1.579 0.983
ENSG00000126746 E002 42.439994 0.0055316228 5.666925e-05 3.149627e-04 12 6666648 6666729 82 - 1.413 1.707 1.003
ENSG00000126746 E003 31.548372 0.0012832938 8.180036e-05 4.365305e-04 12 6666730 6666737 8 - 1.294 1.580 0.989
ENSG00000126746 E004 665.427906 0.0025818814 6.353658e-15 2.156362e-13 12 6666738 6667225 488 - 2.651 2.878 0.752
ENSG00000126746 E005 723.644246 0.0007213745 1.391610e-18 7.523868e-17 12 6667226 6667684 459 - 2.727 2.899 0.573
ENSG00000126746 E006 123.373509 0.0003004272 1.589357e-04 7.870428e-04 12 6667685 6667691 7 - 1.983 2.126 0.477
ENSG00000126746 E007 404.472840 0.0005135895 1.758689e-05 1.104483e-04 12 6667692 6668064 373 - 2.522 2.625 0.344
ENSG00000126746 E008 191.206194 0.0002294675 4.346018e-01 5.769273e-01 12 6668065 6668115 51 - 2.242 2.277 0.117
ENSG00000126746 E009 321.346256 0.0001417831 4.871050e-01 6.248051e-01 12 6669031 6669189 159 - 2.472 2.500 0.095
ENSG00000126746 E010 276.172620 0.0001895012 9.192355e-01 9.529581e-01 12 6670760 6670838 79 - 2.416 2.432 0.055
ENSG00000126746 E011 6.291237 0.0237747311 5.849724e-04 2.478059e-03 12 6672041 6672349 309 - 1.089 0.628 -1.797
ENSG00000126746 E012 60.170920 0.0055732101 1.337254e-01 2.393330e-01 12 6672350 6672403 54 - 1.817 1.745 -0.241
ENSG00000126746 E013 87.721512 0.0003218469 2.875420e-01 4.280490e-01 12 6672404 6672532 129 - 1.949 1.922 -0.091
ENSG00000126746 E014 2.295856 0.0061685938 1.983629e-03 7.175723e-03 12 6673060 6673215 156 - 0.753 0.259 -2.514
ENSG00000126746 E015 212.657384 0.0001876464 2.800202e-01 4.198210e-01 12 6673216 6673247 32 - 2.319 2.306 -0.043
ENSG00000126746 E016 404.758075 0.0001569203 3.286476e-01 4.721272e-01 12 6673248 6673440 193 - 2.591 2.588 -0.012
ENSG00000126746 E017 12.220613 0.0014307006 1.755066e-03 6.456281e-03 12 6677167 6677259 93 - 1.258 0.975 -1.018
ENSG00000126746 E018 226.772421 0.0004794474 6.693677e-02 1.382815e-01 12 6678127 6678200 74 - 2.358 2.326 -0.109
ENSG00000126746 E019 181.043132 0.0002538073 3.561178e-01 5.005041e-01 12 6678201 6678260 60 - 2.248 2.237 -0.037
ENSG00000126746 E020 246.940301 0.0001612673 2.397309e-06 1.833076e-05 12 6678261 6678343 83 - 2.434 2.340 -0.312
ENSG00000126746 E021 268.108291 0.0006840999 9.645602e-07 8.028339e-06 12 6678344 6678431 88 - 2.478 2.373 -0.351
ENSG00000126746 E022 173.735044 0.0002253583 5.818796e-05 3.225425e-04 12 6678432 6678460 29 - 2.285 2.189 -0.320
ENSG00000126746 E023 15.916405 0.0285572217 2.265671e-06 1.741347e-05 12 6678461 6678542 82 - 1.475 0.923 -1.965
ENSG00000126746 E024 3.113913 0.0069234101 5.428732e-05 3.031739e-04 12 6678661 6678662 2 - 0.881 0.260 -3.015
ENSG00000126746 E025 42.541960 0.0005123256 7.389843e-06 5.058293e-05 12 6678663 6678664 2 - 1.753 1.527 -0.767
ENSG00000126746 E026 73.563063 0.0041059273 9.808099e-07 8.150699e-06 12 6678665 6678710 46 - 1.992 1.759 -0.784
ENSG00000126746 E027 19.345685 0.0678814721 5.764548e-08 6.128030e-07 12 6678810 6678945 136 - 1.622 0.803 -2.933
ENSG00000126746 E028 387.198238 0.0001461606 2.780986e-10 4.550829e-09 12 6678946 6679183 238 - 2.632 2.530 -0.337
ENSG00000126746 E029 2.284228 0.0065044077 1.089424e-02 3.091124e-02 12 6679220 6679454 235 - 0.722 0.320 -1.974
ENSG00000126746 E030 178.435639 0.0030970342 4.549011e-02 1.010947e-01 12 6679455 6679521 67 - 2.271 2.211 -0.198
ENSG00000126746 E031 92.566322 0.0005163272 2.767753e-01 4.162543e-01 12 6679522 6679525 4 - 1.969 1.942 -0.093
ENSG00000126746 E032 147.152067 0.0035395873 1.400032e-01 2.480239e-01 12 6688167 6688226 60 - 2.178 2.134 -0.148
ENSG00000126746 E033 66.523185 0.0070109311 2.371423e-02 5.922368e-02 12 6688227 6688452 226 - 1.881 1.764 -0.397
ENSG00000126746 E034 80.342924 0.0025296904 2.352691e-06 1.801650e-05 12 6688453 6688689 237 - 2.007 1.805 -0.680
ENSG00000126746 E035 34.734984 0.0078703949 3.089167e-03 1.052805e-02 12 6688703 6688726 24 - 1.652 1.452 -0.687
ENSG00000126746 E036 50.629718 0.0014029793 9.418952e-06 6.298151e-05 12 6688727 6688836 110 - 1.819 1.605 -0.727
ENSG00000126746 E037 29.198132 0.0080669404 8.777362e-03 2.572669e-02 12 6688837 6689097 261 - 1.574 1.388 -0.642
ENSG00000126746 E038 34.406760 0.0077407897 2.621716e-01 3.999233e-01 12 6689098 6689367 270 - 1.566 1.499 -0.228
ENSG00000126746 E039 46.068096 0.0163077130 5.016322e-01 6.377735e-01 12 6689368 6689572 205 - 1.675 1.639 -0.120