ENSG00000126001

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000397527 ENSG00000126001 HEK293_OSMI2_2hA HEK293_TMG_2hB CEP250 protein_coding protein_coding 11.69535 10.71226 10.33407 1.31772 0.320917 -0.05180464 0.6672682 0.8833530 0.3926483 0.05851094 0.06139524 -1.1497101 0.05691667 0.08386667 0.03780000 -0.04606667 2.005882e-02 1.058127e-09 FALSE TRUE
ENST00000425096 ENSG00000126001 HEK293_OSMI2_2hA HEK293_TMG_2hB CEP250 protein_coding protein_coding 11.69535 10.71226 10.33407 1.31772 0.320917 -0.05180464 0.3964561 0.0000000 0.8711476 0.00000000 0.19456827 6.4613118 0.03505000 0.00000000 0.08346667 0.08346667 1.058127e-09 1.058127e-09 FALSE FALSE
ENST00000425525 ENSG00000126001 HEK293_OSMI2_2hA HEK293_TMG_2hB CEP250 protein_coding nonsense_mediated_decay 11.69535 10.71226 10.33407 1.31772 0.320917 -0.05180464 0.9328138 0.8458502 0.4860860 0.57537693 0.31331616 -0.7867680 0.07395417 0.07290000 0.04850000 -0.02440000 9.399953e-01 1.058127e-09 FALSE FALSE
ENST00000487467 ENSG00000126001 HEK293_OSMI2_2hA HEK293_TMG_2hB CEP250 protein_coding retained_intron 11.69535 10.71226 10.33407 1.31772 0.320917 -0.05180464 2.0887609 1.4734300 2.0309697 0.33067666 0.31202451 0.4603180 0.17220000 0.13410000 0.19560000 0.06150000 3.524056e-01 1.058127e-09   FALSE
MSTRG.20627.1 ENSG00000126001 HEK293_OSMI2_2hA HEK293_TMG_2hB CEP250 protein_coding   11.69535 10.71226 10.33407 1.31772 0.320917 -0.05180464 1.9479867 2.4183215 1.0868199 0.81625860 0.56879548 -1.1466329 0.16594583 0.24880000 0.10463333 -0.14416667 5.042649e-01 1.058127e-09 FALSE TRUE
MSTRG.20627.13 ENSG00000126001 HEK293_OSMI2_2hA HEK293_TMG_2hB CEP250 protein_coding   11.69535 10.71226 10.33407 1.31772 0.320917 -0.05180464 1.4241349 0.1782895 1.9481302 0.10910960 0.29905616 3.3784524 0.12695000 0.01480000 0.18736667 0.17256667 3.132080e-06 1.058127e-09 FALSE TRUE
MSTRG.20627.5 ENSG00000126001 HEK293_OSMI2_2hA HEK293_TMG_2hB CEP250 protein_coding   11.69535 10.71226 10.33407 1.31772 0.320917 -0.05180464 0.6132502 0.3701118 0.8950987 0.27309596 0.22665635 1.2516513 0.05551250 0.02956667 0.08796667 0.05840000 3.612495e-01 1.058127e-09 FALSE TRUE
MSTRG.20627.7 ENSG00000126001 HEK293_OSMI2_2hA HEK293_TMG_2hB CEP250 protein_coding   11.69535 10.71226 10.33407 1.31772 0.320917 -0.05180464 1.3268515 1.9122912 0.8062340 0.43133128 0.48873073 -1.2357723 0.11394167 0.17436667 0.07686667 -0.09750000 5.289022e-01 1.058127e-09 FALSE TRUE
MSTRG.20627.9 ENSG00000126001 HEK293_OSMI2_2hA HEK293_TMG_2hB CEP250 protein_coding   11.69535 10.71226 10.33407 1.31772 0.320917 -0.05180464 1.1837762 1.6709445 1.0437427 0.55539525 0.32014164 -0.6737495 0.10266250 0.14763333 0.10280000 -0.04483333 6.844691e-01 1.058127e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000126001 E001 0.1515154 0.0433275330 2.793517e-01   20 35455162 35455163 2 + 0.156 0.000 -9.754
ENSG00000126001 E002 0.2987644 0.0270695846 8.605791e-02   20 35455164 35455169 6 + 0.270 0.000 -13.439
ENSG00000126001 E003 0.7416549 0.0950858919 5.901210e-01 7.130479e-01 20 35455170 35455174 5 + 0.270 0.176 -0.789
ENSG00000126001 E004 1.3328410 0.0155969696 2.788852e-02 6.779496e-02 20 35455175 35455186 12 + 0.554 0.174 -2.389
ENSG00000126001 E005 4.3408378 0.1209027211 1.368541e-01 2.437099e-01 20 35455187 35455200 14 + 0.846 0.584 -1.084
