ENSG00000126106

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000372235 ENSG00000126106 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM53 protein_coding protein_coding 8.933733 15.70838 4.193701 0.4742487 0.1940846 -1.902721 4.5825061 8.1978524 1.5992099 0.24870771 0.22924230 -2.3506523 0.50701250 0.52253333 0.37980000 -0.14273333 9.819804e-02 2.269671e-05 FALSE TRUE
ENST00000372237 ENSG00000126106 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM53 protein_coding protein_coding 8.933733 15.70838 4.193701 0.4742487 0.1940846 -1.902721 0.7655835 1.5095984 0.5645708 0.25829657 0.03355301 -1.4031335 0.08695417 0.09540000 0.13556667 0.04016667 4.266786e-01 2.269671e-05 FALSE TRUE
ENST00000372242 ENSG00000126106 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM53 protein_coding protein_coding 8.933733 15.70838 4.193701 0.4742487 0.1940846 -1.902721 1.2141657 2.1240288 0.4876863 0.30242608 0.30108387 -2.1002711 0.13136667 0.13476667 0.11346667 -0.02130000 8.065122e-01 2.269671e-05 FALSE TRUE
ENST00000372243 ENSG00000126106 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM53 protein_coding protein_coding 8.933733 15.70838 4.193701 0.4742487 0.1940846 -1.902721 0.8068268 1.2018288 0.4587410 0.09848736 0.19744704 -1.3703231 0.09883750 0.07663333 0.11080000 0.03416667 8.510415e-01 2.269671e-05 FALSE TRUE
ENST00000372244 ENSG00000126106 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM53 protein_coding protein_coding 8.933733 15.70838 4.193701 0.4742487 0.1940846 -1.902721 0.5911425 1.4680223 0.2979278 0.10524827 0.06557832 -2.2630042 0.06094583 0.09373333 0.07283333 -0.02090000 6.700217e-01 2.269671e-05 FALSE FALSE
ENST00000420706 ENSG00000126106 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM53 protein_coding protein_coding 8.933733 15.70838 4.193701 0.4742487 0.1940846 -1.902721 0.6051104 0.5005197 0.7481540 0.05967389 0.17030396 0.5705242 0.07248333 0.03213333 0.17870000 0.14656667 2.269671e-05 2.269671e-05 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000126106 E001 75.97488 0.0040283890 0.47806521 0.61651999 1 44635238 44636047 810 - 1.710 1.753 0.148
ENSG00000126106 E002 42.40917 0.0062470917 0.40766984 0.55125883 1 44636048 44636457 410 - 1.546 1.489 -0.196
ENSG00000126106 E003 18.27309 0.0010715620 0.43886578 0.58068484 1 44645360 44645464 105 - 1.214 1.138 -0.268
ENSG00000126106 E004 36.70842 0.0006657893 0.73136787 0.82304438 1 44653247 44654464 1218 - 1.450 1.426 -0.084
ENSG00000126106 E005 106.61051 0.0003445611 0.16273027 0.27871335 1 44654465 44654895 431 - 1.832 1.894 0.207
ENSG00000126106 E006 35.94668 0.0059503772 0.44417442 0.58574888 1 44654896 44654939 44 - 1.368 1.433 0.224
ENSG00000126106 E007 74.69195 0.0004409352 0.25886353 0.39618781 1 44654940 44655116 177 - 1.679 1.740 0.206
ENSG00000126106 E008 29.51640 0.0018448251 0.14116001 0.24962513 1 44655117 44655119 3 - 1.232 1.365 0.465
ENSG00000126106 E009 38.57740 0.0007036275 0.84517671 0.90368715 1 44655120 44655209 90 - 1.461 1.448 -0.046
ENSG00000126106 E010 75.95677 0.0003791442 0.03918201 0.08951899 1 44660174 44660295 122 - 1.823 1.725 -0.333
ENSG00000126106 E011 74.38017 0.0005047382 0.15262975 0.26525074 1 44674331 44674481 151 - 1.790 1.720 -0.238