ENSG00000125898

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000304189 ENSG00000125898 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM110A protein_coding protein_coding 4.311654 8.173923 2.166901 0.2986901 0.1887408 -1.910517 0.0827572 0.04700824 0.2042284 0.02392355 0.01777957 1.909907 0.0235500 0.005833333 0.09546667 0.08963333 1.540061e-06 1.540061e-06 FALSE  
ENST00000381941 ENSG00000125898 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM110A protein_coding protein_coding 4.311654 8.173923 2.166901 0.2986901 0.1887408 -1.910517 4.0639383 7.85180722 1.9203120 0.24403858 0.19145246 -2.026027 0.9394042 0.961033333 0.88483333 -0.07620000 1.963773e-02 1.540061e-06 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000125898 E001 14.1288526 0.0012951310 0.216805356 0.3465619 20 833715 833776 62 + 1.158 1.034 -0.450
ENSG00000125898 E002 13.7161511 0.0014163143 0.279970252 0.4197759 20 833777 833783 7 + 1.138 1.027 -0.400
ENSG00000125898 E003 36.8455406 0.0006831592 0.870226568 0.9205220 20 833784 833951 168 + 1.454 1.448 -0.022
ENSG00000125898 E004 0.7707125 0.0159932856 0.277980822 0.4176194 20 836068 836114 47 + 0.369 0.168 -1.500
ENSG00000125898 E005 2.2799724 0.0066550070 0.009506501 0.0275539 20 839455 839563 109 + 0.755 0.324 -2.083
ENSG00000125898 E006 0.0000000       20 841275 841316 42 +      
ENSG00000125898 E007 22.5043463 0.0164010203 0.886518470 0.9314211 20 844708 844710 3 + 1.232 1.257 0.087
ENSG00000125898 E008 87.7144802 0.0004735673 0.385366471 0.5295508 20 844711 845123 413 + 1.845 1.813 -0.107
ENSG00000125898 E009 112.9876002 0.0023657266 0.681534725 0.7851899 20 845124 845736 613 + 1.903 1.926 0.075
ENSG00000125898 E010 106.4487538 0.0044468274 0.046052904 0.1021363 20 845737 846279 543 + 1.815 1.916 0.339
ENSG00000125898 E011 2.1484290 0.1803034927 0.188166909 0.3114260 20 856749 857463 715 + 0.639 0.373 -1.303