ENSG00000125952

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000358402 ENSG00000125952 HEK293_OSMI2_2hA HEK293_TMG_2hB MAX protein_coding protein_coding 66.10373 94.07809 57.47412 2.911592 1.481499 -0.7108487 48.66681 76.05323 38.14148 2.461035 1.3264109 -0.9954604 0.7200125 0.8084333 0.6636333 -0.1448 6.094896e-08 9.900181e-09 FALSE TRUE
ENST00000358664 ENSG00000125952 HEK293_OSMI2_2hA HEK293_TMG_2hB MAX protein_coding protein_coding 66.10373 94.07809 57.47412 2.911592 1.481499 -0.7108487 13.00726 14.31774 16.35446 0.997622 0.7290293 0.1917554 0.2076375 0.1522000 0.2844000 0.1322 9.900181e-09 9.900181e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000125952 E001 0.9619818 0.0204040094 5.168021e-01 6.513242e-01 14 65006174 65006284 111 - 0.353 0.246 -0.722
ENSG00000125952 E002 6.9738063 0.0157080623 6.527367e-04 2.725448e-03 14 65060918 65062002 1085 - 1.118 0.702 -1.585
ENSG00000125952 E003 0.1472490 0.0428961624 2.919815e-01   14 65065537 65065602 66 - 0.152 0.000 -11.131
ENSG00000125952 E004 4.7431320 0.0787113778 8.397332e-01 8.998946e-01 14 65069694 65070369 676 - 0.749 0.726 -0.090
ENSG00000125952 E005 0.0000000       14 65075124 65075126 3 -      
ENSG00000125952 E006 13.4714148 0.0294074260 5.790080e-02 1.230335e-01 14 65075127 65075157 31 - 0.951 1.222 0.980
ENSG00000125952 E007 151.1991684 0.0024062190 9.153234e-07 7.660644e-06 14 65075158 65075201 44 - 2.009 2.222 0.714
ENSG00000125952 E008 2279.9726386 0.0003549136 1.393444e-35 3.533919e-33 14 65075202 65076085 884 - 3.243 3.374 0.434
ENSG00000125952 E009 1010.1432782 0.0023702799 2.025694e-02 5.202277e-02 14 65076086 65076457 372 - 2.933 3.002 0.228
ENSG00000125952 E010 291.7805209 0.0002113554 2.620332e-02 6.436154e-02 14 65076458 65076461 4 - 2.465 2.435 -0.101
ENSG00000125952 E011 673.4829824 0.0001070745 7.775524e-04 3.178444e-03 14 65076462 65076608 147 - 2.825 2.795 -0.098
ENSG00000125952 E012 482.9651740 0.0001764145 1.587691e-07 1.551469e-06 14 65076609 65076663 55 - 2.708 2.637 -0.235
ENSG00000125952 E013 22.8053173 0.0100059435 3.879786e-01 5.320904e-01 14 65076664 65077192 529 - 1.395 1.340 -0.190
ENSG00000125952 E014 3.4140038 0.0237210997 2.447769e-01 3.797747e-01 14 65077193 65077286 94 - 0.490 0.702 0.949
ENSG00000125952 E015 1.6135448 0.0507394218 6.765216e-01 7.814700e-01 14 65077287 65077300 14 - 0.353 0.441 0.494
ENSG00000125952 E016 2.0366544 0.0102005576 6.665877e-01 7.740161e-01 14 65077301 65077327 27 - 0.427 0.515 0.445
ENSG00000125952 E017 3.5104017 0.0098252079 2.181351e-01 3.481704e-01 14 65077328 65077343 16 - 0.748 0.578 -0.723
ENSG00000125952 E018 4.4723705 0.0245391442 1.849707e-01 3.074493e-01 14 65077344 65077384 41 - 0.836 0.656 -0.728
ENSG00000125952 E019 5.5366505 0.0053973478 4.035001e-02 9.166463e-02 14 65077385 65077428 44 - 0.951 0.703 -0.970
ENSG00000125952 E020 5.9451238 0.0028387250 1.465992e-01 2.570638e-01 14 65077429 65077562 134 - 0.930 0.764 -0.643
ENSG00000125952 E021 4.5233128 0.0063508967 1.097372e-01 2.051733e-01 14 65077563 65077643 81 - 0.861 0.657 -0.823
ENSG00000125952 E022 6.0439854 0.0379502576 1.676858e-01 2.851821e-01 14 65077644 65077773 130 - 0.951 0.761 -0.733
ENSG00000125952 E023 6.2216494 0.0026678788 3.229677e-01 4.663262e-01 14 65077774 65077912 139 - 0.909 0.801 -0.416
ENSG00000125952 E024 631.8368669 0.0004466491 2.368552e-12 5.467468e-11 14 65077913 65078036 124 - 2.841 2.743 -0.328
ENSG00000125952 E025 15.0785306 0.0012085186 1.830978e-01 3.050829e-01 14 65083744 65083993 250 - 1.089 1.230 0.501
ENSG00000125952 E026 33.8861035 0.0006180552 3.625459e-01 5.069585e-01 14 65083994 65084299 306 - 1.468 1.544 0.258
ENSG00000125952 E027 0.1817044 0.0394578542 7.854462e-01   14 65093498 65093702 205 - 0.000 0.098 9.620
ENSG00000125952 E028 0.9222279 0.0132501018 5.125721e-01 6.474633e-01 14 65093703 65093707 5 - 0.353 0.245 -0.722
ENSG00000125952 E029 531.4689492 0.0007014153 4.988676e-13 1.284962e-11 14 65093708 65093815 108 - 2.779 2.658 -0.405
ENSG00000125952 E030 138.7971852 0.0004851815 3.647559e-15 1.280139e-13 14 65101546 65101572 27 - 2.259 2.030 -0.765
ENSG00000125952 E031 0.8793535 0.1530367596 1.931378e-01 3.177071e-01 14 65101573 65101685 113 - 0.426 0.176 -1.741
ENSG00000125952 E032 384.2881668 0.0057270674 4.054861e-02 9.202641e-02 14 65102304 65102508 205 - 2.605 2.536 -0.230
ENSG00000125952 E033 14.4108536 0.0039551020 6.224833e-02 1.304206e-01 14 65102509 65102695 187 - 1.258 1.103 -0.554