ENSG00000126001 E006 11.0940586 0.0493044612 1.326674e-01 2.378094e-01 20 35455201 35455237 37 + 1.169 0.971 -0.718
ENSG00000126001 E007 8.2530905 0.1187526011 5.203306e-01 6.543100e-01 20 35455238 35455242 5 + 1.018 0.884 -0.500
ENSG00000126001 E008 13.5885037 0.0314528027 3.235632e-01 4.668836e-01 20 35455243 35455516 274 + 1.194 1.090 -0.374
ENSG00000126001 E009 3.9075270 0.0056071840 6.965605e-04 2.886608e-03 20 35455597 35455597 1 + 0.920 0.435 -2.085
ENSG00000126001 E010 4.0892313 0.0137844695 2.093805e-03 7.514587e-03 20 35455598 35455606 9 + 0.920 0.474 -1.889
ENSG00000126001 E011 8.8801706 0.0025444557 1.466473e-02 3.973611e-02 20 35455607 35455723 117 + 1.116 0.855 -0.969
ENSG00000126001 E012 7.6913287 0.0023325251 2.542063e-01 3.908564e-01 20 35455724 35455751 28 + 0.983 0.855 -0.484
ENSG00000126001 E013 18.5372670 0.0017235370 6.498327e-03 1.991859e-02 20 35458304 35458374 71 + 1.385 1.170 -0.753
ENSG00000126001 E014 36.4382923 0.0108882555 8.854216e-04 3.563033e-03 20 35459983 35460105 123 + 1.688 1.448 -0.823
ENSG00000126001 E015 72.5629259 0.0070498894 3.398287e-06 2.513647e-05 20 35462265 35462553 289 + 1.993 1.737 -0.862
ENSG00000126001 E016 32.6024659 0.0130005297 2.077743e-04 9.972327e-04 20 35463575 35463631 57 + 1.673 1.382 -0.994
ENSG00000126001 E017 27.2332995 0.0213881345 1.034889e-03 4.079074e-03 20 35465743 35465763 21 + 1.600 1.298 -1.039
ENSG00000126001 E018 40.9924253 0.0080086093 2.302362e-05 1.407245e-04 20 35465764 35465825 62 + 1.759 1.477 -0.960
ENSG00000126001 E019 63.9502905 0.0038960769 2.191256e-09 3.047698e-08 20 35466039 35466204 166 + 1.963 1.657 -1.033
ENSG00000126001 E020 45.0594260 0.0020654350 1.712194e-04 8.403153e-04 20 35466966 35467072 107 + 1.759 1.556 -0.690
ENSG00000126001 E021 0.9191074 0.0133211983 1.325947e-01 2.377002e-01 20 35467272 35467303 32 + 0.435 0.174 -1.808
ENSG00000126001 E022 78.0762990 0.0005157397 3.731275e-06 2.735455e-05 20 35467304 35467555 252 + 1.981 1.798 -0.616
ENSG00000126001 E023 0.0000000       20 35469846 35469889 44 +      
ENSG00000126001 E024 48.5427433 0.0034203387 2.384532e-02 5.949068e-02 20 35469890 35469986 97 + 1.739 1.616 -0.417
ENSG00000126001 E025 3.1239361 0.0052463289 8.045229e-01 8.756415e-01 20 35469987 35470132 146 + 0.604 0.569 -0.153
ENSG00000126001 E026 26.6602927 0.0234491711 1.468833e-02 3.978583e-02 20 35472050 35472052 3 + 1.549 1.325 -0.773
ENSG00000126001 E027 50.5475839 0.0004575929 1.096900e-05 7.220944e-05 20 35472053 35472151 99 + 1.811 1.598 -0.721
ENSG00000126001 E028 64.7672128 0.0009036229 3.244844e-04 1.478666e-03 20 35472673 35472831 159 + 1.888 1.730 -0.533
ENSG00000126001 E029 60.2018339 0.0027290229 3.225400e-03 1.093099e-02 20 35473374 35473552 179 + 1.850 1.705 -0.488
ENSG00000126001 E030 33.0184164 0.0012782383 1.461727e-02 3.963245e-02 20 35473870 35473954 85 + 1.595 1.448 -0.501
ENSG00000126001 E031 29.2743543 0.0007033136 2.077842e-05 1.283891e-04 20 35473955 35474000 46 + 1.609 1.341 -0.921
ENSG00000126001 E032 31.6643400 0.0065222780 3.041263e-02 7.277075e-02 20 35474001 35474052 52 + 1.575 1.423 -0.520
ENSG00000126001 E033 1.7285165 0.0081333665 6.721829e-02 1.387273e-01 20 35474794 35474852 59 + 0.603 0.297 -1.615
ENSG00000126001 E034 53.2656765 0.0112796548 4.160008e-02 9.400060e-02 20 35475502 35475646 145 + 1.793 1.652 -0.475
