ENSG00000125740

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000353609 ENSG00000125740 HEK293_OSMI2_2hA HEK293_TMG_2hB FOSB protein_coding protein_coding 1.296546 2.349443 0.9919845 0.2820376 0.0968435 -1.235586 0.46492182 0.6499239 0.0000000 0.6499239 0.00000000 -6.0442278 0.34712083 0.2678000 0.00000000 -0.26780000 9.390423e-01 1.055622e-13 FALSE TRUE
ENST00000443841 ENSG00000125740 HEK293_OSMI2_2hA HEK293_TMG_2hB FOSB protein_coding protein_coding 1.296546 2.349443 0.9919845 0.2820376 0.0968435 -1.235586 0.02835641 0.2268513 0.0000000 0.2268513 0.00000000 -4.5659097 0.01552083 0.1241667 0.00000000 -0.12416667 9.184206e-01 1.055622e-13 FALSE TRUE
ENST00000586615 ENSG00000125740 HEK293_OSMI2_2hA HEK293_TMG_2hB FOSB protein_coding protein_coding 1.296546 2.349443 0.9919845 0.2820376 0.0968435 -1.235586 0.12061312 0.3656087 0.0322288 0.1831516 0.03222880 -3.1529313 0.10586667 0.1642333 0.03246667 -0.13176667 6.228073e-01 1.055622e-13 FALSE TRUE
ENST00000591858 ENSG00000125740 HEK293_OSMI2_2hA HEK293_TMG_2hB FOSB protein_coding protein_coding 1.296546 2.349443 0.9919845 0.2820376 0.0968435 -1.235586 0.11222051 0.4360932 0.1317629 0.4360932 0.13176293 -1.6538646 0.06520000 0.1560333 0.13280000 -0.02323333 9.558914e-01 1.055622e-13 FALSE TRUE
ENST00000592436 ENSG00000125740 HEK293_OSMI2_2hA HEK293_TMG_2hB FOSB protein_coding protein_coding 1.296546 2.349443 0.9919845 0.2820376 0.0968435 -1.235586 0.12249793 0.4843534 0.0000000 0.2532902 0.00000000 -5.6274708 0.07359167 0.2111000 0.00000000 -0.21110000 2.663687e-01 1.055622e-13 FALSE TRUE
ENST00000592811 ENSG00000125740 HEK293_OSMI2_2hA HEK293_TMG_2hB FOSB protein_coding protein_coding 1.296546 2.349443 0.9919845 0.2820376 0.0968435 -1.235586 0.27847164 0.1429145 0.2764876 0.1429145 0.14888925 0.9057478 0.23204583 0.0589000 0.27576667 0.21686667 4.588434e-01 1.055622e-13 FALSE TRUE
ENST00000615753 ENSG00000125740 HEK293_OSMI2_2hA HEK293_TMG_2hB FOSB protein_coding protein_coding 1.296546 2.349443 0.9919845 0.2820376 0.0968435 -1.235586 0.10132439 0.0000000 0.4813929 0.0000000 0.02272812 5.6188050 0.11518333 0.0000000 0.49536667 0.49536667 1.055622e-13 1.055622e-13 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000125740 E001 0.0000000       19 45467995 45467995 1 +      
ENSG00000125740 E002 12.7349583 0.0014505483 0.139534788 0.24738383 19 45467996 45468434 439 + 1.171 1.030 -0.507
ENSG00000125740 E003 13.8431929 0.0023339566 0.028671761 0.06935367 19 45468435 45468712 278 + 1.240 1.039 -0.720
ENSG00000125740 E004 1.7598368 0.0217647800 0.169648858 0.28774312 19 45469876 45469885 10 + 0.551 0.309 -1.300
ENSG00000125740 E005 1.9415412 0.0265191588 0.258335732 0.39557496 19 45469886 45469912 27 + 0.551 0.352 -1.035
ENSG00000125740 E006 5.5658044 0.0033674689 0.187489272 0.31056921 19 45469913 45470264 352 + 0.884 0.711 -0.686
ENSG00000125740 E007 3.7017677 0.0896538129 0.969689242 0.98502606 19 45470265 45470412 148 + 0.610 0.617 0.028
ENSG00000125740 E008 3.8122841 0.1399503343 0.583642455 0.70770259 19 45470413 45470628 216 + 0.708 0.609 -0.420
ENSG00000125740 E009 9.8407874 0.0019073508 0.125563901 0.22795201 19 45470629 45470745 117 + 1.089 0.927 -0.597
ENSG00000125740 E010 17.0381266 0.0012520805 0.239505177 0.37354006 19 45470746 45470949 204 + 1.253 1.154 -0.350
ENSG00000125740 E011 0.1451727 0.0429700250 0.192566239   19 45470950 45471078 129 + 0.180 0.000 -10.490
ENSG00000125740 E012 0.2924217 0.0274424043 0.048916557   19 45471079 45471193 115 + 0.306 0.000 -11.519
ENSG00000125740 E013 12.0181909 0.0018492030 0.894335036 0.93647071 19 45471194 45471301 108 + 1.031 1.047 0.061
ENSG00000125740 E014 1.4287184 0.0096765512 0.816860651 0.88416464 19 45471302 45472081 780 + 0.306 0.351 0.278
ENSG00000125740 E015 14.4931168 0.0093730963 0.847897666 0.90556406 19 45472551 45472706 156 + 1.106 1.130 0.084
ENSG00000125740 E016 9.2292078 0.1186279945 0.076133182 0.15332089 19 45472707 45472846 140 + 0.660 1.015 1.390
ENSG00000125740 E017 5.6618671 0.0032200970 0.102729763 0.19465738 19 45472847 45472847 1 + 0.552 0.805 1.072
ENSG00000125740 E018 113.4570422 0.0008973738 0.005794993 0.01807448 19 45472848 45475179 2332 + 1.927 2.009 0.275