ENSG00000125734

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000264080 ENSG00000125734 HEK293_OSMI2_2hA HEK293_TMG_2hB GPR108 protein_coding protein_coding 41.97183 61.71723 33.14564 1.834908 1.269128 -0.896653 13.517746 16.440350 11.5687632 1.7511581 1.4300181 -0.5066371 0.32168750 0.26546667 0.34800000 0.082533333 0.341498726 2.20895e-07 FALSE  
ENST00000430424 ENSG00000125734 HEK293_OSMI2_2hA HEK293_TMG_2hB GPR108 protein_coding protein_coding 41.97183 61.71723 33.14564 1.834908 1.269128 -0.896653 9.537791 17.033249 7.5745734 0.4779403 1.5481256 -1.1680604 0.21859167 0.27603333 0.23283333 -0.043200000 0.719304902 2.20895e-07 FALSE  
ENST00000537722 ENSG00000125734 HEK293_OSMI2_2hA HEK293_TMG_2hB GPR108 protein_coding processed_transcript 41.97183 61.71723 33.14564 1.834908 1.269128 -0.896653 2.850497 8.908502 0.5573089 2.2360880 0.3007052 -3.9745948 0.05458750 0.14563333 0.01676667 -0.128866667 0.103111977 2.20895e-07 FALSE  
ENST00000600773 ENSG00000125734 HEK293_OSMI2_2hA HEK293_TMG_2hB GPR108 protein_coding retained_intron 41.97183 61.71723 33.14564 1.834908 1.269128 -0.896653 4.570622 3.184349 4.1488022 0.5862206 0.6829316 0.3806464 0.12341667 0.05113333 0.12396667 0.072833333 0.005095148 2.20895e-07 FALSE  
MSTRG.16300.39 ENSG00000125734 HEK293_OSMI2_2hA HEK293_TMG_2hB GPR108 protein_coding   41.97183 61.71723 33.14564 1.834908 1.269128 -0.896653 3.126405 4.815260 2.5114807 1.0582040 0.7985418 -0.9363356 0.07859167 0.07906667 0.07433333 -0.004733333 0.967774858 2.20895e-07 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000125734 E001 2.877486 0.0055450126 3.891609e-01 5.332726e-01 19 6729914 6730054 141 - 0.643 0.503 -0.637
ENSG00000125734 E002 3.986627 0.0041451726 8.399934e-01 9.000805e-01 19 6730055 6730055 1 - 0.643 0.673 0.127
ENSG00000125734 E003 6.270748 0.0042794259 2.082029e-01 3.363310e-01 19 6730056 6730067 12 - 0.689 0.865 0.705
ENSG00000125734 E004 30.237915 0.0229981278 7.048493e-01 8.033135e-01 19 6730068 6730084 17 - 1.419 1.463 0.152
ENSG00000125734 E005 31.826556 0.0221351723 8.919330e-01 9.349942e-01 19 6730085 6730085 1 - 1.457 1.479 0.073
ENSG00000125734 E006 56.828698 0.0060738403 4.852610e-01 6.231666e-01 19 6730086 6730097 12 - 1.682 1.727 0.152
ENSG00000125734 E007 79.876832 0.0038999803 5.955494e-02 1.258562e-01 19 6730098 6730123 26 - 1.783 1.885 0.343
ENSG00000125734 E008 202.262268 0.0039166844 1.843085e-04 8.963111e-04 19 6730124 6730242 119 - 2.139 2.296 0.523
ENSG00000125734 E009 352.516228 0.0032677618 2.360586e-04 1.116898e-03 19 6730243 6730384 142 - 2.401 2.529 0.426
ENSG00000125734 E010 165.840368 0.0043964366 1.151997e-02 3.239547e-02 19 6730987 6730988 2 - 2.084 2.198 0.381
ENSG00000125734 E011 286.526055 0.0020750683 2.088011e-01 3.370777e-01 19 6730989 6731054 66 - 2.376 2.416 0.133
ENSG00000125734 E012 254.138276 0.0003227799 2.566329e-01 3.936133e-01 19 6731055 6731111 57 - 2.333 2.361 0.092
ENSG00000125734 E013 207.514674 0.0001961134 1.297992e-01 2.338815e-01 19 6731199 6731234 36 - 2.237 2.277 0.134
ENSG00000125734 E014 176.660092 0.0002698196 8.735570e-02 1.711245e-01 19 6731235 6731252 18 - 2.162 2.212 0.167
