ENSG00000126705

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000247087 ENSG00000126705 HEK293_OSMI2_2hA HEK293_TMG_2hB AHDC1 protein_coding protein_coding 4.069189 4.398723 4.586825 0.5349231 0.2623977 0.06027692 0.1840086 0.25790914 0.04676733 0.09326564 0.04676733 -2.2386110 0.04137917 0.06336667 0.01053333 -0.05283333 2.379792e-01 1.879503e-08 FALSE TRUE
ENST00000374011 ENSG00000126705 HEK293_OSMI2_2hA HEK293_TMG_2hB AHDC1 protein_coding protein_coding 4.069189 4.398723 4.586825 0.5349231 0.2623977 0.06027692 0.3973432 0.61263626 0.34002801 0.26122694 0.17002691 -0.8309192 0.09834583 0.12800000 0.07856667 -0.04943333 7.826732e-01 1.879503e-08 FALSE TRUE
ENST00000490295 ENSG00000126705 HEK293_OSMI2_2hA HEK293_TMG_2hB AHDC1 protein_coding processed_transcript 4.069189 4.398723 4.586825 0.5349231 0.2623977 0.06027692 0.1797911 0.04228707 0.47463974 0.02116660 0.20724946 3.2123866 0.04405417 0.01070000 0.09960000 0.08890000 2.482530e-02 1.879503e-08 FALSE FALSE
ENST00000642245 ENSG00000126705 HEK293_OSMI2_2hA HEK293_TMG_2hB AHDC1 protein_coding protein_coding 4.069189 4.398723 4.586825 0.5349231 0.2623977 0.06027692 0.2608655 0.07448170 1.03044101 0.07448170 0.18214437 3.6224125 0.06027917 0.01510000 0.22340000 0.20830000 3.438353e-03 1.879503e-08 FALSE TRUE
ENST00000643219 ENSG00000126705 HEK293_OSMI2_2hA HEK293_TMG_2hB AHDC1 protein_coding processed_transcript 4.069189 4.398723 4.586825 0.5349231 0.2623977 0.06027692 0.4769806 0.20324717 0.68604620 0.20324717 0.34988453 1.7066565 0.12017917 0.04123333 0.14560000 0.10436667 5.678503e-01 1.879503e-08 TRUE FALSE
ENST00000644989 ENSG00000126705 HEK293_OSMI2_2hA HEK293_TMG_2hB AHDC1 protein_coding protein_coding 4.069189 4.398723 4.586825 0.5349231 0.2623977 0.06027692 0.4326364 0.90736428 0.00000000 0.24485104 0.00000000 -6.5194228 0.10853333 0.21126667 0.00000000 -0.21126667 1.879503e-08 1.879503e-08 FALSE TRUE
ENST00000673934 ENSG00000126705 HEK293_OSMI2_2hA HEK293_TMG_2hB AHDC1 protein_coding protein_coding 4.069189 4.398723 4.586825 0.5349231 0.2623977 0.06027692 1.3058272 1.78306593 1.15649570 0.07872944 0.08704730 -0.6202476 0.32485000 0.41450000 0.25263333 -0.16186667 2.328581e-02 1.879503e-08 FALSE TRUE
MSTRG.648.7 ENSG00000126705 HEK293_OSMI2_2hA HEK293_TMG_2hB AHDC1 protein_coding   4.069189 4.398723 4.586825 0.5349231 0.2623977 0.06027692 0.3014299 0.00000000 0.00000000 0.00000000 0.00000000 0.0000000 0.07298750 0.00000000 0.00000000 0.00000000   1.879503e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000126705 E001 0.1817044 0.0391584391 6.977584e-01   1 27534035 27534244 210 - 0.000 0.106 9.046
ENSG00000126705 E002 0.0000000       1 27534245 27534272 28 -      
ENSG00000126705 E003 0.7268175 0.7760204373 4.030138e-01 5.468115e-01 1 27534273 27534302 30 - 0.000 0.327 12.206
ENSG00000126705 E004 39.6600308 0.0030078530 4.046114e-09 5.360683e-08 1 27534303 27534660 358 - 1.279 1.709 1.477
ENSG00000126705 E005 14.7640540 0.0012687484 3.888418e-05 2.248006e-04 1 27534661 27534684 24 - 0.853 1.297 1.619
ENSG00000126705 E006 14.1071662 0.0013738052 4.621389e-05 2.626078e-04 1 27534685 27534714 30 - 0.829 1.278 1.647
ENSG00000126705 E007 11.2745946 0.0139737056 3.528742e-04 1.591387e-03 1 27534715 27534735 21 - 0.717 1.196 1.803
ENSG00000126705 E008 26.3935562 0.0025475605 1.357332e-05 8.743669e-05 1 27534736 27534916 181 - 1.158 1.527 1.284
