ENSG00000126247

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000246533 ENSG00000126247 HEK293_OSMI2_2hA HEK293_TMG_2hB CAPNS1 protein_coding protein_coding 563.0505 1019.017 341.611 12.96425 1.494648 -1.576723 100.7476 184.5966 57.07984 10.53254 1.322852 -1.693148 0.1770875 0.1809667 0.1671000 -0.01386667 6.441621e-01 4.455453e-06 FALSE TRUE
ENST00000590049 ENSG00000126247 HEK293_OSMI2_2hA HEK293_TMG_2hB CAPNS1 protein_coding non_stop_decay 563.0505 1019.017 341.611 12.96425 1.494648 -1.576723 223.9939 360.4059 164.77005 15.68433 3.765455 -1.129121 0.4241542 0.3534333 0.4823667 0.12893333 4.455453e-06 4.455453e-06 FALSE FALSE
ENST00000629983 ENSG00000126247 HEK293_OSMI2_2hA HEK293_TMG_2hB CAPNS1 protein_coding protein_coding 563.0505 1019.017 341.611 12.96425 1.494648 -1.576723 204.6579 422.1921 99.65426 20.02233 2.324496 -2.082786 0.3380292 0.4148333 0.2917333 -0.12310000 1.769776e-03 4.455453e-06   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000126247 E001 10.9077219 7.564819e-03 1.342731e-02 3.691010e-02 19 36139953 36140014 62 + 0.657 1.031 1.461
ENSG00000126247 E002 32.2929710 6.654281e-04 1.148465e-02 3.231744e-02 19 36140015 36140065 51 + 1.243 1.465 0.771
ENSG00000126247 E003 128.9383200 9.202060e-03 3.477411e-01 4.919390e-01 19 36140066 36140107 42 + 2.046 2.008 -0.127
ENSG00000126247 E004 129.2075802 1.261417e-02 1.780610e-01 2.987082e-01 19 36140108 36140109 2 + 2.073 2.003 -0.235
ENSG00000126247 E005 140.2397501 1.267297e-02 2.919964e-01 4.329316e-01 19 36140110 36140122 13 + 2.092 2.042 -0.165
ENSG00000126247 E006 141.0878519 1.356904e-02 3.645011e-01 5.088479e-01 19 36140123 36140126 4 + 2.088 2.047 -0.137
ENSG00000126247 E007 154.7736011 1.122254e-02 2.282460e-01 3.603287e-01 19 36140127 36140157 31 + 2.137 2.083 -0.180
ENSG00000126247 E008 7.4900499 7.943898e-02 8.993124e-01 9.397609e-01 19 36140158 36140265 108 + 0.801 0.841 0.157
ENSG00000126247 E009 3.5730820 4.560009e-03 2.705622e-01 4.092194e-01 19 36140358 36140511 154 + 0.710 0.546 -0.716
ENSG00000126247 E010 4.6123278 6.764319e-02 4.395147e-01 5.812669e-01 19 36140608 36140913 306 + 0.757 0.632 -0.522
ENSG00000126247 E011 5.5743227 5.859320e-02 2.425913e-01 3.771982e-01 19 36140968 36140996 29 + 0.875 0.683 -0.766
ENSG00000126247 E012 117.8940533 1.220792e-02 1.330129e-01 2.383060e-01 19 36140997 36140999 3 + 2.037 1.960 -0.259
ENSG00000126247 E013 157.1196886 1.026928e-02 2.037133e-01 3.308461e-01 19 36141000 36141011 12 + 2.145 2.089 -0.185
ENSG00000126247 E014 154.9451507 1.029600e-02 1.884428e-01 3.117679e-01 19 36141012 36141075 64 + 2.141 2.083 -0.195
ENSG00000126247 E015 15.7844769 6.562098e-02 1.108005e-02 3.135860e-02 19 36141076 36141158 83 + 1.392 1.026 -1.297
