ENSG00000125676

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000245838 ENSG00000125676 HEK293_OSMI2_2hA HEK293_TMG_2hB THOC2 protein_coding protein_coding 36.04465 17.60288 54.56738 2.449271 0.4431053 1.631672 4.2074025 1.77242672 5.5295409 1.09561302 1.5423252 1.6359237 0.11120417 0.12153333 0.10090000 -0.02063333 0.914966764 1.178569e-09 FALSE TRUE
ENST00000438358 ENSG00000125676 HEK293_OSMI2_2hA HEK293_TMG_2hB THOC2 protein_coding protein_coding 36.04465 17.60288 54.56738 2.449271 0.4431053 1.631672 1.2157975 1.82525789 2.2258257 0.47782885 1.1255025 0.2848249 0.04929583 0.10046667 0.04083333 -0.05963333 0.614233168 1.178569e-09 FALSE TRUE
ENST00000441692 ENSG00000125676 HEK293_OSMI2_2hA HEK293_TMG_2hB THOC2 protein_coding protein_coding 36.04465 17.60288 54.56738 2.449271 0.4431053 1.631672 0.8193003 1.30369078 0.4596789 0.12163850 0.4596789 -1.4838790 0.04147083 0.07803333 0.00830000 -0.06973333 0.055046604 1.178569e-09 FALSE TRUE
ENST00000448128 ENSG00000125676 HEK293_OSMI2_2hA HEK293_TMG_2hB THOC2 protein_coding protein_coding 36.04465 17.60288 54.56738 2.449271 0.4431053 1.631672 3.8597816 5.76234348 4.3096045 1.60791595 1.0312171 -0.4182579 0.15198750 0.31470000 0.07930000 -0.23540000 0.000737901 1.178569e-09 FALSE TRUE
ENST00000464161 ENSG00000125676 HEK293_OSMI2_2hA HEK293_TMG_2hB THOC2 protein_coding retained_intron 36.04465 17.60288 54.56738 2.449271 0.4431053 1.631672 3.4130679 0.50987470 3.5987036 0.11724262 0.3663456 2.7952448 0.08871250 0.02980000 0.06606667 0.03626667 0.045792523 1.178569e-09 FALSE FALSE
ENST00000618150 ENSG00000125676 HEK293_OSMI2_2hA HEK293_TMG_2hB THOC2 protein_coding protein_coding 36.04465 17.60288 54.56738 2.449271 0.4431053 1.631672 2.9449178 2.27742876 3.4297321 0.40302835 0.4554304 0.5885694 0.09154583 0.12823333 0.06270000 -0.06553333 0.002213067 1.178569e-09 FALSE TRUE
MSTRG.34833.11 ENSG00000125676 HEK293_OSMI2_2hA HEK293_TMG_2hB THOC2 protein_coding   36.04465 17.60288 54.56738 2.449271 0.4431053 1.631672 2.4982464 0.04857463 4.3968122 0.04857463 0.5311715 6.2333157 0.05784167 0.00350000 0.08073333 0.07723333 0.001315661 1.178569e-09 TRUE TRUE
MSTRG.34833.12 ENSG00000125676 HEK293_OSMI2_2hA HEK293_TMG_2hB THOC2 protein_coding   36.04465 17.60288 54.56738 2.449271 0.4431053 1.631672 3.0926133 0.31410469 5.3504351 0.31410469 0.2449636 4.0478183 0.06152083 0.01413333 0.09810000 0.08396667 0.073634362 1.178569e-09 FALSE TRUE
MSTRG.34833.13 ENSG00000125676 HEK293_OSMI2_2hA HEK293_TMG_2hB THOC2 protein_coding   36.04465 17.60288 54.56738 2.449271 0.4431053 1.631672 3.9227228 1.50715401 8.4441994 1.03685217 0.5225551 2.4783006 0.09714167 0.07290000 0.15483333 0.08193333 0.533811372 1.178569e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000125676 E001 0.0000000       X 123600561 123600568 8 -      
ENSG00000125676 E002 59.8978020 0.0148786805 1.168049e-15 4.370599e-14 X 123600569 123600794 226 - 1.476 2.086 2.065
