ENSG00000125755

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000245934 ENSG00000125755 HEK293_OSMI2_2hA HEK293_TMG_2hB SYMPK protein_coding protein_coding 67.40541 108.3662 44.33107 3.877697 1.193277 -1.289332 15.225731 24.199277 9.8566263 3.596911 1.79302172 -1.2949312 0.21521250 0.2241333 0.220700000 -0.003433333 1.000000e+00 6.04518e-09 FALSE TRUE
ENST00000598155 ENSG00000125755 HEK293_OSMI2_2hA HEK293_TMG_2hB SYMPK protein_coding processed_transcript 67.40541 108.3662 44.33107 3.877697 1.193277 -1.289332 4.712163 14.752935 0.1763395 5.139835 0.09678262 -6.3079025 0.04834167 0.1361333 0.004033333 -0.132100000 8.788399e-04 6.04518e-09 FALSE TRUE
MSTRG.17344.10 ENSG00000125755 HEK293_OSMI2_2hA HEK293_TMG_2hB SYMPK protein_coding   67.40541 108.3662 44.33107 3.877697 1.193277 -1.289332 3.014031 4.412497 4.1112265 1.536206 1.32355934 -0.1017873 0.05005833 0.0409000 0.091300000 0.050400000 3.100002e-01 6.04518e-09 FALSE TRUE
MSTRG.17344.7 ENSG00000125755 HEK293_OSMI2_2hA HEK293_TMG_2hB SYMPK protein_coding   67.40541 108.3662 44.33107 3.877697 1.193277 -1.289332 23.750470 38.349863 14.3932669 1.571383 2.49635319 -1.4132015 0.35032500 0.3540333 0.328100000 -0.025933333 8.802483e-01 6.04518e-09 FALSE TRUE
MSTRG.17344.9 ENSG00000125755 HEK293_OSMI2_2hA HEK293_TMG_2hB SYMPK protein_coding   67.40541 108.3662 44.33107 3.877697 1.193277 -1.289332 5.590137 4.968198 6.4238208 0.765175 0.17763423 0.3700523 0.10205417 0.0457000 0.144900000 0.099200000 1.700269e-08 6.04518e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000125755 E001 0.0000000       19 45815410 45815427 18 -      
ENSG00000125755 E002 0.0000000       19 45815428 45815447 20 -      
ENSG00000125755 E003 0.5159433 0.2211718953 2.444430e-01 3.793953e-01 19 45815448 45815467 20 - 0.303 0.084 -2.240
ENSG00000125755 E004 0.6642364 0.0486511636 3.992475e-01 5.429957e-01 19 45815468 45815537 70 - 0.303 0.152 -1.262
ENSG00000125755 E005 0.8449217 0.1199705596 6.833526e-01 7.865651e-01 19 45815538 45815543 6 - 0.177 0.264 0.732
ENSG00000125755 E006 1.0663669 0.0152362977 4.832235e-01 6.212620e-01 19 45815544 45815544 1 - 0.177 0.312 1.060
ENSG00000125755 E007 540.1499232 0.0031609194 2.829682e-09 3.859986e-08 19 45815545 45815697 153 - 2.512 2.718 0.687
ENSG00000125755 E008 498.1809057 0.0043997245 9.450276e-09 1.171143e-07 19 45815851 45815895 45 - 2.459 2.687 0.759
ENSG00000125755 E009 1098.4100645 0.0041915728 1.137995e-14 3.712583e-13 19 45815896 45816183 288 - 2.767 3.037 0.899
ENSG00000125755 E010 312.6508150 0.0037445316 3.420160e-11 6.521745e-10 19 45816482 45816482 1 - 2.222 2.492 0.901
ENSG00000125755 E011 634.2050642 0.0034583299 2.415726e-14 7.504952e-13 19 45816483 45816577 95 - 2.532 2.798 0.887
ENSG00000125755 E012 11.0185818 0.0322691149 3.015021e-01 4.433130e-01 19 45816578 45816614 37 - 0.906 1.060 0.573