ENSG00000126705 E009 402.0260833 0.0069150535 7.479996e-03 2.246133e-02 1 27547261 27550868 3608 - 2.520 2.627 0.355
ENSG00000126705 E010 68.4033542 0.0373123573 4.227865e-01 5.659229e-01 1 27550869 27551667 799 - 1.832 1.820 -0.042
ENSG00000126705 E011 22.1610209 0.0188278418 7.231972e-01 8.170774e-01 1 27551668 27551850 183 - 1.336 1.345 0.033
ENSG00000126705 E012 10.5447162 0.0083788667 4.607034e-01 6.006920e-01 1 27551851 27552038 188 - 1.069 1.019 -0.182
ENSG00000126705 E013 6.7473324 0.0025087273 2.125577e-01 3.415676e-01 1 27552039 27552189 151 - 0.937 0.815 -0.468
ENSG00000126705 E014 1.2168277 0.0108647759 5.853684e-03 1.822753e-02 1 27552496 27552772 277 - 0.566 0.106 -3.277
ENSG00000126705 E015 1.0287806 0.0119442233 7.268520e-04 2.995430e-03 1 27552773 27552891 119 - 0.566 0.000 -15.359
ENSG00000126705 E016 13.8519489 0.0014243683 5.451855e-03 1.715962e-02 1 27552892 27552929 38 - 1.270 1.051 -0.782
ENSG00000126705 E017 17.7830143 0.0010906192 6.508031e-02 1.351626e-01 1 27553074 27553140 67 - 1.320 1.203 -0.414
ENSG00000126705 E018 10.2657850 0.0024842339 5.209430e-01 6.548758e-01 1 27553141 27553145 5 - 1.055 1.017 -0.136
ENSG00000126705 E019 15.9686352 0.0053387159 8.666600e-02 1.700671e-01 1 27553146 27553185 40 - 1.279 1.156 -0.433
ENSG00000126705 E020 3.0550490 0.1028101044 4.945349e-01 6.314825e-01 1 27553186 27553225 40 - 0.465 0.643 0.824
ENSG00000126705 E021 5.5772915 0.0940540927 6.089697e-01 7.285509e-01 1 27553226 27553290 65 - 0.684 0.847 0.656
ENSG00000126705 E022 2.2255690 0.3506014706 7.346331e-01 8.255475e-01 1 27553291 27553298 8 - 0.463 0.514 0.255
ENSG00000126705 E023 2.5222571 0.2290551205 8.602777e-01 9.138609e-01 1 27553299 27553304 6 - 0.565 0.513 -0.241
ENSG00000126705 E024 0.5922303 0.0180026400 1.618583e-01 2.775537e-01 1 27553305 27553545 241 - 0.332 0.106 -2.056
ENSG00000126705 E025 13.9027630 0.0037253167 1.274065e-02 3.530161e-02 1 27558305 27558328 24 - 1.261 1.062 -0.709
ENSG00000126705 E026 28.0754412 0.0007159255 6.064155e-06 4.235964e-05 1 27558329 27558530 202 - 1.586 1.326 -0.893
ENSG00000126705 E027 26.1662805 0.0007453222 3.190525e-06 2.372754e-05 1 27558706 27558813 108 - 1.568 1.291 -0.958
ENSG00000126705 E028 18.4707674 0.0010875423 1.031396e-04 5.365925e-04 1 27558814 27558883 70 - 1.420 1.146 -0.959
ENSG00000126705 E029 0.2944980 0.3782566959 1.838911e-01   1 27568026 27568260 235 - 0.247 0.000 -12.649
ENSG00000126705 E030 15.8992281 0.0011511802 2.194128e-03 7.823622e-03 1 27603397 27603491 95 - 1.336 1.110 -0.798
ENSG00000126705 E031 4.8027750 0.0034553113 2.750883e-04 1.278354e-03 1 27603492 27603494 3 - 0.974 0.507 -1.928
ENSG00000126705 E032 1.2480608 0.0108647759 2.080565e-01 3.361535e-01 1 27603495 27603633 139 - 0.465 0.262 -1.207
ENSG00000126705 E033 13.7026367 0.0016504289 7.870356e-03 2.345433e-02 1 27603728 27603863 136 - 1.261 1.051 -0.750
ENSG00000126705 E034 9.2668623 0.0019165270 4.475975e-02 9.976821e-02 1 27603864 27604105 242 - 1.097 0.914 -0.675
ENSG00000126705 E035 1.9261286 0.0086462938 6.747583e-02 1.391568e-01 1 27604106 27604109 4 - 0.609 0.324 -1.469
ENSG00000126705 E036 2.5173148 0.0070560968 5.265496e-03 1.665413e-02 1 27604110 27604159 50 - 0.748 0.324 -2.054
ENSG00000126705 E037 0.3289534 0.0291990458 7.694004e-01   1 27604160 27604431 272 - 0.141 0.106 -0.469