ENSG00000125648

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000301454 ENSG00000125648 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC25A23 protein_coding protein_coding 70.75606 110.7126 45.11526 5.35508 0.2235984 -1.294943 43.600527 65.73710 29.470730 3.3629352 0.1426077 -1.157155 0.62542917 0.59363333 0.65323333 0.05960000 0.0016834176 0.0005002248 FALSE  
ENST00000595810 ENSG00000125648 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC25A23 protein_coding protein_coding 70.75606 110.7126 45.11526 5.35508 0.2235984 -1.294943 6.524167 13.24064 3.249654 0.7492623 0.2639560 -2.023272 0.08301250 0.11956667 0.07203333 -0.04753333 0.0005002248 0.0005002248 FALSE  
ENST00000598908 ENSG00000125648 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC25A23 protein_coding protein_coding 70.75606 110.7126 45.11526 5.35508 0.2235984 -1.294943 6.125299 10.22070 3.118148 0.7248355 0.1609996 -1.709524 0.08273333 0.09333333 0.06916667 -0.02416667 0.3305878446 0.0005002248 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000125648 E001 0.2924217 2.907852e-02 4.274622e-02   19 6436079 6436080 2 - 0.317 0.000 -11.527
ENSG00000125648 E002 27.1816000 8.205725e-04 5.693539e-01 6.959223e-01 19 6436081 6436117 37 - 1.353 1.391 0.133
ENSG00000125648 E003 29.2734341 1.103340e-03 3.537041e-01 4.979631e-01 19 6436118 6436120 3 - 1.363 1.428 0.223
ENSG00000125648 E004 32.4474148 7.688473e-04 1.262633e-01 2.289563e-01 19 6436121 6436130 10 - 1.373 1.479 0.365
ENSG00000125648 E005 67.5013487 3.873774e-04 8.463357e-02 1.668114e-01 19 6436131 6436173 43 - 1.699 1.781 0.279
ENSG00000125648 E006 80.7216802 1.607652e-03 4.907656e-02 1.075130e-01 19 6436174 6436191 18 - 1.768 1.862 0.317
ENSG00000125648 E007 95.5179998 8.158579e-04 8.581437e-03 2.524147e-02 19 6436192 6436217 26 - 1.824 1.937 0.381
ENSG00000125648 E008 258.3993622 1.730594e-04 4.258133e-15 1.479895e-13 19 6436218 6436420 203 - 2.164 2.379 0.720
ENSG00000125648 E009 135.1076534 2.495782e-04 2.157296e-12 5.010339e-11 19 6436421 6436464 44 - 1.834 2.108 0.920
ENSG00000125648 E010 24.9227527 1.777801e-03 6.875503e-02 1.413043e-01 19 6436465 6436468 4 - 1.220 1.370 0.524
ENSG00000125648 E011 6.8470954 2.484565e-03 3.085114e-01 4.508043e-01 19 6438191 6438312 122 - 0.725 0.863 0.548
ENSG00000125648 E012 89.2914254 5.517342e-04 1.521149e-07 1.491671e-06 19 6438447 6438534 88 - 1.675 1.926 0.847
ENSG00000125648 E013 12.7399203 2.817088e-02 2.189601e-01 3.491469e-01 19 6438724 6438771 48 - 0.931 1.097 0.613
ENSG00000125648 E014 10.5696368 2.986009e-02 5.864696e-01 7.100330e-01 19 6438772 6438821 50 - 0.931 1.006 0.279
ENSG00000125648 E015 1.2553459 3.746712e-02 9.140769e-01 9.495743e-01 19 6440064 6440064 1 - 0.317 0.337 0.122
ENSG00000125648 E016 1.6960608 5.095370e-02 5.060664e-01 6.417530e-01 19 6440065 6440066 2 - 0.499 0.373 -0.662
ENSG00000125648 E017 34.7267462 5.340620e-03 1.973733e-01 3.229388e-01 19 6440067 6440099 33 - 1.411 1.507 0.331
ENSG00000125648 E018 73.7929152 3.027357e-03 6.565748e-04 2.739843e-03 19 6440100 6440122 23 - 1.649 1.841 0.648
