ENSG00000126581

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000361523 ENSG00000126581 HEK293_OSMI2_2hA HEK293_TMG_2hB BECN1 protein_coding protein_coding 37.02228 28.89119 49.16175 3.884511 0.4064938 0.7667009 6.2203723 8.785722 5.820912 0.9273052 0.9130905 -0.5930804 0.18616250 0.30790000 0.1185000 -0.18940000 9.248672e-05 2.244118e-55 FALSE TRUE
ENST00000588276 ENSG00000126581 HEK293_OSMI2_2hA HEK293_TMG_2hB BECN1 protein_coding protein_coding 37.02228 28.89119 49.16175 3.884511 0.4064938 0.7667009 0.9965942 3.064517 0.000000 1.5686405 0.0000000 -8.2642158 0.03256667 0.09700000 0.0000000 -0.09700000 9.449953e-02 2.244118e-55 FALSE FALSE
ENST00000590099 ENSG00000126581 HEK293_OSMI2_2hA HEK293_TMG_2hB BECN1 protein_coding protein_coding 37.02228 28.89119 49.16175 3.884511 0.4064938 0.7667009 14.1697364 10.022335 21.296822 1.6230633 0.3628110 1.0866580 0.37030833 0.34433333 0.4333333 0.08900000 7.390321e-03 2.244118e-55 FALSE TRUE
MSTRG.14377.10 ENSG00000126581 HEK293_OSMI2_2hA HEK293_TMG_2hB BECN1 protein_coding   37.02228 28.89119 49.16175 3.884511 0.4064938 0.7667009 3.9281280 0.000000 6.928923 0.0000000 0.2093055 9.4385680 0.09560000 0.00000000 0.1409000 0.14090000 2.244118e-55 2.244118e-55 FALSE TRUE
MSTRG.14377.7 ENSG00000126581 HEK293_OSMI2_2hA HEK293_TMG_2hB BECN1 protein_coding   37.02228 28.89119 49.16175 3.884511 0.4064938 0.7667009 0.9189568 2.046170 0.000000 0.6668575 0.0000000 -7.6838160 0.03016250 0.07836667 0.0000000 -0.07836667 8.887043e-10 2.244118e-55 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000126581 E001 140.1001941 0.0008449029 3.807198e-13 9.974585e-12 17 42810134 42810287 154 - 2.031 2.267 0.792
ENSG00000126581 E002 111.6823887 0.0002918077 9.487730e-13 2.338262e-11 17 42810288 42810307 20 - 1.930 2.172 0.808
ENSG00000126581 E003 98.7344484 0.0003462970 2.109976e-11 4.165141e-10 17 42810308 42810309 2 - 1.878 2.119 0.809
ENSG00000126581 E004 241.1011849 0.0007389607 1.735670e-16 7.250662e-15 17 42810310 42810413 104 - 2.279 2.491 0.707
ENSG00000126581 E005 190.6081915 0.0007478029 3.881465e-15 1.358632e-13 17 42810414 42810515 102 - 2.172 2.395 0.745
ENSG00000126581 E006 237.3213804 0.0001736232 2.228594e-23 2.052506e-21 17 42810516 42810669 154 - 2.260 2.491 0.770
ENSG00000126581 E007 174.7250798 0.0012883299 2.829238e-06 2.129821e-05 17 42810670 42810715 46 - 2.175 2.318 0.477
ENSG00000126581 E008 192.5358069 0.0018508649 1.914200e-02 4.964671e-02 17 42810716 42810779 64 - 2.256 2.327 0.239
ENSG00000126581 E009 212.6616478 0.0002359408 1.169297e-01 2.155805e-01 17 42810780 42810859 80 - 2.317 2.357 0.132
ENSG00000126581 E010 221.7454442 0.0002501771 8.522052e-01 9.083926e-01 17 42810860 42810928 69 - 2.351 2.357 0.019
ENSG00000126581 E011 162.1185008 0.0029651596 3.919109e-01 5.358541e-01 17 42811655 42811723 69 - 2.231 2.202 -0.096
ENSG00000126581 E012 163.2719465 0.0002988507 1.944431e-02 5.029764e-02 17 42811724 42811797 74 - 2.250 2.186 -0.215
ENSG00000126581 E013 22.7115496 0.0008298393 7.892398e-03 2.350855e-02 17 42811798 42812230 433 - 1.457 1.261 -0.678
ENSG00000126581 E014 16.5243359 0.0022094185 1.826364e-01 3.045043e-01 17 42812231 42812356 126 - 1.302 1.192 -0.389
ENSG00000126581 E015 6.8601843 0.0409390639 3.196862e-01 4.627733e-01 17 42812357 42812866 510 - 0.967 0.824 -0.548
ENSG00000126581 E016 19.5813987 0.0008955934 1.053646e-04 5.467723e-04 17 42813548 42813902 355 - 1.435 1.123 -1.096
ENSG00000126581 E017 3.9126141 0.0048018996 4.084795e-03 1.338011e-02 17 42813903 42813947 45 - 0.850 0.404 -1.986
ENSG00000126581 E018 131.8028772 0.0008015351 9.287664e-02 1.796320e-01 17 42813948 42814008 61 - 2.153 2.098 -0.185