ENSG00000125755 E013 706.9077429 0.0033064916 1.411941e-10 2.429500e-09 19 45816798 45816974 177 - 2.621 2.837 0.719
ENSG00000125755 E014 7.6430010 0.0023925988 3.401047e-01 4.840567e-01 19 45816975 45817133 159 - 0.781 0.911 0.503
ENSG00000125755 E015 782.7507203 0.0016923351 1.265654e-08 1.531028e-07 19 45817959 45818146 188 - 2.719 2.868 0.496
ENSG00000125755 E016 9.1913076 0.0070606840 3.407432e-01 4.846813e-01 19 45818913 45818954 42 - 0.848 0.974 0.477
ENSG00000125755 E017 184.4937234 0.0075129549 1.390623e-01 2.467887e-01 19 45818955 45821383 2429 - 2.257 2.189 -0.228
ENSG00000125755 E018 650.4018218 0.0016246751 9.381724e-07 7.830034e-06 19 45821384 45821485 102 - 2.653 2.785 0.440
ENSG00000125755 E019 589.2518559 0.0013760706 1.049338e-05 6.943310e-05 19 45822756 45822846 91 - 2.622 2.738 0.387
ENSG00000125755 E020 596.4906807 0.0010950307 4.639474e-06 3.327785e-05 19 45823372 45823472 101 - 2.629 2.742 0.378
ENSG00000125755 E021 624.3005588 0.0007844400 3.480685e-06 2.569178e-05 19 45823767 45823875 109 - 2.655 2.760 0.350
ENSG00000125755 E022 12.5355429 0.0025343279 4.782754e-01 6.167070e-01 19 45823876 45824012 137 - 1.003 1.085 0.297
ENSG00000125755 E023 10.0119792 0.0018772353 8.517387e-01 9.080691e-01 19 45824044 45824161 118 - 0.957 0.983 0.096
ENSG00000125755 E024 681.0942061 0.0001114785 3.880188e-03 1.280712e-02 19 45825171 45825331 161 - 2.733 2.784 0.170
ENSG00000125755 E025 3.3517386 0.0056328998 1.417997e-01 2.505109e-01 19 45826215 45826225 11 - 0.743 0.520 -0.973
ENSG00000125755 E026 397.6790910 0.0001317584 1.133350e-01 2.103801e-01 19 45826226 45826280 55 - 2.510 2.548 0.125
ENSG00000125755 E027 481.8889553 0.0001268311 4.544111e-01 5.950483e-01 19 45826281 45826373 93 - 2.607 2.626 0.063
ENSG00000125755 E028 580.0799940 0.0002794432 3.340874e-01 4.778475e-01 19 45827510 45827623 114 - 2.710 2.698 -0.040
ENSG00000125755 E029 453.2325999 0.0003851471 7.476392e-01 8.350983e-01 19 45827837 45827918 82 - 2.584 2.597 0.041
ENSG00000125755 E030 50.2113095 0.0011844337 1.551862e-02 4.167019e-02 19 45827919 45828969 1051 - 1.740 1.612 -0.434
ENSG00000125755 E031 442.7943634 0.0012599549 6.206877e-01 7.377803e-01 19 45828970 45829054 85 - 2.590 2.584 -0.019
ENSG00000125755 E032 545.4287511 0.0007096030 9.777583e-01 9.901769e-01 19 45829055 45829205 151 - 2.671 2.677 0.019
ENSG00000125755 E033 559.2091622 0.0001401739 1.959722e-01 3.211704e-01 19 45830054 45830204 151 - 2.666 2.694 0.092
ENSG00000125755 E034 3.9743337 0.1148745480 4.312547e-02 9.677675e-02 19 45831170 45831383 214 - 0.878 0.504 -1.581
ENSG00000125755 E035 785.4867483 0.0001986800 6.376437e-02 1.329617e-01 19 45831384 45831588 205 - 2.850 2.827 -0.076
ENSG00000125755 E036 357.3503170 0.0002529626 2.819727e-07 2.624233e-06 19 45835078 45835095 18 - 2.567 2.462 -0.348
ENSG00000125755 E037 612.4310991 0.0011831599 3.699903e-06 2.714752e-05 19 45835096 45835228 133 - 2.796 2.700 -0.322