ENSG00000126247 E016 118.8991967 1.419944e-03 3.317902e-05 1.951949e-04 19 36141159 36141178 20 + 2.097 1.944 -0.513
ENSG00000126247 E017 286.8439858 3.237258e-03 1.542070e-01 2.673884e-01 19 36141179 36141189 11 + 2.388 2.354 -0.117
ENSG00000126247 E018 659.4059257 3.159724e-03 1.044906e-01 1.973367e-01 19 36141190 36141220 31 + 2.749 2.716 -0.112
ENSG00000126247 E019 1.1854902 1.487515e-02 2.427472e-01 3.774127e-01 19 36141303 36141564 262 + 0.442 0.235 -1.301
ENSG00000126247 E020 0.2965864 2.121617e-01 1.000000e+00   19 36141593 36141683 91 + 0.000 0.131 8.285
ENSG00000126247 E021 1110.9871091 3.039306e-03 2.906923e-02 7.013958e-02 19 36142300 36142333 34 + 2.985 2.940 -0.151
ENSG00000126247 E022 1252.5097941 2.198701e-03 4.793953e-03 1.535782e-02 19 36142652 36142681 30 + 3.043 2.990 -0.178
ENSG00000126247 E023 1955.0902587 6.471124e-04 4.429773e-05 2.528114e-04 19 36142682 36142741 60 + 3.229 3.185 -0.147
ENSG00000126247 E024 2599.5961695 7.164897e-04 3.263399e-05 1.924486e-04 19 36142909 36142966 58 + 3.353 3.309 -0.145
ENSG00000126247 E025 2743.0250109 5.758263e-04 6.798766e-10 1.040561e-08 19 36143064 36143128 65 + 3.393 3.328 -0.218
ENSG00000126247 E026 2.1003563 6.739063e-03 2.055486e-01 3.331044e-01 19 36145373 36145775 403 + 0.597 0.387 -1.039
ENSG00000126247 E027 3.3967754 5.545022e-02 4.466165e-01 5.881097e-01 19 36145776 36145805 30 + 0.657 0.527 -0.582
ENSG00000126247 E028 3346.9966141 3.231639e-04 1.619868e-12 3.832636e-11 19 36145806 36145874 69 + 3.473 3.415 -0.193
ENSG00000126247 E029 3278.9745588 4.838515e-05 8.246514e-16 3.150388e-14 19 36145976 36146036 61 + 3.454 3.409 -0.150
ENSG00000126247 E030 2213.8902712 4.809131e-05 1.901229e-04 9.217005e-04 19 36146037 36146054 18 + 3.263 3.244 -0.060
ENSG00000126247 E031 2898.3543630 5.735580e-05 9.836322e-01 9.938462e-01 19 36146196 36146246 51 + 3.351 3.368 0.056
ENSG00000126247 E032 2539.4243724 2.929830e-04 5.188140e-01 6.529791e-01 19 36146247 36146290 44 + 3.288 3.313 0.083
ENSG00000126247 E033 1882.1016096 5.703330e-05 2.279760e-10 3.778928e-09 19 36146291 36146312 22 + 3.108 3.193 0.281
ENSG00000126247 E034 2635.6034005 1.654688e-04 1.023075e-09 1.514917e-08 19 36149578 36149636 59 + 3.258 3.339 0.268
ENSG00000126247 E035 17.3639379 3.688044e-02 3.712687e-01 5.156996e-01 19 36149637 36149812 176 + 1.258 1.152 -0.376
ENSG00000126247 E036 5784.5429683 1.451889e-03 2.459911e-07 2.317138e-06 19 36149813 36150041 229 + 3.577 3.686 0.363
ENSG00000126247 E037 4651.0629583 2.857382e-03 2.077201e-06 1.610145e-05 19 36150042 36150313 272 + 3.459 3.596 0.457
ENSG00000126247 E038 674.0127729 5.672957e-03 5.470373e-07 4.802344e-06 19 36150314 36150353 40 + 2.542 2.772 0.765