ENSG00000125846

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000377671 ENSG00000125846 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF133 protein_coding protein_coding 8.143191 9.927102 6.340998 0.7199399 0.08504224 -0.645842 0.75614784 0.7374434 0.3150330 0.4022933 0.2174859 -1.2013781 0.09302917 0.07826667 0.05006667 -0.02820000 0.927334568 0.0006440185 FALSE TRUE
ENST00000425686 ENSG00000125846 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF133 protein_coding protein_coding 8.143191 9.927102 6.340998 0.7199399 0.08504224 -0.645842 0.09093354 0.0000000 0.3229891 0.0000000 0.3229891 5.0574030 0.01268333 0.00000000 0.05203333 0.05203333 0.773250851 0.0006440185 FALSE TRUE
ENST00000434018 ENSG00000125846 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF133 protein_coding protein_coding 8.143191 9.927102 6.340998 0.7199399 0.08504224 -0.645842 1.85877800 2.4986736 1.7612996 0.4101199 0.3528719 -0.5021165 0.23335000 0.26016667 0.27766667 0.01750000 0.954466361 0.0006440185 FALSE TRUE
ENST00000630056 ENSG00000125846 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF133 protein_coding protein_coding 8.143191 9.927102 6.340998 0.7199399 0.08504224 -0.645842 1.98693074 3.6265083 1.0790640 0.4551093 0.1873565 -1.7394652 0.22464583 0.36493333 0.17076667 -0.19416667 0.008736411 0.0006440185 FALSE TRUE
MSTRG.20413.11 ENSG00000125846 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF133 protein_coding   8.143191 9.927102 6.340998 0.7199399 0.08504224 -0.645842 0.56786333 0.4534224 0.7828789 0.3301041 0.1831196 0.7747727 0.07595833 0.04286667 0.12280000 0.07993333 0.356111213 0.0006440185 FALSE TRUE
MSTRG.20413.8 ENSG00000125846 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF133 protein_coding   8.143191 9.927102 6.340998 0.7199399 0.08504224 -0.645842 1.20152465 1.1761379 0.5673834 0.4555820 0.2818936 -1.0386702 0.15116667 0.11310000 0.08853333 -0.02456667 0.883484926 0.0006440185 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000125846 E001 0.2987644 0.0273463250 9.911623e-02   20 18288283 18288476 194 + 0.256 0.000 -10.210
ENSG00000125846 E002 0.0000000       20 18288477 18288499 23 +      
ENSG00000125846 E003 0.5106578 0.2658976469 9.168555e-01 9.514748e-01 20 18288500 18288504 5 + 0.146 0.185 0.406
ENSG00000125846 E004 0.6589510 0.0209796823 5.934501e-01 7.158465e-01 20 18288505 18288510 6 + 0.146 0.253 0.981
ENSG00000125846 E005 0.8041237 0.0155813886 9.222459e-01 9.549501e-01 20 18288511 18288526 16 + 0.256 0.253 -0.018
ENSG00000125846 E006 0.8041237 0.0155813886 9.222459e-01 9.549501e-01 20 18288527 18288528 2 + 0.256 0.253 -0.018
ENSG00000125846 E007 10.4067436 0.0320968950 3.821053e-01 5.263485e-01 20 18288529 18288559 31 + 1.087 1.003 -0.309
ENSG00000125846 E008 17.2916729 0.0051588832 1.154716e-01 2.135334e-01 20 18288560 18288604 45 + 1.306 1.199 -0.377
ENSG00000125846 E009 4.9944917 0.0490995192 1.903529e-01 3.142092e-01 20 18289899 18290074 176 + 0.869 0.675 -0.778
ENSG00000125846 E010 11.1485072 0.0052232789 3.666976e-04 1.645384e-03 20 18297985 18298062 78 + 1.251 0.924 -1.188
ENSG00000125846 E011 10.4051166 0.0016783005 2.684099e-05 1.615242e-04 20 18298289 18298464 176 + 1.251 0.865 -1.411
ENSG00000125846 E012 15.4889192 0.0013172304 7.432825e-01 8.319556e-01 20 18305008 18305178 171 + 1.165 1.226 0.216
ENSG00000125846 E013 11.1178055 0.0016367576 7.523613e-01 8.385834e-01 20 18305668 18305680 13 + 1.073 1.073 -0.001
ENSG00000125846 E014 39.5024265 0.0006148063 6.013553e-01 7.224844e-01 20 18305681 18305807 127 + 1.588 1.591 0.012
ENSG00000125846 E015 1.1145283 0.0323228284 7.813715e-01 8.595497e-01 20 18306271 18306297 27 + 0.343 0.312 -0.193
ENSG00000125846 E016 38.3767243 0.0005901043 5.355595e-01 6.673649e-01 20 18306298 18306393 96 + 1.579 1.576 -0.007
ENSG00000125846 E017 0.2934659 0.0288911815 7.166173e-01   20 18306706 18306747 42 + 0.146 0.102 -0.605
ENSG00000125846 E018 0.7427016 0.0156622657 3.776636e-03 1.251636e-02 20 18310169 18310306 138 + 0.478 0.000 -13.274
ENSG00000125846 E019 5.4260386 0.0036484560 7.364185e-05 3.976748e-04 20 18312636 18314767 2132 + 1.042 0.561 -1.925
ENSG00000125846 E020 12.6901393 0.0087410573 6.405730e-02 1.334506e-01 20 18315069 18315071 3 + 1.211 1.053 -0.564
ENSG00000125846 E021 439.4480959 0.0032683688 1.090595e-05 7.183182e-05 20 18315072 18316996 1925 + 2.567 2.655 0.293