ENSG00000126456

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000377139 ENSG00000126456 HEK293_OSMI2_2hA HEK293_TMG_2hB IRF3 protein_coding protein_coding 70.39675 127.4381 37.03321 4.099948 0.5547114 -1.782628 21.912617 46.132154 9.734840 0.4161859 0.6487395 -2.2433749 0.28712083 0.36250000 0.26346667 -0.09903333 2.123542e-02 2.943756e-12 FALSE  
ENST00000597369 ENSG00000126456 HEK293_OSMI2_2hA HEK293_TMG_2hB IRF3 protein_coding retained_intron 70.39675 127.4381 37.03321 4.099948 0.5547114 -1.782628 3.076374 2.191410 2.715517 0.2806429 0.3276903 0.3081024 0.05881250 0.01720000 0.07326667 0.05606667 2.795956e-09 2.943756e-12    
ENST00000597636 ENSG00000126456 HEK293_OSMI2_2hA HEK293_TMG_2hB IRF3 protein_coding nonsense_mediated_decay 70.39675 127.4381 37.03321 4.099948 0.5547114 -1.782628 2.945063 1.783076 2.515943 0.1439190 0.2465229 0.4943855 0.05604583 0.01406667 0.06813333 0.05406667 2.943756e-12 2.943756e-12 TRUE  
ENST00000599144 ENSG00000126456 HEK293_OSMI2_2hA HEK293_TMG_2hB IRF3 protein_coding protein_coding 70.39675 127.4381 37.03321 4.099948 0.5547114 -1.782628 10.756727 20.939319 5.473378 0.7974481 0.2463375 -1.9337666 0.14745417 0.16503333 0.14800000 -0.01703333 7.071325e-01 2.943756e-12 FALSE  
ENST00000601291 ENSG00000126456 HEK293_OSMI2_2hA HEK293_TMG_2hB IRF3 protein_coding protein_coding 70.39675 127.4381 37.03321 4.099948 0.5547114 -1.782628 6.279005 13.723690 2.361610 1.3399288 0.3961389 -2.5337806 0.07963333 0.10783333 0.06366667 -0.04416667 1.162807e-01 2.943756e-12 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000126456 E001 0.5900522 0.3252907502 6.914079e-01 7.928931e-01 19 49659569 49659569 1 - 0.222 0.163 -0.550
ENSG00000126456 E002 0.8114974 0.0379558312 9.675006e-01 9.836695e-01 19 49659570 49659571 2 - 0.222 0.213 -0.081
ENSG00000126456 E003 3.4370556 0.2334998693 2.222968e-01 3.531527e-01 19 49659572 49659572 1 - 0.222 0.603 2.174
ENSG00000126456 E004 3.4370556 0.2334998693 2.222968e-01 3.531527e-01 19 49659573 49659574 2 - 0.222 0.603 2.174
ENSG00000126456 E005 21.2815924 0.0129069310 5.952008e-01 7.173240e-01 19 49659575 49659578 4 - 1.177 1.242 0.232
ENSG00000126456 E006 107.7320530 0.0029197729 4.262367e-02 9.585507e-02 19 49659579 49659631 53 - 1.814 1.927 0.381
ENSG00000126456 E007 414.9044488 0.0042375721 1.905603e-01 3.144583e-01 19 49659632 49659757 126 - 2.443 2.499 0.185
ENSG00000126456 E008 420.6241165 0.0027842251 2.835239e-02 6.871098e-02 19 49659758 49659833 76 - 2.428 2.508 0.265
ENSG00000126456 E009 519.2668749 0.0011646933 2.554117e-03 8.924852e-03 19 49660713 49660828 116 - 2.515 2.599 0.280
ENSG00000126456 E010 48.2932301 0.0008145990 9.570482e-01 9.770749e-01 19 49660829 49660844 16 - 1.561 1.561 -0.002
ENSG00000126456 E011 8.1979234 0.0022791988 2.107674e-03 7.557635e-03 19 49660845 49661003 159 - 1.137 0.772 -1.370
ENSG00000126456 E012 22.1737139 0.0009052820 4.304983e-12 9.515413e-11 19 49661450 49661594 145 - 1.628 1.105 -1.821
ENSG00000126456 E013 10.0546713 0.0017645277 8.189259e-04 3.327037e-03 19 49661595 49661625 31 - 1.214 0.846 -1.352
ENSG00000126456 E014 28.4746738 0.0031301324 2.038413e-18 1.080502e-16 19 49661626 49661947 322 - 1.777 1.161 -2.125
ENSG00000126456 E015 575.5700125 0.0001558499 1.516219e-04 7.542554e-04 19 49661948 49662068 121 - 2.562 2.642 0.267
ENSG00000126456 E016 470.6583382 0.0001824636 1.434963e-02 3.902517e-02 19 49662069 49662132 64 - 2.494 2.551 0.191