ENSG00000125676 E003 39.6870342 0.0168717327 2.149562e-09 2.994544e-08 X 123600795 123600799 5 - 1.358 1.868 1.741
ENSG00000125676 E004 63.0004388 0.0055397252 5.843409e-24 5.783784e-22 X 123600800 123600880 81 - 1.515 2.095 1.958
ENSG00000125676 E005 48.7211235 0.0009093522 5.383670e-30 9.074022e-28 X 123600881 123600942 62 - 1.395 1.992 2.030
ENSG00000125676 E006 123.6379660 0.0036063330 5.255777e-34 1.198184e-31 X 123600943 123601208 266 - 1.835 2.358 1.752
ENSG00000125676 E007 129.2478592 0.0002817865 9.128413e-29 1.376871e-26 X 123601209 123601338 130 - 1.925 2.294 1.236
ENSG00000125676 E008 23.8087908 0.0119130890 6.443178e-13 1.631873e-11 X 123601339 123601879 541 - 1.084 1.707 2.166
ENSG00000125676 E009 28.4096340 0.0142455158 1.769291e-12 4.162779e-11 X 123601880 123602099 220 - 1.166 1.775 2.098
ENSG00000125676 E010 47.0132460 0.0013620608 1.854147e-19 1.114765e-17 X 123602100 123602217 118 - 1.437 1.930 1.673
ENSG00000125676 E011 270.3683348 0.0004679152 1.849461e-25 2.119629e-23 X 123602218 123603372 1155 - 2.287 2.547 0.866
ENSG00000125676 E012 55.2287306 0.0006126500 6.675166e-02 1.379954e-01 X 123603373 123603448 76 - 1.660 1.759 0.335
ENSG00000125676 E013 108.9365784 0.0002809618 4.367874e-01 5.788197e-01 X 123603449 123603748 300 - 1.967 1.998 0.103
ENSG00000125676 E014 0.5117019 0.0327420990 4.685397e-03 1.505613e-02 X 123610198 123610293 96 - 0.000 0.459 13.814
ENSG00000125676 E015 82.7232712 0.0003081069 7.798976e-06 5.311092e-05 X 123610918 123610920 3 - 1.800 1.992 0.646
ENSG00000125676 E016 123.4703344 0.0002629217 1.650307e-06 1.306828e-05 X 123610921 123610957 37 - 1.980 2.151 0.571
ENSG00000125676 E017 80.1734706 0.0003468201 1.189840e-06 9.722724e-06 X 123610958 123610963 6 - 1.781 1.992 0.710
ENSG00000125676 E018 149.4074284 0.0008394236 2.794250e-05 1.673714e-04 X 123611440 123611499 60 - 2.071 2.217 0.489
ENSG00000125676 E019 108.4713967 0.0050987417 5.900015e-02 1.249250e-01 X 123611500 123611516 17 - 1.947 2.047 0.338
ENSG00000125676 E020 194.4691470 0.0001813888 1.775352e-03 6.520621e-03 X 123613399 123613529 131 - 2.200 2.291 0.304
ENSG00000125676 E021 122.2367063 0.0003955320 8.393819e-06 5.674972e-05 X 123613530 123613556 27 - 1.980 2.141 0.541
ENSG00000125676 E022 173.0924463 0.0002345506 4.818211e-07 4.274788e-06 X 123613639 123613708 70 - 2.131 2.284 0.511
ENSG00000125676 E023 245.4543910 0.0056778697 1.188067e-02 3.324506e-02 X 123614052 123614189 138 - 2.293 2.412 0.396
ENSG00000125676 E024 148.7371153 0.0030465694 4.897505e-03 1.564522e-02 X 123619401 123619436 36 - 2.077 2.197 0.401
ENSG00000125676 E025 30.8564864 0.0026178078 4.217052e-01 5.648320e-01 X 123619437 123619517 81 - 1.423 1.484 0.209
ENSG00000125676 E026 12.3425199 0.0063930964 2.619001e-01 3.996278e-01 X 123619518 123620092 575 - 1.096 0.961 -0.496
ENSG00000125676 E027 6.7642920 0.0028664900 4.981550e-01 6.346645e-01 X 123620093 123620187 95 - 0.806 0.898 0.353
