ENSG00000125505

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000245615 ENSG00000125505 HEK293_OSMI2_2hA HEK293_TMG_2hB MBOAT7 protein_coding protein_coding 50.33393 69.4459 37.46028 5.843546 1.128861 -0.8903506 22.659457 36.754653 14.612381 2.9619134 0.6263166 -1.3301411 0.43217083 0.52956667 0.3908667 -0.138700000 0.0002568188 0.0002568188 FALSE TRUE
ENST00000391754 ENSG00000125505 HEK293_OSMI2_2hA HEK293_TMG_2hB MBOAT7 protein_coding protein_coding 50.33393 69.4459 37.46028 5.843546 1.128861 -0.8903506 2.574923 3.253376 1.849404 0.1916741 0.1861244 -0.8115252 0.05141250 0.04706667 0.0492000 0.002133333 0.9215428102 0.0002568188 FALSE TRUE
ENST00000414665 ENSG00000125505 HEK293_OSMI2_2hA HEK293_TMG_2hB MBOAT7 protein_coding protein_coding 50.33393 69.4459 37.46028 5.843546 1.128861 -0.8903506 3.467982 1.245732 4.072093 1.1013361 1.1775283 1.7007806 0.07687500 0.01656667 0.1106333 0.094066667 0.1459242855 0.0002568188 FALSE FALSE
ENST00000464098 ENSG00000125505 HEK293_OSMI2_2hA HEK293_TMG_2hB MBOAT7 protein_coding retained_intron 50.33393 69.4459 37.46028 5.843546 1.128861 -0.8903506 2.244369 0.000000 1.464939 0.0000000 1.4649391 7.2045116 0.05457917 0.00000000 0.0370000 0.037000000 0.7776532197 0.0002568188 FALSE FALSE
ENST00000494142 ENSG00000125505 HEK293_OSMI2_2hA HEK293_TMG_2hB MBOAT7 protein_coding retained_intron 50.33393 69.4459 37.46028 5.843546 1.128861 -0.8903506 15.270035 21.851021 12.123240 1.3301719 0.4585647 -0.8493960 0.30478333 0.31600000 0.3236000 0.007600000 0.8994880074 0.0002568188 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000125505 E001 1.067386 0.0164215350 8.621431e-01 9.151189e-01 19 54173412 54173412 1 - 0.294 0.273 -0.145
ENSG00000125505 E002 2.454287 0.0076923603 9.090030e-01 9.461883e-01 19 54173413 54173414 2 - 0.468 0.504 0.177
ENSG00000125505 E003 5.440236 0.0032033606 3.094826e-01 4.517861e-01 19 54173415 54173418 4 - 0.642 0.811 0.689
ENSG00000125505 E004 1286.762672 0.0049201202 5.207380e-06 3.690556e-05 19 54173419 54174073 655 - 2.932 3.098 0.552
ENSG00000125505 E005 833.943586 0.0019422686 2.091715e-05 1.291662e-04 19 54174074 54174431 358 - 2.774 2.901 0.423
ENSG00000125505 E006 58.851484 0.0068110136 2.332364e-01 3.662651e-01 19 54178337 54178764 428 - 1.649 1.751 0.346
ENSG00000125505 E007 469.725236 0.0001325447 4.633347e-02 1.026396e-01 19 54178765 54178941 177 - 2.572 2.632 0.201
ENSG00000125505 E008 453.001231 0.0001412207 7.244104e-08 7.557540e-07 19 54178942 54179662 721 - 2.654 2.581 -0.243
ENSG00000125505 E009 457.694494 0.0010476024 4.608613e-09 6.049666e-08 19 54179663 54180772 1110 - 2.681 2.576 -0.349
ENSG00000125505 E010 168.603367 0.0036491594 7.962087e-01 8.699025e-01 19 54180773 54180858 86 - 2.143 2.183 0.135
ENSG00000125505 E011 385.540687 0.0081863892 8.209890e-01 8.871632e-01 19 54180859 54181115 257 - 2.500 2.546 0.156
ENSG00000125505 E012 162.035079 0.0021140273 3.188751e-01 4.618744e-01 19 54181116 54181123 8 - 2.162 2.152 -0.034
ENSG00000125505 E013 165.012288 0.0021032254 9.383806e-02 1.811242e-01 19 54181124 54181133 10 - 2.188 2.153 -0.116
ENSG00000125505 E014 386.713975 0.0001422164 3.876370e-01 5.317759e-01 19 54183521 54183680 160 - 2.528 2.534 0.021
ENSG00000125505 E015 4.522744 0.1099005293 6.334884e-01 7.481888e-01 19 54186956 54187160 205 - 0.768 0.672 -0.393
ENSG00000125505 E016 380.514474 0.0001813927 6.156972e-02 1.292747e-01 19 54187161 54187285 125 - 2.535 2.521 -0.046
ENSG00000125505 E017 180.508519 0.0001969997 6.167616e-02 1.294455e-01 19 54187286 54187287 2 - 2.224 2.194 -0.102
ENSG00000125505 E018 1.393142 0.0108202917 3.365639e-02 7.907265e-02 19 54187288 54187309 22 - 0.000 0.439 10.900
ENSG00000125505 E019 351.834115 0.0015588813 1.242384e-02 3.455521e-02 19 54188217 54188346 130 - 2.525 2.483 -0.138
ENSG00000125505 E020 1.243894 0.0240887329 4.839330e-01 6.219533e-01 19 54188347 54188412 66 - 0.390 0.274 -0.726
ENSG00000125505 E021 190.449366 0.0062499426 4.653759e-03 1.496843e-02 19 54188433 54188511 79 - 2.301 2.199 -0.339
ENSG00000125505 E022 1.883237 0.1338885398 9.744149e-01 9.880293e-01 19 54189191 54189301 111 - 0.390 0.412 0.122
ENSG00000125505 E023 2.310147 0.2936886702 8.904486e-01 9.340223e-01 19 54189302 54189337 36 - 0.468 0.482 0.073
ENSG00000125505 E024 214.967915 0.0146421883 1.618402e-05 1.025149e-04 19 54189338 54189882 545 - 2.438 2.206 -0.774