ENSG00000125648 E019 128.2970874 1.886718e-03 4.359735e-08 4.758808e-07 19 6440123 6440184 62 - 1.841 2.084 0.816
ENSG00000125648 E020 422.3732185 2.399907e-03 6.818228e-09 8.671407e-08 19 6440185 6440322 138 - 2.407 2.589 0.606
ENSG00000125648 E021 403.1320212 3.023289e-03 7.538380e-06 5.149917e-05 19 6440323 6440378 56 - 2.413 2.563 0.501
ENSG00000125648 E022 1342.0200516 1.751255e-03 1.736440e-02 4.574335e-02 19 6440379 6441123 745 - 3.017 3.065 0.160
ENSG00000125648 E023 450.6955419 3.601014e-04 4.595705e-01 5.996781e-01 19 6441124 6441180 57 - 2.572 2.582 0.035
ENSG00000125648 E024 682.8472758 1.942042e-03 2.193463e-01 3.495844e-01 19 6441181 6441341 161 - 2.740 2.768 0.094
ENSG00000125648 E025 463.1417181 3.088932e-03 8.028428e-01 8.744474e-01 19 6441342 6441437 96 - 2.590 2.595 0.017
ENSG00000125648 E026 356.6924326 2.195643e-03 4.824515e-01 6.205804e-01 19 6441438 6441473 36 - 2.500 2.475 -0.084
ENSG00000125648 E027 276.3030574 1.457828e-03 2.951508e-02 7.099921e-02 19 6441474 6441484 11 - 2.422 2.353 -0.230
ENSG00000125648 E028 942.4132543 9.780354e-05 3.388516e-12 7.625851e-11 19 6441485 6441929 445 - 2.971 2.876 -0.318
ENSG00000125648 E029 243.1225840 2.764688e-04 1.014910e-09 1.503885e-08 19 6441930 6441978 49 - 2.428 2.267 -0.539
ENSG00000125648 E030 511.7410278 1.413705e-04 2.281317e-08 2.631606e-07 19 6441979 6442159 181 - 2.711 2.607 -0.348
ENSG00000125648 E031 9.7925101 2.022882e-03 8.620423e-01 9.150734e-01 19 6443562 6443656 95 - 0.983 0.958 -0.094
ENSG00000125648 E032 630.4132205 3.005087e-04 3.916931e-01 5.356260e-01 19 6444151 6444301 151 - 2.715 2.726 0.034
ENSG00000125648 E033 500.6763856 5.505891e-04 5.806043e-01 7.053051e-01 19 6452312 6452479 168 - 2.619 2.626 0.022
ENSG00000125648 E034 3.6807792 1.065044e-01 1.136491e-01 2.108433e-01 19 6452480 6452601 122 - 0.805 0.510 -1.266
ENSG00000125648 E035 408.6849964 9.046508e-04 8.328607e-01 8.952886e-01 19 6453981 6454088 108 - 2.536 2.536 0.002
ENSG00000125648 E036 589.6197705 7.759670e-04 5.304780e-01 6.630870e-01 19 6454323 6454475 153 - 2.709 2.691 -0.058
ENSG00000125648 E037 661.3409518 2.723781e-03 9.321578e-02 1.801470e-01 19 6454559 6454717 159 - 2.785 2.734 -0.168
ENSG00000125648 E038 23.7367709 1.360282e-03 5.898589e-01 7.128541e-01 19 6455952 6456092 141 - 1.363 1.315 -0.167
ENSG00000125648 E039 2.0260584 6.911365e-02 7.411807e-01 8.304475e-01 19 6456303 6456419 117 - 0.499 0.438 -0.308
ENSG00000125648 E040 583.8416217 4.196611e-03 2.345615e-02 5.869522e-02 19 6456420 6456531 112 - 2.753 2.673 -0.268
ENSG00000125648 E041 445.0622771 6.828734e-03 6.557126e-02 1.359999e-01 19 6457503 6457590 88 - 2.635 2.555 -0.268
ENSG00000125648 E042 407.8968219 5.236119e-03 3.008889e-02 7.213131e-02 19 6458198 6458324 127 - 2.602 2.515 -0.290
ENSG00000125648 E043 305.6572645 1.154730e-02 6.062578e-03 1.877492e-02 19 6459473 6459844 372 - 2.523 2.372 -0.503
ENSG00000125648 E044 0.0000000       19 6460745 6460851 107 -      
ENSG00000125648 E045 0.0000000       19 6465081 6465203 123 -