ENSG00000125676 E028 16.3436419 0.0011661627 4.230416e-02 9.528016e-02 X 123620188 123620326 139 - 1.125 1.310 0.657
ENSG00000125676 E029 9.9932631 0.0233504439 7.151610e-01 8.111570e-01 X 123620327 123620374 48 - 0.983 0.935 -0.180
ENSG00000125676 E030 26.7373669 0.0007138383 9.539677e-01 9.751648e-01 X 123620375 123620906 532 - 1.380 1.384 0.015
ENSG00000125676 E031 156.5707787 0.0004560626 1.059731e-07 1.071535e-06 X 123620907 123620965 59 - 2.079 2.252 0.580
ENSG00000125676 E032 267.5946808 0.0020171439 2.213678e-04 1.055349e-03 X 123621157 123621474 318 - 2.329 2.450 0.403
ENSG00000125676 E033 70.6368029 0.0244351003 3.499518e-01 4.941435e-01 X 123621475 123621518 44 - 1.773 1.844 0.242
ENSG00000125676 E034 40.5045721 0.0545862137 3.894805e-01 5.335593e-01 X 123621519 123621522 4 - 1.533 1.618 0.288
ENSG00000125676 E035 75.5758075 0.0333838502 3.179326e-01 4.608403e-01 X 123621523 123621587 65 - 1.798 1.880 0.275
ENSG00000125676 E036 143.0282577 0.0046208982 3.664664e-02 8.480025e-02 X 123622758 123622860 103 - 2.067 2.165 0.329
ENSG00000125676 E037 0.5933762 0.0211644359 3.754936e-01 5.199212e-01 X 123622861 123623042 182 - 0.224 0.000 -10.720
ENSG00000125676 E038 200.3372594 0.0018805647 3.411894e-02 7.999370e-02 X 123623105 123623283 179 - 2.218 2.293 0.253
ENSG00000125676 E039 18.8360882 0.0026493316 9.171382e-02 1.778084e-01 X 123623284 123623512 229 - 1.186 1.337 0.530
ENSG00000125676 E040 12.5916724 0.0013554569 3.821178e-01 5.263581e-01 X 123623513 123623643 131 - 1.090 0.991 -0.365
ENSG00000125676 E041 26.0451116 0.0007327375 4.827706e-02 1.061199e-01 X 123623644 123623709 66 - 1.406 1.238 -0.587
ENSG00000125676 E042 11.0404710 0.0026859103 9.059474e-03 2.642601e-02 X 123623710 123623786 77 - 1.084 0.732 -1.344
ENSG00000125676 E043 207.1311234 0.0002436387 6.841956e-01 7.872144e-01 X 123623787 123623971 185 - 2.256 2.244 -0.041
ENSG00000125676 E044 176.0509128 0.0011745836 7.876976e-02 1.575420e-01 X 123624060 123624191 132 - 2.197 2.134 -0.212
ENSG00000125676 E045 152.0932383 0.0068389270 2.434319e-01 3.782102e-01 X 123624541 123624669 129 - 2.132 2.073 -0.199
ENSG00000125676 E046 167.7134497 0.0069108660 1.573702e-02 4.214194e-02 X 123625912 123626069 158 - 2.186 2.064 -0.411
ENSG00000125676 E047 161.4479340 0.0025531336 1.024718e-03 4.043698e-03 X 123626521 123626662 142 - 2.173 2.034 -0.465
ENSG00000125676 E048 207.4471500 0.0002307959 1.185884e-07 1.188500e-06 X 123627693 123627968 276 - 2.289 2.121 -0.560
ENSG00000125676 E049 145.9814521 0.0009971808 2.788493e-05 1.670636e-04 X 123631688 123631852 165 - 2.138 1.970 -0.563
ENSG00000125676 E050 156.4217830 0.0004761990 1.450340e-09 2.085327e-08 X 123632861 123633040 180 - 2.177 1.946 -0.775
ENSG00000125676 E051 134.8819640 0.0002639859 3.786465e-09 5.044191e-08 X 123633953 123634070 118 - 2.113 1.875 -0.799
