ENSG00000126216

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000261965 ENSG00000126216 HEK293_OSMI2_2hA HEK293_TMG_2hB TUBGCP3 protein_coding protein_coding 9.158477 6.117664 11.4122 0.3054671 0.172341 0.8984311 5.578147 3.5912912 6.6252011 0.29228300 0.3208405 0.8816259 0.5978375 0.5853333 0.58130000 -0.004033333 9.963446e-01 1.862952e-07 FALSE TRUE
ENST00000375669 ENSG00000126216 HEK293_OSMI2_2hA HEK293_TMG_2hB TUBGCP3 protein_coding protein_coding 9.158477 6.117664 11.4122 0.3054671 0.172341 0.8984311 1.547256 0.3157245 3.3376379 0.05031933 0.5425006 3.3614195 0.1401250 0.0511000 0.29116667 0.240066667 1.862952e-07 1.862952e-07 FALSE TRUE
ENST00000464139 ENSG00000126216 HEK293_OSMI2_2hA HEK293_TMG_2hB TUBGCP3 protein_coding protein_coding 9.158477 6.117664 11.4122 0.3054671 0.172341 0.8984311 1.134360 1.9037126 0.7893436 0.06760663 0.1600488 -1.2594865 0.1578917 0.3136000 0.06956667 -0.244033333 3.259071e-07 1.862952e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000126216 E001 2.3457510 0.2339623426 4.277715e-01 5.706000e-01 13 112485011 112485032 22 - 0.469 0.599 0.613
ENSG00000126216 E002 103.2133926 0.0003147842 2.249403e-21 1.685024e-19 13 112485033 112485843 811 - 1.853 2.175 1.079
ENSG00000126216 E003 80.8950920 0.0028333153 4.291383e-01 5.718674e-01 13 112485844 112486151 308 - 1.895 1.930 0.120
ENSG00000126216 E004 58.1397874 0.0035678953 3.124877e-01 4.550195e-01 13 112489581 112489697 117 - 1.744 1.795 0.173
ENSG00000126216 E005 0.0000000       13 112489698 112489823 126 -      
ENSG00000126216 E006 4.5296384 0.0036354985 1.393425e-03 5.285419e-03 13 112498807 112498936 130 - 0.505 0.945 1.828
ENSG00000126216 E007 62.7671106 0.0003996288 2.213438e-01 3.520402e-01 13 112499045 112499185 141 - 1.779 1.831 0.175
ENSG00000126216 E008 59.0841018 0.0149779977 7.399447e-01 8.295015e-01 13 112504032 112504163 132 - 1.782 1.770 -0.042
ENSG00000126216 E009 45.1129887 0.0061998584 3.305258e-01 4.741135e-01 13 112504626 112504714 89 - 1.687 1.626 -0.208
ENSG00000126216 E010 66.4486749 0.0107532832 7.383268e-02 1.496449e-01 13 112516440 112516575 136 - 1.868 1.758 -0.372
ENSG00000126216 E011 49.6007111 0.0034716148 2.786933e-01 4.183546e-01 13 112518975 112519043 69 - 1.726 1.666 -0.207
ENSG00000126216 E012 70.3183921 0.0044605466 4.576148e-02 1.015982e-01 13 112519886 112520021 136 - 1.890 1.782 -0.365
ENSG00000126216 E013 0.8815316 0.0131482458 4.262583e-02 9.585877e-02 13 112521663 112521864 202 - 0.392 0.000 -11.998
ENSG00000126216 E014 65.5101070 0.0110431298 1.181977e-01 2.173451e-01 13 112522320 112522509 190 - 1.860 1.751 -0.369
ENSG00000126216 E015 50.8199776 0.0110450506 2.473503e-02 6.133076e-02 13 112526942 112527050 109 - 1.770 1.601 -0.574
ENSG00000126216 E016 58.5955768 0.0276953258 4.817787e-02 1.059510e-01 13 112527374 112527484 111 - 1.838 1.640 -0.672
ENSG00000126216 E017 6.1161424 0.0030615854 8.309582e-04 3.369561e-03 13 112544556 112545698 1143 - 0.645 1.057 1.604
ENSG00000126216 E018 71.3616973 0.0006029110 3.111570e-05 1.844827e-04 13 112545699 112545865 167 - 1.919 1.731 -0.634
ENSG00000126216 E019 1.6992580 0.1320898058 9.923827e-01 9.993245e-01 13 112545866 112546203 338 - 0.433 0.434 0.005
ENSG00000126216 E020 58.5678523 0.0098807460 2.579863e-29 4.083102e-27 13 112546482 112547619 1138 - 1.297 2.061 2.601
ENSG00000126216 E021 68.8994831 0.0010069988 8.971850e-01 9.383347e-01 13 112547620 112547752 133 - 1.838 1.829 -0.033
ENSG00000126216 E022 42.4138975 0.0007614424 6.878378e-01 7.900879e-01 13 112548108 112548176 69 - 1.641 1.616 -0.084
ENSG00000126216 E023 64.7378754 0.0011491793 5.546118e-01 6.835662e-01 13 112554057 112554182 126 - 1.801 1.825 0.081
ENSG00000126216 E024 70.7433618 0.0016931604 5.727876e-01 6.988478e-01 13 112554887 112555005 119 - 1.861 1.831 -0.100
ENSG00000126216 E025 80.4743616 0.0048171642 5.346470e-02 1.153193e-01 13 112556052 112556220 169 - 1.943 1.837 -0.357
ENSG00000126216 E026 23.0954842 0.0008614627 2.209696e-01 3.515956e-01 13 112556221 112556224 4 - 1.413 1.321 -0.321
ENSG00000126216 E027 76.4247826 0.0004725465 5.549273e-03 1.741618e-02 13 112558196 112558413 218 - 1.927 1.808 -0.401
ENSG00000126216 E028 43.7661467 0.0051247035 3.974867e-01 5.412407e-01 13 112559322 112559399 78 - 1.665 1.603 -0.209
ENSG00000126216 E029 34.5357317 0.0034114049 9.136776e-01 9.493313e-01 13 112565111 112565178 68 - 1.540 1.542 0.006
ENSG00000126216 E030 33.4905982 0.0008442383 4.494838e-02 1.001050e-01 13 112569152 112569259 108 - 1.576 1.445 -0.446
ENSG00000126216 E031 0.2987644 0.0274151391 4.175889e-01   13 112584039 112584161 123 - 0.173 0.000 -10.414
ENSG00000126216 E032 0.1472490 0.0440746995 8.730126e-01   13 112587230 112587346 117 - 0.095 0.000 -9.414
ENSG00000126216 E033 30.3944607 0.0202381093 1.612363e-02 4.300884e-02 13 112587905 112588205 301 - 1.569 1.325 -0.842