ENSG00000126001 E035 66.8341131 0.0131699600 1.313197e-02 3.621427e-02 20 35476449 35476595 147 + 1.906 1.737 -0.568
ENSG00000126001 E036 1.6052155 0.1903258491 1.126660e-01 2.094419e-01 20 35477868 35477870 3 + 0.602 0.243 -2.000
ENSG00000126001 E037 74.5298285 0.0078034514 5.872284e-02 1.244420e-01 20 35477871 35478101 231 + 1.909 1.809 -0.338
ENSG00000126001 E038 26.4546192 0.0190162256 1.955014e-01 3.205875e-01 20 35479231 35479245 15 + 1.475 1.366 -0.376
ENSG00000126001 E039 60.6042148 0.0100839314 9.561727e-03 2.768940e-02 20 35479246 35479424 179 + 1.858 1.699 -0.536
ENSG00000126001 E040 60.7413475 0.0005171148 2.559517e-05 1.548090e-04 20 35479646 35479773 128 + 1.875 1.688 -0.633
ENSG00000126001 E041 76.3784512 0.0003852204 1.598972e-05 1.014129e-04 20 35479976 35480145 170 + 1.965 1.794 -0.575
ENSG00000126001 E042 72.6071991 0.0003962165 5.429729e-01 6.736736e-01 20 35490637 35490804 168 + 1.844 1.824 -0.067
ENSG00000126001 E043 62.9955448 0.0057335629 6.550176e-01 7.650124e-01 20 35491212 35491346 135 + 1.787 1.767 -0.069
ENSG00000126001 E044 63.8139114 0.0071487544 1.820255e-01 3.037532e-01 20 35493429 35493572 144 + 1.831 1.756 -0.253
ENSG00000126001 E045 8.5436440 0.0020261175 2.731216e-03 9.467034e-03 20 35494378 35494523 146 + 1.143 0.823 -1.191
ENSG00000126001 E046 74.1255913 0.0005054746 7.729873e-02 1.551565e-01 20 35494524 35494657 134 + 1.890 1.821 -0.233
ENSG00000126001 E047 73.0898818 0.0004065444 7.399028e-02 1.498977e-01 20 35496577 35496715 139 + 1.883 1.813 -0.236
ENSG00000126001 E048 61.7827390 0.0004841866 8.375048e-01 8.984118e-01 20 35497719 35497808 90 + 1.765 1.762 -0.010
ENSG00000126001 E049 81.5470399 0.0057334892 4.964442e-01 6.331031e-01 20 35497809 35498067 259 + 1.904 1.876 -0.094
ENSG00000126001 E050 63.3229749 0.0012349861 3.833544e-01 5.275398e-01 20 35498595 35498716 122 + 1.799 1.764 -0.118
ENSG00000126001 E051 76.8406066 0.0034980631 2.168254e-01 3.465822e-01 20 35500049 35500169 121 + 1.897 1.843 -0.183
ENSG00000126001 E052 87.1478575 0.0003535064 7.087353e-01 8.063162e-01 20 35501845 35501966 122 + 1.918 1.910 -0.028
ENSG00000126001 E053 208.9266351 0.0015012791 4.906750e-01 6.280150e-01 20 35502390 35502905 516 + 2.297 2.285 -0.042
ENSG00000126001 E054 344.1306064 0.0005048601 4.587248e-02 1.018029e-01 20 35502906 35503664 759 + 2.467 2.519 0.173
ENSG00000126001 E055 410.5784160 0.0007420653 7.083876e-12 1.512134e-10 20 35503665 35504654 990 + 2.465 2.626 0.534
ENSG00000126001 E056 120.5891589 0.0013648702 2.310571e-05 1.411898e-04 20 35504655 35504802 148 + 1.925 2.099 0.585
ENSG00000126001 E057 151.7874361 0.0013556118 7.539589e-08 7.840337e-07 20 35504803 35505005 203 + 2.006 2.208 0.677
ENSG00000126001 E058 113.8804478 0.0048498506 2.688430e-07 2.512034e-06 20 35507738 35507851 114 + 1.831 2.101 0.908
ENSG00000126001 E059 152.1824651 0.0014643773 8.510809e-14 2.443691e-12 20 35508035 35508190 156 + 1.940 2.228 0.964
ENSG00000126001 E060 130.5055608 0.0032241960 2.104572e-11 4.156205e-10 20 35508943 35509044 102 + 1.852 2.165 1.048
ENSG00000126001 E061 101.4456387 0.0037224488 1.083549e-10 1.901928e-09 20 35509998 35510054 57 + 1.725 2.062 1.135
ENSG00000126001 E062 324.1720565 0.0039798623 2.518663e-09 3.467431e-08 20 35511363 35516981 5619 + 2.315 2.543 0.759
ENSG00000126001 E063 56.4207588 0.0142851247 6.357411e-03 1.955151e-02 20 35516982 35519280 2299 + 1.565 1.787 0.755