ENSG00000126457

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000391851 ENSG00000126457 HEK293_OSMI2_2hA HEK293_TMG_2hB PRMT1 protein_coding protein_coding 576.2548 992.0184 340.1615 35.90099 5.451579 -1.544119 101.27991 178.7956597 55.49465 10.4260162 1.875214 -1.687712 0.17266250 0.1799333 0.16320000 -0.01673333 0.383800970 1.765353e-13 FALSE  
ENST00000454376 ENSG00000126457 HEK293_OSMI2_2hA HEK293_TMG_2hB PRMT1 protein_coding protein_coding 576.2548 992.0184 340.1615 35.90099 5.451579 -1.544119 61.50821 123.9127174 32.47227 2.6776504 2.612984 -1.931716 0.10070000 0.1253333 0.09546667 -0.02986667 0.130342011 1.765353e-13 FALSE  
ENST00000527382 ENSG00000126457 HEK293_OSMI2_2hA HEK293_TMG_2hB PRMT1 protein_coding protein_coding 576.2548 992.0184 340.1615 35.90099 5.451579 -1.544119 19.04350 0.4917911 26.21310 0.4917911 10.893424 5.707607 0.04309583 0.0005000 0.07636667 0.07586667 0.001759434 1.765353e-13 FALSE  
MSTRG.17514.12 ENSG00000126457 HEK293_OSMI2_2hA HEK293_TMG_2hB PRMT1 protein_coding   576.2548 992.0184 340.1615 35.90099 5.451579 -1.544119 349.29838 630.3361009 192.65750 22.2681532 7.084004 -1.710031 0.59549583 0.6354333 0.56696667 -0.06846667 0.188075395 1.765353e-13 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000126457 E001 12.102756 0.0019444167 4.005359e-01 5.442258e-01 19 49675786 49675896 111 + 1.078 0.994 -0.307
ENSG00000126457 E002 81.782858 0.0003585604 1.163032e-03 4.515665e-03 19 49675897 49676225 329 + 1.917 1.780 -0.463
ENSG00000126457 E003 52.994365 0.0004229495 6.616389e-04 2.758302e-03 19 49676226 49676240 15 + 1.766 1.590 -0.598
ENSG00000126457 E004 51.461289 0.0004676301 1.036606e-04 5.388740e-04 19 49676241 49676260 20 + 1.775 1.572 -0.689
ENSG00000126457 E005 64.471026 0.0003933988 1.372903e-02 3.760570e-02 19 49676261 49676345 85 + 1.805 1.690 -0.390
ENSG00000126457 E006 74.763145 0.0019351748 3.589221e-02 8.337427e-02 19 49676346 49676439 94 + 1.856 1.759 -0.327
ENSG00000126457 E007 3.640921 0.0055029505 8.485207e-01 9.059611e-01 19 49677057 49677072 16 + 0.536 0.578 0.191
ENSG00000126457 E008 10.868089 0.0115723533 2.500253e-01 3.859379e-01 19 49677073 49677151 79 + 1.078 0.947 -0.484
ENSG00000126457 E009 8.954751 0.0270859979 2.053786e-01 3.328923e-01 19 49677152 49677172 21 + 1.031 0.863 -0.630
ENSG00000126457 E010 7.378860 0.0254581517 2.311010e-02 5.797708e-02 19 49677173 49677182 10 + 1.055 0.745 -1.184
ENSG00000126457 E011 366.864746 0.0024599818 1.904241e-13 5.207171e-12 19 49677183 49677248 66 + 2.629 2.407 -0.739
ENSG00000126457 E012 1052.732465 0.0029706190 7.946789e-01 8.688424e-01 19 49677249 49677266 18 + 2.912 2.918 0.021
ENSG00000126457 E013 1187.373795 0.0030819021 9.636695e-01 9.810801e-01 19 49677267 49677270 4 + 2.959 2.972 0.044
ENSG00000126457 E014 1406.960438 0.0026449058 7.051785e-01 8.035823e-01 19 49677271 49677276 6 + 3.040 3.044 0.013
ENSG00000126457 E015 1979.374277 0.0024221689 5.099423e-01 6.452083e-01 19 49677277 49677293 17 + 3.165 3.197 0.106
ENSG00000126457 E016 2339.939312 0.0024003243 4.875566e-01 6.252235e-01 19 49677294 49677316 23 + 3.238 3.270 0.108
ENSG00000126457 E017 15.206283 0.0191058261 4.260330e-01 5.689059e-01 19 49677317 49677358 42 + 1.177 1.095 -0.294
