ENSG00000125733

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000313285 ENSG00000125733 HEK293_OSMI2_2hA HEK293_TMG_2hB TRIP10 protein_coding protein_coding 23.38954 27.47254 23.46556 0.6847832 1.100589 -0.2273556 17.298249 21.9617438 14.849182 0.8092258 0.3100594 -0.5642947 0.7360542 0.7994 0.63640000 -0.16300000 0.01745681 0.0008860332 FALSE TRUE
ENST00000598843 ENSG00000125733 HEK293_OSMI2_2hA HEK293_TMG_2hB TRIP10 protein_coding retained_intron 23.38954 27.47254 23.46556 0.6847832 1.100589 -0.2273556 1.075293 0.2773624 2.268931 0.2773624 0.6527870 2.9874141 0.0455125 0.0101 0.09443333 0.08433333 0.05975174 0.0008860332   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000125733 E001 0.1515154 0.0431280619 3.299380e-01   19 6737925 6738270 346 + 0.147 0.000 -9.604
ENSG00000125733 E002 0.4375944 0.0260756250 3.788770e-02 8.713988e-02 19 6739032 6739288 257 + 0.343 0.000 -13.493
ENSG00000125733 E003 2.5327288 0.0154974041 2.409792e-02 6.001418e-02 19 6739680 6739713 34 + 0.734 0.365 -1.744
ENSG00000125733 E004 10.2238843 0.0021699344 4.538626e-02 1.009022e-01 19 6739714 6739726 13 + 1.154 0.950 -0.745
ENSG00000125733 E005 27.6926132 0.0058650663 2.580422e-01 3.952480e-01 19 6739727 6739761 35 + 1.487 1.400 -0.303
ENSG00000125733 E006 46.6775565 0.0005931927 1.154010e-01 2.134289e-01 19 6739762 6739785 24 + 1.709 1.627 -0.279
ENSG00000125733 E007 1.2136029 0.0108647759 5.457270e-01 6.760186e-01 19 6740683 6740908 226 + 0.256 0.365 0.715
ENSG00000125733 E008 1.4726265 0.0092870009 7.713284e-01 8.523788e-01 19 6740909 6740917 9 + 0.416 0.365 -0.286
ENSG00000125733 E009 3.8687260 0.0042252835 7.127987e-01 8.094128e-01 19 6740918 6740943 26 + 0.700 0.646 -0.229
ENSG00000125733 E010 5.3790170 0.0031230432 6.417552e-01 7.547200e-01 19 6740944 6741009 66 + 0.821 0.759 -0.245
ENSG00000125733 E011 128.4300875 0.0002555234 1.202800e-01 2.203826e-01 19 6741010 6741125 116 + 2.127 2.079 -0.163
ENSG00000125733 E012 6.0475133 0.0044548575 8.785561e-04 3.539164e-03 19 6741126 6741224 99 + 1.059 0.646 -1.609
ENSG00000125733 E013 129.1748947 0.0002335985 1.918789e-01 3.161249e-01 19 6741225 6741281 57 + 2.123 2.082 -0.136
ENSG00000125733 E014 214.5440591 0.0006641295 9.893323e-04 3.921949e-03 19 6742967 6743114 148 + 2.368 2.281 -0.291
ENSG00000125733 E015 123.9694824 0.0003025343 1.060837e-04 5.499917e-04 19 6743194 6743256 63 + 2.152 2.028 -0.416
ENSG00000125733 E016 3.1971052 0.0558768167 5.287739e-02 1.142754e-01 19 6743257 6743369 113 + 0.794 0.455 -1.495
ENSG00000125733 E017 4.4828200 0.0161713444 2.306731e-04 1.094533e-03 19 6743370 6743493 124 + 0.993 0.454 -2.259
ENSG00000125733 E018 167.1508930 0.0002067630 1.409016e-05 9.041249e-05 19 6743494 6743598 105 + 2.281 2.163 -0.394
ENSG00000125733 E019 176.6996217 0.0002543195 2.116058e-01 3.403901e-01 19 6743708 6743836 129 + 2.253 2.219 -0.112
ENSG00000125733 E020 0.1482932 0.0410879329 7.036228e-01   19 6743837 6743890 54 + 0.000 0.101 9.994
ENSG00000125733 E021 191.8806224 0.0001941866 4.777605e-01 6.162665e-01 19 6744554 6744700 147 + 2.256 2.274 0.062
ENSG00000125733 E022 224.4183756 0.0001919707 5.115232e-01 6.465227e-01 19 6744800 6744994 195 + 2.325 2.340 0.053
ENSG00000125733 E023 7.9401129 0.0021421352 1.489329e-02 4.024603e-02 19 6744995 6745200 206 + 1.088 0.815 -1.023
ENSG00000125733 E024 4.8617374 0.0032861507 8.277828e-02 1.638981e-01 19 6746029 6746078 50 + 0.581 0.832 1.043
ENSG00000125733 E025 10.2846649 0.0016386018 6.029891e-01 7.238597e-01 19 6746079 6746177 99 + 1.074 1.021 -0.194
ENSG00000125733 E026 8.7400945 0.0019565842 1.712662e-01 2.898298e-01 19 6746178 6746196 19 + 1.059 0.909 -0.553
ENSG00000125733 E027 7.0470418 0.0024052044 7.082636e-02 1.447234e-01 19 6746197 6746307 111 + 1.010 0.797 -0.809
ENSG00000125733 E028 11.4692524 0.0195695037 9.905984e-03 2.853193e-02 19 6746308 6746432 125 + 1.242 0.939 -1.098
ENSG00000125733 E029 5.2452636 0.0052670937 3.970600e-03 1.305980e-02 19 6746433 6746451 19 + 0.993 0.619 -1.485
ENSG00000125733 E030 186.8398072 0.0002195461 4.065324e-01 5.501560e-01 19 6746452 6746561 110 + 2.243 2.265 0.074
ENSG00000125733 E031 193.6862123 0.0004321495 6.135506e-01 7.322186e-01 19 6749934 6750066 133 + 2.265 2.279 0.046
ENSG00000125733 E032 214.4608855 0.0002040555 8.345499e-03 2.465543e-02 19 6750292 6750431 140 + 2.273 2.339 0.220
ENSG00000125733 E033 1.9196841 0.0077040030 4.719298e-01 6.110202e-01 19 6750432 6750511 80 + 0.533 0.412 -0.609
ENSG00000125733 E034 211.8718499 0.0008706841 2.358176e-06 1.805566e-05 19 6750512 6750633 122 + 2.219 2.353 0.446
ENSG00000125733 E035 11.0813584 0.0015457292 5.925405e-01 7.150730e-01 19 6751034 6751062 29 + 1.027 1.082 0.200
ENSG00000125733 E036 317.3283960 0.0001791626 1.341547e-15 4.993986e-14 19 6751063 6751530 468 + 2.370 2.536 0.554
ENSG00000125733 E037 1.5197542 0.0092083673 7.023539e-01 8.011877e-01 19 6752193 6752402 210 + 0.343 0.412 0.392