ENSG00000125755 E038 495.6515448 0.0015471202 1.581437e-04 7.834689e-04 19 45838461 45838554 94 - 2.699 2.610 -0.297
ENSG00000125755 E039 383.0627027 0.0011586643 7.574572e-06 5.172031e-05 19 45838555 45838592 38 - 2.600 2.492 -0.357
ENSG00000125755 E040 316.2319905 0.0006107750 1.985567e-04 9.576609e-04 19 45838593 45838615 23 - 2.500 2.415 -0.286
ENSG00000125755 E041 669.4664576 0.0011721944 2.702444e-04 1.258684e-03 19 45842250 45842489 240 - 2.818 2.745 -0.243
ENSG00000125755 E042 0.5117019 0.0242249911 3.294300e-01 4.729391e-01 19 45842490 45842708 219 - 0.001 0.212 9.061
ENSG00000125755 E043 0.3332198 0.0284764646 5.180929e-01   19 45842709 45843037 329 - 0.177 0.083 -1.263
ENSG00000125755 E044 0.3332198 0.0284764646 5.180929e-01   19 45843043 45843072 30 - 0.177 0.083 -1.263
ENSG00000125755 E045 509.7059505 0.0016257026 6.049780e-06 4.227482e-05 19 45844030 45844200 171 - 2.726 2.617 -0.362
ENSG00000125755 E046 634.2835655 0.0011444083 1.086011e-17 5.312200e-16 19 45847752 45848001 250 - 2.868 2.689 -0.596
ENSG00000125755 E047 266.3054219 0.0043719519 8.497509e-07 7.167532e-06 19 45848750 45848762 13 - 2.497 2.311 -0.620
ENSG00000125755 E048 357.1861103 0.0025713913 5.153618e-09 6.709301e-08 19 45848763 45848829 67 - 2.618 2.442 -0.587
ENSG00000125755 E049 305.1804984 0.0035993586 2.448317e-08 2.804949e-07 19 45848830 45848876 47 - 2.561 2.368 -0.644
ENSG00000125755 E050 396.0729434 0.0044086011 1.104432e-08 1.350800e-07 19 45852312 45852385 74 - 2.681 2.477 -0.679
ENSG00000125755 E051 364.8910231 0.0052381403 6.586682e-08 6.931988e-07 19 45852482 45852535 54 - 2.646 2.440 -0.688
ENSG00000125755 E052 254.4830192 0.0077644245 7.962618e-07 6.754552e-06 19 45854175 45854194 20 - 2.505 2.275 -0.766
ENSG00000125755 E053 302.9489966 0.0061744585 3.480428e-08 3.870373e-07 19 45854195 45854240 46 - 2.581 2.350 -0.770
ENSG00000125755 E054 1.3534901 0.0151100210 7.947033e-01 8.688578e-01 19 45854241 45854390 150 - 0.303 0.354 0.322
ENSG00000125755 E055 328.5176011 0.0096235470 1.286996e-04 6.532459e-04 19 45854391 45854497 107 - 2.589 2.402 -0.622
ENSG00000125755 E056 151.9518460 0.0071942598 1.994440e-03 7.209050e-03 19 45854498 45854507 10 - 2.230 2.080 -0.502
ENSG00000125755 E057 9.4625743 0.0023177646 7.576262e-02 1.527191e-01 19 45854508 45854585 78 - 0.781 1.011 0.875
ENSG00000125755 E058 9.7400293 0.0017464528 1.212802e-03 4.684522e-03 19 45854586 45854808 223 - 0.605 1.053 1.767
ENSG00000125755 E059 18.0557242 0.0024633353 1.905144e-01 3.144018e-01 19 45854809 45855807 999 - 1.117 1.246 0.458
ENSG00000125755 E060 13.3541550 0.0221740897 2.781968e-01 4.178345e-01 19 45861900 45862027 128 - 1.179 1.058 -0.436
ENSG00000125755 E061 3.7956717 0.0781792016 9.495115e-01 9.723974e-01 19 45862487 45862551 65 - 0.605 0.626 0.090
ENSG00000125755 E062 182.2572818 0.0080734795 8.119941e-05 4.336655e-04 19 45863058 45863194 137 - 2.338 2.144 -0.650