ENSG00000125970

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000442805 ENSG00000125970 HEK293_OSMI2_2hA HEK293_TMG_2hB RALY protein_coding protein_coding 170.6571 299.6427 98.23439 8.682737 1.486888 -1.608844 24.38519 46.31838 12.21018 5.465986 1.7988959 -1.922631 0.1404417 0.1543667 0.1244333 -0.02993333 0.63918502 0.001169743 FALSE  
MSTRG.20580.14 ENSG00000125970 HEK293_OSMI2_2hA HEK293_TMG_2hB RALY protein_coding   170.6571 299.6427 98.23439 8.682737 1.486888 -1.608844 40.52701 80.72226 19.42106 2.379817 0.9236475 -2.054780 0.2231708 0.2702000 0.1978000 -0.07240000 0.02449154 0.001169743 FALSE  
MSTRG.20580.7 ENSG00000125970 HEK293_OSMI2_2hA HEK293_TMG_2hB RALY protein_coding   170.6571 299.6427 98.23439 8.682737 1.486888 -1.608844 88.99847 151.78157 56.80593 7.146770 2.5661572 -1.417724 0.5300542 0.5061667 0.5777667 0.07160000 0.11896016 0.001169743 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000125970 E001 4.0397457 7.114008e-02 2.530379e-01 3.895059e-01 20 33993577 33993645 69 + 0.775 0.573 -0.853
ENSG00000125970 E002 16.1740304 1.151328e-03 3.253259e-02 7.686708e-02 20 33993646 33993679 34 + 1.291 1.090 -0.717
ENSG00000125970 E003 49.9060184 1.716181e-02 1.249767e-04 6.365665e-04 20 33993680 33993801 122 + 1.836 1.521 -1.068
ENSG00000125970 E004 85.0900758 2.918564e-02 4.430580e-03 1.434632e-02 20 33993802 33993901 100 + 2.021 1.765 -0.863
ENSG00000125970 E005 51.0361156 4.964905e-02 6.015880e-03 1.865379e-02 20 33993902 33993910 9 + 1.839 1.529 -1.054
ENSG00000125970 E006 202.1437947 1.656876e-02 2.971445e-03 1.017812e-02 20 33993911 33993952 42 + 2.352 2.153 -0.664
ENSG00000125970 E007 971.5633123 3.204916e-03 8.341983e-07 7.047644e-06 20 33993953 33994131 179 + 2.993 2.847 -0.485
ENSG00000125970 E008 1.5780558 8.976064e-03 4.103503e-01 5.539536e-01 20 34029861 34029927 67 + 0.209 0.375 1.146
ENSG00000125970 E009 1220.6748448 1.254246e-03 2.728758e-07 2.545949e-06 20 34031522 34031604 83 + 3.061 2.957 -0.347
ENSG00000125970 E010 1.5082147 1.035198e-02 1.346379e-01 2.406026e-01 20 34033164 34033239 76 + 0.541 0.269 -1.531
ENSG00000125970 E011 6.4041814 4.585711e-03 1.966013e-01 3.219897e-01 20 34059193 34059466 274 + 0.926 0.749 -0.686
ENSG00000125970 E012 33.7072859 1.390078e-03 2.593383e-02 6.381046e-02 20 34065044 34065160 117 + 1.560 1.403 -0.538
ENSG00000125970 E013 2060.9849169 9.115158e-04 1.041838e-03 4.103704e-03 20 34072066 34072205 140 + 3.249 3.195 -0.178
ENSG00000125970 E014 2065.7659790 4.876211e-04 9.220663e-01 9.548268e-01 20 34072206 34072330 125 + 3.207 3.205 -0.007
ENSG00000125970 E015 1479.3027214 5.021982e-04 4.385875e-01 5.804621e-01 20 34073563 34073609 47 + 3.051 3.062 0.037
ENSG00000125970 E016 1135.4136686 1.049084e-04 6.491884e-02 1.348998e-01 20 34073610 34073635 26 + 2.925 2.949 0.080
ENSG00000125970 E017 1006.4679143 1.392451e-03 5.001882e-01 6.364524e-01 20 34073819 34073866 48 + 2.906 2.890 -0.051
ENSG00000125970 E018 2378.9334866 9.432839e-05 3.106184e-04 1.422734e-03 20 34075874 34076040 167 + 3.239 3.272 0.112
ENSG00000125970 E019 3.7891149 4.276689e-03 5.447149e-01 6.751276e-01 20 34076041 34076229 189 + 0.673 0.573 -0.438
ENSG00000125970 E020 2.3175351 6.413382e-03 2.373693e-01 3.711315e-01 20 34076696 34076701 6 + 0.612 0.405 -1.006
ENSG00000125970 E021 1791.0619516 4.178837e-04 2.218692e-03 7.901878e-03 20 34076702 34076815 114 + 3.109 3.151 0.138
ENSG00000125970 E022 2115.5545252 2.738596e-04 1.697028e-03 6.273722e-03 20 34077028 34077212 185 + 3.186 3.223 0.122
ENSG00000125970 E023 1139.9150593 4.860895e-03 4.385065e-01 5.803873e-01 20 34077213 34077245 33 + 2.926 2.954 0.092
ENSG00000125970 E024 18.2196948 1.373579e-02 7.141309e-02 1.456787e-01 20 34077246 34077680 435 + 1.331 1.145 -0.657
ENSG00000125970 E025 1290.3769007 5.120737e-03 2.979728e-02 7.156567e-02 20 34078505 34078553 49 + 2.936 3.016 0.265
ENSG00000125970 E026 2096.4308530 3.204372e-03 1.341129e-04 6.772205e-04 20 34079910 34081183 1274 + 3.124 3.231 0.354
ENSG00000125970 E027 214.8968276 1.194816e-03 1.260374e-12 3.043868e-11 20 34081184 34084660 3477 + 2.401 2.176 -0.751
ENSG00000125970 E028 29.8355373 4.855575e-03 6.441187e-01 7.564852e-01 20 34084661 34084884 224 + 1.421 1.383 -0.130
ENSG00000125970 E029 0.4031496 2.518095e-02 9.413930e-01 9.671614e-01 20 34108164 34108167 4 + 0.000 0.128 8.434
ENSG00000125970 E030 0.6265839 4.701678e-02 3.725868e-01 5.170338e-01 20 34108168 34108308 141 + 0.001 0.225 9.152