ENSG00000125912

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000246117 ENSG00000125912 HEK293_OSMI2_2hA HEK293_TMG_2hB NCLN protein_coding protein_coding 110.0301 161.9004 68.26762 9.93813 2.162325 -1.245711 65.054999 93.441837 43.059082 8.9547161 0.8729736 -1.117570 0.59282917 0.5753667 0.6318000 0.05643333 5.423754e-01 1.420332e-05 FALSE TRUE
ENST00000592737 ENSG00000125912 HEK293_OSMI2_2hA HEK293_TMG_2hB NCLN protein_coding protein_coding 110.0301 161.9004 68.26762 9.93813 2.162325 -1.245711 33.582153 62.897365 12.138124 5.3129986 1.1669229 -2.372495 0.28387500 0.3906000 0.1771333 -0.21346667 1.420332e-05 1.420332e-05 FALSE TRUE
MSTRG.16158.4 ENSG00000125912 HEK293_OSMI2_2hA HEK293_TMG_2hB NCLN protein_coding   110.0301 161.9004 68.26762 9.93813 2.162325 -1.245711 6.006028 1.996834 8.374807 0.9893699 1.1707076 2.062857 0.06678333 0.0119000 0.1218667 0.10996667 5.912707e-03 1.420332e-05 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000125912 E001 2.325012 7.312252e-03 2.520009e-02 6.228255e-02 19 3185563 3185718 156 + 0.703 0.354 -1.684
ENSG00000125912 E002 3.556613 3.561491e-02 6.876865e-03 2.090402e-02 19 3185719 3185914 196 + 0.880 0.460 -1.802
ENSG00000125912 E003 7.375078 2.280509e-03 1.419199e-04 7.117863e-04 19 3185915 3185929 15 + 1.135 0.715 -1.591
ENSG00000125912 E004 7.526593 2.275114e-03 6.997857e-05 3.799177e-04 19 3185930 3185935 6 + 1.150 0.715 -1.648
ENSG00000125912 E005 67.135554 3.645064e-02 2.689603e-05 1.618247e-04 19 3185936 3185956 21 + 2.024 1.636 -1.308
ENSG00000125912 E006 464.954959 9.518799e-03 7.547810e-04 3.096719e-03 19 3185957 3186214 258 + 2.702 2.570 -0.439
ENSG00000125912 E007 682.274067 5.297510e-03 9.794217e-03 2.825597e-02 19 3192470 3192660 191 + 2.819 2.757 -0.205
ENSG00000125912 E008 810.443948 2.599662e-03 6.236422e-05 3.430820e-04 19 3193284 3193428 145 + 2.905 2.827 -0.259
ENSG00000125912 E009 740.496741 4.656271e-04 3.428127e-09 4.603405e-08 19 3196183 3196277 95 + 2.860 2.787 -0.244
ENSG00000125912 E010 452.560235 4.094499e-04 1.131134e-05 7.423612e-05 19 3198817 3198840 24 + 2.639 2.577 -0.206
ENSG00000125912 E011 584.154076 2.793043e-04 9.858992e-03 2.841799e-02 19 3198841 3198897 57 + 2.717 2.699 -0.061
ENSG00000125912 E012 717.397699 7.200332e-04 4.881214e-05 2.757616e-04 19 3201523 3201626 104 + 2.829 2.781 -0.162
ENSG00000125912 E013 562.094370 3.018479e-03 2.433713e-02 6.051128e-02 19 3203756 3203796 41 + 2.719 2.679 -0.135
ENSG00000125912 E014 616.204458 1.979255e-03 4.128433e-02 9.340188e-02 19 3203797 3203844 48 + 2.747 2.723 -0.081
ENSG00000125912 E015 421.692343 2.548080e-03 2.331111e-01 3.661115e-01 19 3204005 3204014 10 + 2.570 2.563 -0.023
ENSG00000125912 E016 796.432094 2.600348e-03 3.405186e-01 4.844638e-01 19 3204015 3204144 130 + 2.838 2.842 0.013
ENSG00000125912 E017 1103.360972 8.529057e-04 4.431344e-03 1.434806e-02 19 3204573 3204751 179 + 2.996 2.976 -0.069
ENSG00000125912 E018 10.376990 2.200172e-02 3.069141e-01 4.490908e-01 19 3205832 3205938 107 + 1.065 0.965 -0.366
ENSG00000125912 E019 914.346000 2.238496e-04 3.557829e-05 2.076463e-04 19 3205939 3206026 88 + 2.921 2.890 -0.105
ENSG00000125912 E020 707.097108 9.930962e-05 1.035169e-01 1.958551e-01 19 3206152 3206190 39 + 2.784 2.787 0.009
ENSG00000125912 E021 247.497453 5.697679e-04 8.161254e-01 8.836566e-01 19 3206262 3206264 3 + 2.316 2.338 0.073
ENSG00000125912 E022 1215.238740 1.042600e-04 3.691562e-01 5.136012e-01 19 3206265 3206421 157 + 3.008 3.025 0.058
ENSG00000125912 E023 578.037892 1.740009e-04 2.801533e-03 9.679776e-03 19 3206422 3206425 4 + 2.716 2.692 -0.079
ENSG00000125912 E024 813.773617 9.427896e-05 3.050638e-04 1.400074e-03 19 3207198 3207251 54 + 2.865 2.841 -0.079
ENSG00000125912 E025 851.659886 1.272937e-04 1.779933e-01 2.986158e-01 19 3207391 3207465 75 + 2.860 2.869 0.029
ENSG00000125912 E026 517.443758 1.228235e-04 3.400996e-02 7.977965e-02 19 3207466 3207469 4 + 2.659 2.648 -0.034
ENSG00000125912 E027 2.713321 8.317337e-02 2.427668e-01 3.774369e-01 19 3207470 3207490 21 + 0.303 0.575 1.447
ENSG00000125912 E028 993.689161 3.044342e-04 5.533610e-01 6.825348e-01 19 3207629 3207747 119 + 2.919 2.939 0.068
ENSG00000125912 E029 5172.057986 1.285396e-03 1.442024e-16 6.087056e-15 19 3207748 3209234 1487 + 3.532 3.689 0.521
ENSG00000125912 E030 1557.694821 4.052045e-03 2.267610e-07 2.151832e-06 19 3209235 3209477 243 + 2.978 3.176 0.656
ENSG00000125912 E031 330.462737 1.889972e-03 1.948663e-10 3.270739e-09 19 3209478 3209575 98 + 2.274 2.510 0.786