ENSG00000125726

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000245903 ENSG00000125726 HEK293_OSMI2_2hA HEK293_TMG_2hB CD70 protein_coding protein_coding 10.53859 15.57964 8.483931 0.3900335 0.3172266 -0.8760836 0.8072840 1.5167217 0.1154655 0.19864767 0.06114140 -3.605074420 0.067091667 0.09810000 0.01386667 -0.084233333 0.002650901 0.002650901 FALSE TRUE
ENST00000597430 ENSG00000125726 HEK293_OSMI2_2hA HEK293_TMG_2hB CD70 protein_coding protein_coding 10.53859 15.57964 8.483931 0.3900335 0.3172266 -0.8760836 0.6262905 1.0812623 0.2663035 0.04243192 0.15048186 -1.981672403 0.050512500 0.06943333 0.03180000 -0.037633333 0.474460844 0.002650901   TRUE
MSTRG.16293.1 ENSG00000125726 HEK293_OSMI2_2hA HEK293_TMG_2hB CD70 protein_coding   10.53859 15.57964 8.483931 0.3900335 0.3172266 -0.8760836 0.7165743 0.5684784 0.6478127 0.06668289 0.15256235 0.185413709 0.073350000 0.03633333 0.07666667 0.040333333 0.166112241 0.002650901 FALSE TRUE
MSTRG.16293.10 ENSG00000125726 HEK293_OSMI2_2hA HEK293_TMG_2hB CD70 protein_coding   10.53859 15.57964 8.483931 0.3900335 0.3172266 -0.8760836 0.9430662 1.7817729 0.3815140 1.20390922 0.38151398 -2.194252044 0.063608333 0.11193333 0.04403333 -0.067900000 0.607169109 0.002650901   FALSE
MSTRG.16293.3 ENSG00000125726 HEK293_OSMI2_2hA HEK293_TMG_2hB CD70 protein_coding   10.53859 15.57964 8.483931 0.3900335 0.3172266 -0.8760836 1.0147822 1.7290302 1.0745905 0.66665486 0.05245768 -0.681132520 0.096845833 0.11226667 0.12736667 0.015100000 0.828926401 0.002650901   FALSE
MSTRG.16293.4 ENSG00000125726 HEK293_OSMI2_2hA HEK293_TMG_2hB CD70 protein_coding   10.53859 15.57964 8.483931 0.3900335 0.3172266 -0.8760836 0.6514779 0.7559780 0.4048852 0.20751320 0.16751659 -0.884590851 0.062275000 0.04846667 0.04640000 -0.002066667 0.955891359 0.002650901 FALSE TRUE
MSTRG.16293.6 ENSG00000125726 HEK293_OSMI2_2hA HEK293_TMG_2hB CD70 protein_coding   10.53859 15.57964 8.483931 0.3900335 0.3172266 -0.8760836 3.0738293 4.1390624 2.5521654 0.83310430 0.25598978 -0.695421755 0.304112500 0.26480000 0.30283333 0.038033333 0.823742380 0.002650901   FALSE
MSTRG.16293.8 ENSG00000125726 HEK293_OSMI2_2hA HEK293_TMG_2hB CD70 protein_coding   10.53859 15.57964 8.483931 0.3900335 0.3172266 -0.8760836 2.5543737 3.0551938 3.0411947 0.34817450 0.29362733 -0.006604059 0.272420833 0.19750000 0.35700000 0.159500000 0.009601286 0.002650901   FALSE
MSTRG.16293.9 ENSG00000125726 HEK293_OSMI2_2hA HEK293_TMG_2hB CD70 protein_coding   10.53859 15.57964 8.483931 0.3900335 0.3172266 -0.8760836 0.1509083 0.9521445 0.0000000 0.95214454 0.00000000 -6.588181741 0.009791667 0.06116667 0.00000000 -0.061166667 0.899505599 0.002650901   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000125726 E001 0.4783925 0.0224279896 0.2327497971 0.3657077640 19 6583183 6583385 203 - 0.287 0.089 -2.049
ENSG00000125726 E002 0.4783925 0.0224279896 0.2327497971 0.3657077640 19 6583386 6583478 93 - 0.287 0.089 -2.050
ENSG00000125726 E003 6.1472435 0.0034979823 0.0028740797 0.0098952436 19 6585839 6585973 135 - 0.458 0.915 1.948
ENSG00000125726 E004 43.1290423 0.0025021928 0.2364914195 0.3701072254 19 6585974 6586153 180 - 1.558 1.626 0.233
ENSG00000125726 E005 70.7885800 0.0004360897 0.1430608834 0.2521932796 19 6586154 6586405 252 - 1.768 1.828 0.202
ENSG00000125726 E006 12.9342266 0.0015222973 0.2667692715 0.4050154524 19 6590103 6590136 34 - 1.016 1.128 0.410
ENSG00000125726 E007 19.2362725 0.0014669050 0.3594496032 0.5037814988 19 6590841 6591055 215 - 1.204 1.281 0.272
ENSG00000125726 E008 4.9766194 0.0035183184 0.2744743105 0.4136273472 19 6591056 6591150 95 - 0.631 0.792 0.665
ENSG00000125726 E009 23.9946134 0.0009308981 0.8687163390 0.9196177060 19 6592416 6592575 160 - 1.371 1.360 -0.036
ENSG00000125726 E010 21.3771937 0.0010234714 0.0001511727 0.0007522778 19 6593577 6593688 112 - 1.484 1.214 -0.940
ENSG00000125726 E011 23.4988066 0.0010112702 0.0958003527 0.1840883813 19 6593822 6594008 187 - 1.427 1.311 -0.405
ENSG00000125726 E012 2.6089247 0.0065224288 0.6755458669 0.7807904158 19 6594290 6594340 51 - 0.581 0.513 -0.314
ENSG00000125726 E013 3.2419360 0.0049508618 0.0344809671 0.0806782749 19 6602386 6602408 23 - 0.287 0.665 1.951
ENSG00000125726 E014 46.3084664 0.0006873318 0.1372139630 0.2442062046 19 6603941 6604103 163 - 1.680 1.606 -0.250