ENSG00000125944

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000374612 ENSG00000125944 HEK293_OSMI2_2hA HEK293_TMG_2hB HNRNPR protein_coding protein_coding 152.431 86.72338 231.0502 7.754008 7.343006 1.41361 67.873172 38.983203 102.77125 2.1071332 4.3578159 1.398283 0.45517917 0.45253333 0.4445000 -0.008033333 9.343513e-01 3.045034e-27 FALSE TRUE
ENST00000374616 ENSG00000125944 HEK293_OSMI2_2hA HEK293_TMG_2hB HNRNPR protein_coding protein_coding 152.431 86.72338 231.0502 7.754008 7.343006 1.41361 30.989928 14.829641 47.13226 1.0203456 0.6152865 1.667565 0.20255833 0.17283333 0.2042667 0.031433333 3.892735e-01 3.045034e-27 FALSE TRUE
ENST00000476660 ENSG00000125944 HEK293_OSMI2_2hA HEK293_TMG_2hB HNRNPR protein_coding processed_transcript 152.431 86.72338 231.0502 7.754008 7.343006 1.41361 4.438356 17.630944 0.00000 5.6503600 0.0000000 -10.784712 0.05611667 0.19480000 0.0000000 -0.194800000 3.045034e-27 3.045034e-27 FALSE TRUE
ENST00000606561 ENSG00000125944 HEK293_OSMI2_2hA HEK293_TMG_2hB HNRNPR protein_coding protein_coding 152.431 86.72338 231.0502 7.754008 7.343006 1.41361 25.076044 7.879036 40.83946 0.6018972 1.9533599 2.372396 0.15317500 0.09356667 0.1771000 0.083533333 1.120091e-02 3.045034e-27 FALSE TRUE
MSTRG.535.2 ENSG00000125944 HEK293_OSMI2_2hA HEK293_TMG_2hB HNRNPR protein_coding   152.431 86.72338 231.0502 7.754008 7.343006 1.41361 14.114602 5.233492 26.57545 0.3132835 4.3762269 2.342037 0.07847917 0.06126667 0.1149667 0.053700000 7.323167e-02 3.045034e-27 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000125944 E001 5.3184527 3.717200e-03 3.987627e-02 9.080509e-02 1 23303771 23303923 153 - 0.673 0.965 1.150
ENSG00000125944 E002 4.5059971 3.582633e-03 1.522036e-01 2.646825e-01 1 23303924 23303962 39 - 0.633 0.856 0.907
ENSG00000125944 E003 9.3536106 1.851822e-03 5.112595e-01 6.463214e-01 1 23303963 23304106 144 - 0.956 1.053 0.359
ENSG00000125944 E004 48.4491840 5.494999e-04 1.452369e-01 2.551578e-01 1 23304688 23306411 1724 - 1.684 1.630 -0.184
ENSG00000125944 E005 10.9167375 1.773663e-02 1.278280e-01 2.311519e-01 1 23306412 23306503 92 - 1.091 0.917 -0.642
ENSG00000125944 E006 113.4372542 2.520377e-04 2.508269e-28 3.655262e-26 1 23306504 23309782 3279 - 2.132 1.689 -1.489
ENSG00000125944 E007 2.2518441 6.971578e-03 3.967897e-03 1.305249e-02 1 23309783 23309783 1 - 0.261 0.751 2.493
ENSG00000125944 E008 2.7667683 5.746056e-03 1.576251e-03 5.882088e-03 1 23309784 23309785 2 - 0.307 0.824 2.460
ENSG00000125944 E009 457.7735324 1.922470e-03 1.939174e-54 1.569960e-51 1 23309786 23309929 144 - 2.436 2.883 1.489
ENSG00000125944 E010 2245.8101031 2.936235e-03 3.558387e-16 1.425816e-14 1 23309930 23310332 403 - 3.235 3.465 0.766
ENSG00000125944 E011 1321.8078556 1.693952e-03 1.429260e-08 1.711886e-07 1 23310333 23310453 121 - 3.039 3.189 0.498
ENSG00000125944 E012 1886.8740507 6.762181e-04 2.128659e-02 5.419032e-02 1 23310454 23310827 374 - 3.229 3.288 0.199
ENSG00000125944 E013 1197.0243294 6.137471e-04 8.080744e-02 1.608043e-01 1 23310828 23311066 239 - 3.033 3.087 0.177
ENSG00000125944 E014 1161.3262641 7.189395e-05 7.872932e-02 1.574794e-01 1 23311201 23311322 122 - 3.023 3.070 0.155
ENSG00000125944 E015 0.0000000       1 23311662 23311893 232 -      
ENSG00000125944 E016 850.9604884 5.787558e-04 6.108593e-01 7.301153e-01 1 23313553 23313598 46 - 2.898 2.915 0.057
ENSG00000125944 E017 1082.5069327 9.223173e-04 3.172934e-01 4.601533e-01 1 23313599 23313702 104 - 3.006 3.012 0.018
ENSG00000125944 E018 1521.6901506 1.206233e-03 3.698666e-06 2.714108e-05 1 23318483 23318688 206 - 3.175 3.110 -0.215
ENSG00000125944 E019 76.7138184 3.523087e-04 3.347680e-02 7.872491e-02 1 23318689 23318697 9 - 1.886 1.818 -0.228
ENSG00000125944 E020 1169.9466978 2.342732e-03 5.260572e-07 4.632761e-06 1 23321528 23321663 136 - 3.073 2.965 -0.357
ENSG00000125944 E021 1208.4128117 2.410667e-04 6.013911e-15 2.046188e-13 1 23323556 23323732 177 - 3.079 3.002 -0.254
ENSG00000125944 E022 983.9042782 3.165188e-04 1.365023e-09 1.972987e-08 1 23333518 23333631 114 - 2.986 2.922 -0.212
ENSG00000125944 E023 1086.8052833 1.216579e-03 6.683275e-07 5.763504e-06 1 23337754 23337861 108 - 3.033 2.955 -0.259
ENSG00000125944 E024 1.5605418 1.010483e-02 5.066597e-01 6.423135e-01 1 23338063 23338163 101 - 0.349 0.485 0.735
ENSG00000125944 E025 0.2903454 3.094970e-01 6.651494e-01   1 23338270 23338489 220 - 0.149 0.000 -8.974
ENSG00000125944 E026 956.9118814 4.358962e-03 1.648413e-06 1.305547e-05 1 23338490 23338608 119 - 2.995 2.851 -0.477
ENSG00000125944 E027 333.4242007 1.529677e-04 4.206970e-30 7.173698e-28 1 23340852 23341017 166 - 2.560 2.323 -0.791
ENSG00000125944 E028 70.0040840 3.932316e-04 2.733187e-09 3.742098e-08 1 23341018 23341020 3 - 1.895 1.625 -0.914
ENSG00000125944 E029 481.7034530 4.017228e-03 2.419378e-09 3.339481e-08 1 23344211 23344400 190 - 2.710 2.514 -0.653