ENSG00000125734 E015 201.015957 0.0007674519 2.313392e-02 5.802838e-02 19 6731253 6731282 30 - 2.202 2.270 0.228
ENSG00000125734 E016 243.902429 0.0006354270 8.187119e-04 3.326267e-03 19 6731473 6731522 50 - 2.266 2.358 0.308
ENSG00000125734 E017 208.166135 0.0002338809 9.910094e-04 3.927611e-03 19 6731891 6731934 44 - 2.198 2.289 0.305
ENSG00000125734 E018 238.658193 0.0002550638 6.115684e-02 1.285774e-01 19 6732025 6732082 58 - 2.292 2.339 0.157
ENSG00000125734 E019 300.181646 0.0040512504 5.900900e-01 7.130252e-01 19 6732083 6732155 73 - 2.443 2.421 -0.072
ENSG00000125734 E020 353.625815 0.0001662261 1.042808e-01 1.970072e-01 19 6732263 6732380 118 - 2.522 2.487 -0.117
ENSG00000125734 E021 0.920137 0.0133550125 5.811860e-01 7.057719e-01 19 6732472 6732475 4 - 0.172 0.273 0.850
ENSG00000125734 E022 285.082285 0.0001596778 2.694599e-02 6.588163e-02 19 6732476 6732549 74 - 2.441 2.389 -0.173
ENSG00000125734 E023 22.818372 0.0031218142 6.931708e-07 5.957137e-06 19 6732550 6732773 224 - 1.561 1.182 -1.317
ENSG00000125734 E024 289.226898 0.0001958089 2.367639e-01 3.704449e-01 19 6732987 6733062 76 - 2.432 2.403 -0.096
ENSG00000125734 E025 199.198444 0.0002158647 5.460565e-01 6.763036e-01 19 6733168 6733189 22 - 2.239 2.254 0.051
ENSG00000125734 E026 224.666145 0.0001902173 1.297849e-01 2.338624e-01 19 6733190 6733233 44 - 2.331 2.291 -0.136
ENSG00000125734 E027 241.957638 0.0001974105 9.819422e-02 1.877780e-01 19 6733234 6733301 68 - 2.364 2.322 -0.143
ENSG00000125734 E028 302.024210 0.0033588491 2.338177e-02 5.854312e-02 19 6733570 6733674 105 - 2.485 2.406 -0.265
ENSG00000125734 E029 240.268539 0.0079349497 2.093940e-01 3.378103e-01 19 6733845 6733913 69 - 2.373 2.313 -0.201
ENSG00000125734 E030 16.964347 0.0010582604 5.913057e-05 3.271739e-04 19 6733935 6734004 70 - 1.419 1.084 -1.180
ENSG00000125734 E031 214.891013 0.0043266031 2.049713e-01 3.323705e-01 19 6734005 6734054 50 - 2.319 2.267 -0.173
ENSG00000125734 E032 286.389724 0.0038670111 3.286766e-01 4.721518e-01 19 6734183 6734307 125 - 2.432 2.396 -0.119
ENSG00000125734 E033 8.556507 0.0020194018 1.196039e-06 9.769583e-06 19 6735374 6735539 166 - 1.243 0.712 -1.991
ENSG00000125734 E034 15.836951 0.0011235263 9.620749e-02 1.846872e-01 19 6735540 6735621 82 - 1.278 1.129 -0.528
ENSG00000125734 E035 204.829095 0.0007406653 5.658551e-02 1.207336e-01 19 6735622 6735704 83 - 2.301 2.244 -0.191
ENSG00000125734 E036 143.981554 0.0011928932 2.204469e-01 3.509467e-01 19 6735908 6735958 51 - 2.139 2.094 -0.150
ENSG00000125734 E037 199.392323 0.0031278823 1.723780e-02 4.547228e-02 19 6736592 6736711 120 - 2.311 2.222 -0.299
ENSG00000125734 E038 9.771162 0.0021322189 1.611361e-02 4.298771e-02 19 6736712 6736989 278 - 1.149 0.891 -0.952
ENSG00000125734 E039 82.480079 0.0120115950 6.706873e-01 7.770634e-01 19 6736990 6737267 278 - 1.892 1.860 -0.107
ENSG00000125734 E040 13.632585 0.0266612130 8.881464e-02 1.733050e-01 19 6737268 6737456 189 - 1.243 1.042 -0.720
ENSG00000125734 E041 81.829715 0.0150798225 3.847919e-02 8.824635e-02 19 6737457 6737580 124 - 1.967 1.818 -0.502