ENSG00000125676 E052 128.3279394 0.0378759613 1.545597e-03 5.783077e-03 X 123636079 123636175 97 - 2.105 1.788 -1.065
ENSG00000125676 E053 105.2524122 0.0164323816 1.244918e-03 4.793173e-03 X 123638043 123638123 81 - 2.009 1.761 -0.835
ENSG00000125676 E054 113.2840658 0.0133825073 9.526010e-04 3.796915e-03 X 123638934 123639027 94 - 2.040 1.803 -0.800
ENSG00000125676 E055 3.7351761 0.0043773028 2.335789e-01 3.666544e-01 X 123640526 123640537 12 - 0.673 0.459 -0.982
ENSG00000125676 E056 105.5048483 0.0002672400 1.340290e-05 8.644008e-05 X 123640538 123640622 85 - 2.002 1.809 -0.651
ENSG00000125676 E057 103.3662897 0.0003753317 9.070697e-08 9.279708e-07 X 123644575 123644676 102 - 2.002 1.755 -0.833
ENSG00000125676 E058 91.6673583 0.0003850669 5.532672e-08 5.904395e-07 X 123644779 123644870 92 - 1.952 1.682 -0.911
ENSG00000125676 E059 80.9367488 0.0170125106 7.058633e-04 2.919859e-03 X 123644871 123644909 39 - 1.899 1.623 -0.932
ENSG00000125676 E060 91.4501566 0.0104673794 1.294996e-05 8.379611e-05 X 123645334 123645375 42 - 1.957 1.645 -1.052
ENSG00000125676 E061 163.6660800 0.0048997827 1.375496e-10 2.371961e-09 X 123665642 123665837 196 - 2.212 1.878 -1.120
ENSG00000125676 E062 146.8305803 0.0037280115 1.161454e-10 2.027964e-09 X 123667106 123667278 173 - 2.164 1.838 -1.095
ENSG00000125676 E063 137.7407325 0.0002207654 1.442410e-20 9.872119e-19 X 123668159 123668307 149 - 2.146 1.745 -1.349
ENSG00000125676 E064 63.4356581 0.0005251560 1.555706e-14 4.989401e-13 X 123668308 123668314 7 - 1.826 1.311 -1.764
ENSG00000125676 E065 108.1500877 0.0003042274 4.517031e-21 3.284983e-19 X 123671669 123671761 93 - 2.050 1.573 -1.613
ENSG00000125676 E066 110.1528972 0.0116928143 7.196117e-08 7.511614e-07 X 123686548 123686714 167 - 2.049 1.656 -1.322
ENSG00000125676 E067 94.1383693 0.0002850340 2.533200e-18 1.327911e-16 X 123696021 123696154 134 - 1.989 1.518 -1.594
ENSG00000125676 E068 107.6230172 0.0002971817 2.363077e-18 1.242514e-16 X 123696721 123696835 115 - 2.042 1.608 -1.467
ENSG00000125676 E069 53.2566152 0.0051428107 5.556412e-08 5.926725e-07 X 123696836 123696842 7 - 1.739 1.312 -1.465
ENSG00000125676 E070 66.9448275 0.0250087589 9.102060e-05 4.798814e-04 X 123697681 123697725 45 - 1.833 1.446 -1.317
ENSG00000125676 E071 60.4560760 0.0132939268 1.256523e-05 8.161995e-05 X 123697726 123697751 26 - 1.788 1.411 -1.285
ENSG00000125676 E072 60.8139096 0.0004031605 5.153528e-10 8.047482e-09 X 123703454 123703505 52 - 1.794 1.395 -1.363
ENSG00000125676 E073 0.1451727 0.0428376831 1.000000e+00   X 123706854 123706857 4 - 0.068 0.000 -8.720
ENSG00000125676 E074 74.5919416 0.0003293521 6.082459e-12 1.311373e-10 X 123706858 123706949 92 - 1.884 1.484 -1.357
ENSG00000125676 E075 64.7726531 0.0003964279 2.408295e-08 2.762773e-07 X 123712850 123712908 59 - 1.813 1.475 -1.149
ENSG00000125676 E076 50.7909503 0.0004224555 1.465466e-05 9.372048e-05 X 123732952 123733066 115 - 1.703 1.416 -0.980