ENSG00000126581 E019 9.4076375 0.0229941930 2.735896e-02 6.672424e-02 17 42814009 42814167 159 - 1.128 0.831 -1.106
ENSG00000126581 E020 14.1725574 0.0385516185 4.781600e-01 6.166128e-01 17 42814168 42814523 356 - 1.224 1.148 -0.271
ENSG00000126581 E021 178.6192792 0.0002547101 8.557020e-01 9.107803e-01 17 42814524 42814598 75 - 2.263 2.259 -0.012
ENSG00000126581 E022 191.1795014 0.0001887445 5.755478e-01 7.011362e-01 17 42814599 42814673 75 - 2.295 2.282 -0.044
ENSG00000126581 E023 11.1832727 0.0017500821 3.986163e-04 1.769079e-03 17 42814674 42815014 341 - 1.224 0.853 -1.359
ENSG00000126581 E024 2.2743126 0.2605845884 3.961669e-01 5.399587e-01 17 42815670 42815670 1 - 0.608 0.340 -1.362
ENSG00000126581 E025 8.6560699 0.0019159866 1.032972e-04 5.373386e-04 17 42815671 42815772 102 - 1.145 0.684 -1.759
ENSG00000126581 E026 6.8352674 0.0023484410 4.680035e-02 1.034681e-01 17 42815773 42815907 135 - 0.993 0.748 -0.941
ENSG00000126581 E027 271.1765926 0.0010763085 4.023240e-01 5.460601e-01 17 42815908 42816054 147 - 2.428 2.446 0.060
ENSG00000126581 E028 390.4112457 0.0001503876 2.662718e-02 6.521830e-02 17 42818221 42818415 195 - 2.614 2.575 -0.132
ENSG00000126581 E029 287.0693281 0.0003797900 1.046981e-10 1.841665e-09 17 42818544 42818650 107 - 2.524 2.379 -0.484
ENSG00000126581 E030 179.6955909 0.0005980380 3.101720e-08 3.479151e-07 17 42818651 42818680 30 - 2.326 2.166 -0.536
ENSG00000126581 E031 10.9559972 0.0016378641 1.246281e-01 2.266006e-01 17 42818681 42818786 106 - 1.145 0.992 -0.557
ENSG00000126581 E032 233.9673209 0.0001765536 1.130265e-07 1.137029e-06 17 42818787 42818877 91 - 2.428 2.303 -0.415
ENSG00000126581 E033 18.4848283 0.0045039109 7.278810e-01 8.204512e-01 17 42818878 42819027 150 - 1.308 1.279 -0.103
ENSG00000126581 E034 13.0985872 0.0153882854 5.710482e-02 1.216473e-01 17 42819028 42819132 105 - 1.238 1.024 -0.768
ENSG00000126581 E035 20.1144319 0.0009473390 4.507122e-01 5.917743e-01 17 42819133 42819323 191 - 1.353 1.296 -0.197
ENSG00000126581 E036 25.1573568 0.0007686635 7.888227e-02 1.577271e-01 17 42819324 42819547 224 - 1.473 1.352 -0.419
ENSG00000126581 E037 173.3705154 0.0002456209 1.613656e-05 1.022519e-04 17 42819548 42819609 62 - 2.298 2.181 -0.391
ENSG00000126581 E038 0.7331366 0.0182801774 3.074833e-01 4.497146e-01 17 42820351 42820522 172 - 0.323 0.141 -1.527
ENSG00000126581 E039 2.1285602 0.0249883917 3.288466e-01 4.723343e-01 17 42820523 42820773 251 - 0.575 0.403 -0.850
ENSG00000126581 E040 120.5217112 0.0002346232 6.482594e-04 2.709910e-03 17 42820774 42820793 20 - 2.137 2.027 -0.369
ENSG00000126581 E041 180.8182095 0.0002426247 4.756309e-07 4.225012e-06 17 42820794 42820841 48 - 2.319 2.183 -0.455
ENSG00000126581 E042 5.2744178 0.0032132849 2.791417e-01 4.188519e-01 17 42823705 42823747 43 - 0.734 0.876 0.561
ENSG00000126581 E043 205.7266530 0.0002528984 3.359819e-04 1.524387e-03 17 42823748 42823817 70 - 2.357 2.266 -0.304
ENSG00000126581 E044 167.7039441 0.0036740849 4.227856e-02 9.523415e-02 17 42823818 42823879 62 - 2.267 2.177 -0.302
ENSG00000126581 E045 42.5489204 0.0005182811 1.677184e-01 2.852273e-01 17 42824133 42824154 22 - 1.673 1.599 -0.251
ENSG00000126581 E046 156.1783854 0.0072467022 8.218243e-02 1.629499e-01 17 42824155 42824379 225 - 2.240 2.139 -0.337
ENSG00000126581 E047 0.6192988 0.0236936331 4.970682e-01 6.336230e-01 17 42825176 42825232 57 - 0.262 0.141 -1.110
ENSG00000126581 E048 0.0000000       17 42825233 42825278 46 -      
ENSG00000126581 E049 0.5483223 0.0277114981 3.894366e-01 5.335259e-01 17 42827251 42827341 91 - 0.106 0.248 1.478
ENSG00000126581 E050 2.3133810 0.0472614975 1.612703e-02 4.301480e-02 17 42833118 42833350 233 - 0.262 0.687 2.221