ENSG00000126456 E017 421.9485625 0.0010099131 1.266131e-01 2.294281e-01 19 49662133 49662174 42 - 2.459 2.503 0.148
ENSG00000126456 E018 499.8729244 0.0009537610 5.380858e-02 1.159238e-01 19 49662175 49662238 64 - 2.525 2.577 0.173
ENSG00000126456 E019 449.9723157 0.0002555773 2.668393e-01 4.051024e-01 19 49662239 49662300 62 - 2.498 2.527 0.094
ENSG00000126456 E020 393.8477212 0.0001572978 3.882863e-01 5.323891e-01 19 49662301 49662328 28 - 2.447 2.470 0.078
ENSG00000126456 E021 8.6576736 0.0288857531 2.942063e-02 7.081337e-02 19 49662329 49662329 1 - 1.092 0.789 -1.139
ENSG00000126456 E022 7.8710967 0.0792753546 8.144200e-03 2.414847e-02 19 49662375 49662424 50 - 1.157 0.718 -1.663
ENSG00000126456 E023 310.2338496 0.0001545233 9.570716e-01 9.770881e-01 19 49662425 49662426 2 - 2.361 2.362 0.006
ENSG00000126456 E024 434.3125246 0.0001261119 8.995702e-01 9.399182e-01 19 49662427 49662453 27 - 2.503 2.509 0.019
ENSG00000126456 E025 649.0310938 0.0001124441 7.922163e-01 8.671208e-01 19 49662454 49662538 85 - 2.675 2.682 0.026
ENSG00000126456 E026 478.4300837 0.0001397799 3.311668e-01 4.747526e-01 19 49662539 49662584 46 - 2.529 2.554 0.080
ENSG00000126456 E027 310.1119167 0.0002087019 2.121533e-01 3.410739e-01 19 49662585 49662592 8 - 2.329 2.366 0.123
ENSG00000126456 E028 354.5022480 0.0001604843 1.622804e-01 2.780862e-01 19 49662593 49662617 25 - 2.387 2.425 0.128
ENSG00000126456 E029 503.9893759 0.0002788273 6.632799e-01 7.713740e-01 19 49663188 49663235 48 - 2.576 2.570 -0.020
ENSG00000126456 E030 389.3683087 0.0001488723 4.743533e-01 6.131953e-01 19 49663236 49663258 23 - 2.471 2.457 -0.046
ENSG00000126456 E031 14.3235030 0.0012523247 1.617368e-07 1.578515e-06 19 49663259 49663342 84 - 1.421 0.935 -1.738
ENSG00000126456 E032 299.7783271 0.0004129359 1.815049e-01 3.031296e-01 19 49663343 49663372 30 - 2.373 2.340 -0.112
ENSG00000126456 E033 354.8619526 0.0008706118 6.292584e-01 7.446571e-01 19 49663373 49663420 48 - 2.426 2.416 -0.033
ENSG00000126456 E034 410.2062932 0.0014791679 4.908125e-01 6.281486e-01 19 49663421 49663514 94 - 2.462 2.485 0.078
ENSG00000126456 E035 32.1043234 0.0037862296 1.199139e-17 5.818990e-16 19 49663515 49663919 405 - 1.809 1.223 -2.014
ENSG00000126456 E036 12.6997388 0.0013926373 1.647247e-05 1.041435e-04 19 49664443 49664552 110 - 1.337 0.910 -1.538
ENSG00000126456 E037 23.1438445 0.0008519014 1.790215e-02 4.692635e-02 19 49664553 49664586 34 - 1.410 1.214 -0.684
ENSG00000126456 E038 46.0051735 0.0004941840 9.530742e-05 4.999780e-04 19 49664587 49664673 87 - 1.725 1.493 -0.790
ENSG00000126456 E039 430.1293434 0.0014567560 5.078142e-01 6.432460e-01 19 49664674 49664846 173 - 2.484 2.506 0.072
ENSG00000126456 E040 33.7886987 0.0057836162 3.248430e-07 2.983696e-06 19 49664847 49664950 104 - 1.697 1.321 -1.291
ENSG00000126456 E041 63.4420946 0.0003937459 2.012889e-35 5.037460e-33 19 49664951 49665458 508 - 2.091 1.519 -1.933
ENSG00000126456 E042 16.6739681 0.0017906708 9.553233e-06 6.379919e-05 19 49665459 49665483 25 - 1.421 1.022 -1.415
ENSG00000126456 E043 41.5831992 0.0042329541 6.292518e-14 1.839658e-12 19 49665484 49665630 147 - 1.852 1.370 -1.643
ENSG00000126456 E044 156.1054319 0.0015732273 1.280910e-01 2.315104e-01 19 49665631 49665634 4 - 2.114 2.055 -0.196
ENSG00000126456 E045 276.1533242 0.0006750043 8.243183e-01 8.893163e-01 19 49665635 49665671 37 - 2.303 2.312 0.031
ENSG00000126456 E046 381.2565927 0.0002457580 2.263039e-01 3.579638e-01 19 49665672 49665875 204 - 2.472 2.446 -0.087