ENSG00000126457 E018 1.938344 0.0576102745 7.769512e-01 8.564003e-01 19 49677502 49677597 96 + 0.346 0.410 0.364
ENSG00000126457 E019 2.357388 0.0100442802 9.112392e-01 9.476305e-01 19 49678225 49678272 48 + 0.452 0.438 -0.072
ENSG00000126457 E020 2.650640 0.0111392637 7.550127e-01 8.404819e-01 19 49679775 49679871 97 + 0.536 0.489 -0.229
ENSG00000126457 E021 522.586588 0.0018743189 2.279938e-02 5.732510e-02 19 49679872 49679925 54 + 2.655 2.602 -0.174
ENSG00000126457 E022 40.838334 0.0005342296 2.603222e-04 1.218071e-03 19 49679926 49679929 4 + 1.681 1.467 -0.729
ENSG00000126457 E023 11.339346 0.0015212158 1.844968e-01 3.068528e-01 19 49679930 49680119 190 + 1.100 0.962 -0.504
ENSG00000126457 E024 93.372967 0.0004543088 1.050823e-10 1.847566e-09 19 49680140 49680238 99 + 2.061 1.804 -0.862
ENSG00000126457 E025 33.686789 0.0006733547 3.393697e-04 1.537902e-03 19 49680239 49680253 15 + 1.609 1.379 -0.789
ENSG00000126457 E026 4312.331771 0.0013993004 3.639069e-01 5.083269e-01 19 49680487 49680588 102 + 3.532 3.529 -0.009
ENSG00000126457 E027 2398.060083 0.0005679643 9.795117e-02 1.873881e-01 19 49681910 49681912 3 + 3.282 3.272 -0.035
ENSG00000126457 E028 6473.357099 0.0004086215 3.414345e-02 8.003927e-02 19 49681913 49682065 153 + 3.712 3.704 -0.028
ENSG00000126457 E029 4898.327988 0.0001368208 1.346830e-03 5.132621e-03 19 49682196 49682259 64 + 3.595 3.582 -0.044
ENSG00000126457 E030 15.695491 0.0393176745 5.361195e-01 6.678737e-01 19 49683635 49683926 292 + 1.032 1.137 0.382
ENSG00000126457 E031 7206.409557 0.0002039686 1.583310e-01 2.729081e-01 19 49683927 49684069 143 + 3.751 3.753 0.007
ENSG00000126457 E032 5390.800639 0.0001361915 8.829139e-01 9.290816e-01 19 49684754 49684826 73 + 3.616 3.628 0.040
ENSG00000126457 E033 2981.793182 0.0001772954 2.971054e-04 1.368051e-03 19 49684827 49684841 15 + 3.388 3.364 -0.078
ENSG00000126457 E034 25.335348 0.0109231475 8.122325e-05 4.337807e-04 19 49684842 49684921 80 + 1.568 1.237 -1.145
ENSG00000126457 E035 5959.082247 0.0003166112 6.262106e-01 7.421937e-01 19 49684922 49685037 116 + 3.655 3.674 0.061
ENSG00000126457 E036 23.816776 0.0008141345 2.666280e-08 3.032472e-07 19 49685038 49685161 124 + 1.582 1.178 -1.402
ENSG00000126457 E037 25.934269 0.0128282739 1.761787e-12 4.146667e-11 19 49685162 49685304 143 + 1.727 1.129 -2.074
ENSG00000126457 E038 34.463010 0.0158502216 3.918159e-13 1.023980e-11 19 49685305 49685639 335 + 1.844 1.246 -2.052
ENSG00000126457 E039 42.465122 0.0008840082 3.137986e-21 2.309565e-19 19 49685724 49686092 369 + 1.898 1.379 -1.767
ENSG00000126457 E040 2765.825713 0.0012891634 6.969957e-02 1.428674e-01 19 49686093 49686095 3 + 3.297 3.346 0.163
ENSG00000126457 E041 7429.752560 0.0010197516 1.405140e-02 3.834126e-02 19 49686096 49686243 148 + 3.724 3.776 0.173
ENSG00000126457 E042 6789.157590 0.0008793672 6.353921e-03 1.954236e-02 19 49686605 49686726 122 + 3.683 3.737 0.179
ENSG00000126457 E043 64.360999 0.0003823928 2.423859e-32 4.808301e-30 19 49686930 49687039 110 + 2.077 1.549 -1.782
ENSG00000126457 E044 55.399112 0.0004338574 8.263046e-07 6.986094e-06 19 49687853 49687952 100 + 1.833 1.584 -0.844
ENSG00000126457 E045 4900.094211 0.0004042646 1.644959e-09 2.342934e-08 19 49688162 49689029 868 + 3.517 3.600 0.274